The First Crystal Structure of an Anti-Geometric Homoleptic Zinc Complex from an Unsymmetric Curcuminoid Ligand DOI Creative Commons
Marco A. Obregón‐Mendoza,

Gabriela Marmolejo Escamilla,

Rosario Tavera-Hernández

et al.

Crystals, Journal Year: 2024, Volume and Issue: 14(9), P. 751 - 751

Published: Aug. 24, 2024

Curcuminoids are widely studied due to their well-recognized therapeutic properties. These molecules often derivatized with metals, producing corresponding homoleptic metal complexes. Numerous crystal structures of symmetric curcuminoids physiologically essential metals known, although the literature lacks reports complexes unsymmetric (or hemi-curcuminoids) as ligands. Three unknowns must be solved when an curcuminoid ligand is reacted a ion: (a) degree coordination (MLn); (b) spatial geometry; and (c) conformational nature (syn or anti) complex. Herein, we report structure anti-isomer Zn complex hemi-curcuminoid 5-hydroxy-1-(4-methoxyphenyl)hexa-1,4-dien-3-one. While NMR shows only one set signals for this complex, unambiguous stereochemistry was established through single-crystal X-ray diffractometry, revealing anti-hexacoordinated octahedral ML2 structure.

Language: Английский

Enemies or Allies? Hormetic and Apparent Non-Dose-Dependent Effects of Natural Bioactive Antioxidants in the Treatment of Inflammation DOI Open Access
Uxía Barreiro-Sisto, Sandra Fernández‐Fariña, Ana María González Noya

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1892 - 1892

Published: Feb. 4, 2024

This review aims to analyze the emerging number of studies on biological media that describe unexpected effects different natural bioactive antioxidants. Hormetic effects, with a biphasic response depending dose, or activities are apparently non-dose-dependent, have been described for compounds such as resveratrol, curcumin, ferulic acid linoleic acid, among others. The analysis reported confirms incidence these types which should be taken into account by researchers, discarding initial interpretations imprecise methodologies measurements. enhance research mechanisms action, particularly those studied in field basic research, will help us understand causes unusual behaviors, inactivation signaling pathways immune defense system. Antioxidative and anti-inflammatory addressed ways go beyond mere statistical approach. In this work, some may explain understanding revised, paying special attention ability selected (curcumin, acid) form metal complexes activity media.

Language: Английский

Citations

6
The Homoleptic Curcumin-Copper Single Crystal (ML2): A Long Awaited Cherry on the Cake in the Field of Curcumin Metal Complexes DOI Open Access

Antonino Arenaza Corona,

Marco A. Obregón‐Mendoza,

William Meza Morales

et al.

Published: June 29, 2023

The first single crystal structure of the homoleptic copper (II) ML2 complex (M=Cu (II), L=curcumin) was obtained and its elucidated by X-ray diffraction showing a square planar geometry. supramolecular arrangement is supported C-H···O interactions solvent (MeOH) plays an important role in stabilizing packing. cytotoxic activity against six cancer cell lines substantially surpasses that curcumin itself, it particularly selective leukemia (K562) human glioblastoma (U251) with similar antioxidant to BHT. This constitutes pristine complexed metal ion.

Language: Английский

Citations

4
First Gallium and Indium Crystal Structures of Curcuminoid Homoleptic Complexes: All-Different Ligand Stereochemistry and Cytotoxic Potential DOI Open Access
William Meza-Morales, Yair Alvarez-Ricardo, Leidys L. Pérez-González

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16324 - 16324

Published: Nov. 15, 2023

The crystal structure determination of metal complexes curcuminoids is a relevant topic to assess their unequivocal molecular structure. We report herein the first two X-ray structures homoleptic curcuminoid, namely Dimethoxycurcumin (DiMeOC), with gallium and indium. Such successful achievement can be attributed suppression interactions from phenolic groups, which favor an appropriate setup, rendering ((DiMeOC)2-Ga) indium ((DiMeOC)3-In) crystals. Surprisingly, conformation ligands in shows differences each complex. Thus, (DiMeOC)2-Ga complex show different conformers molecules asymmetric unit. However, (DiMeOC)3-In exhibit three conformations within same molecule unit, constituting such case described for ML3 cytotoxic activity 4-fold higher than cisplatin against K562 cell line has comparable towards U251 PC-3 lines. Interestingly, this times lesser toxicity even slightly cytotoxicity curcumin itself.

Language: Английский

Citations

2
The First Crystal Structure of an Anti-Geometric Homoleptic Zinc Complex from an Unsymmetric Curcuminoid Ligand DOI Creative Commons
Marco A. Obregón‐Mendoza,

Gabriela Marmolejo Escamilla,

Rosario Tavera-Hernández

et al.

Crystals, Journal Year: 2024, Volume and Issue: 14(9), P. 751 - 751

Published: Aug. 24, 2024

Curcuminoids are widely studied due to their well-recognized therapeutic properties. These molecules often derivatized with metals, producing corresponding homoleptic metal complexes. Numerous crystal structures of symmetric curcuminoids physiologically essential metals known, although the literature lacks reports complexes unsymmetric (or hemi-curcuminoids) as ligands. Three unknowns must be solved when an curcuminoid ligand is reacted a ion: (a) degree coordination (MLn); (b) spatial geometry; and (c) conformational nature (syn or anti) complex. Herein, we report structure anti-isomer Zn complex hemi-curcuminoid 5-hydroxy-1-(4-methoxyphenyl)hexa-1,4-dien-3-one. While NMR shows only one set signals for this complex, unambiguous stereochemistry was established through single-crystal X-ray diffractometry, revealing anti-hexacoordinated octahedral ML2 structure.

Language: Английский

Citations

0