Prevention of Pregnancy Complications Using a Multimodal Lifestyle, Screening, and Medical Model

Published: June 19, 2024

Understanding and preventing the “great obstetrical syndromes” has been focus of pregnancy research for decades. The combined global impact from these syndromes on maternal perinatal morbidity mortality is compounded by increased long-term risk adverse health effects following pregnancy. Accumulating evidence indicates that conditions such as pre-eclampsia, fetal growth restriction, spontaneous preterm labour, stillbirth, are with etiologic heterogeneity share common pathophysiologic pathways involving placental dysfunction. Recently, importance interaction between genomes extended to include epigenetic pre-existing pathophysiology development highlights nutritional environmental factors in altered placentation. Validated first-trimester screening algorithms preeclampsia can identify high-risk women prophylactic treatment low-dose aspirin be initiated. High-risk monitored during second trimester using clinical assessment, ultrasound, biochemical markers, able predict complications prior signs symptoms. integration lifestyle interventions, screening, medical management represents a conceptual advance care. This approach potential significantly reduce complications, mortality, outcomes later life, health-care costs.

Language: Английский

Reducing the Risk of Pre-eclampsia in Women with Polycystic Ovary Syndrome using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies

Published: Dec. 27, 2023

Polycystic ovary syndrome (PCOS) is a multisystem disorder that presents with variety of phenotypes involving metabolic, endocrine, reproductive, and psychological symptoms signs. Women PCOS are at increased risk pregnancy complications including implantation failure, miscarriage, gestational diabetes, fetal growth restriction, preterm labour, preeclampsia (PE). This may be attributed to the presence specific susceptibility features associated before during pregnancy, such as chronic systemic inflammation, insulin resistance (IR), hyperandrogenism, all which have been an complications. Many reversible following lifestyle interventions diet exercise, pregnant women healthy found lower complications, PE. review summarizes evidence investigating PE role nutritional factors in PCOS. The findings suggest beneficial aspects management PCOS, recommended evidenced-based international guidelines, extend improved outcomes. Identifying high-risk will allow targeted interventions, early screening, surveillance for should included assessment algorithms

Language: Английский