Synergistic Effects of Omega-3 Fatty Acids and Physical Activity on Oxidative Stress Markers and Antioxidant Mechanisms in Aged Rats DOI Open Access
Zuzana Paduchová, Lívia Gajdošová, Barbora Katrenčíková

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 96 - 96

Published: Dec. 29, 2024

Background: Aging induces degenerative processes in the body, contributing to onset of various age-associated diseases that affect population. Inadequate dietary habits and low physical activity are major contributors increased morbidity during aging. This study aimed investigate combined effects omega-3 fatty acid supplementation on markers oxidative stress antioxidant defense mechanisms aged male Wistar rats (23–24 months). Methods: The were randomly divided into four experimental groups: a sedentary control (placebo, no exercise), trained (placebo moderate-intensity graded aerobic exercise; Ex), two groups supplemented with (160 mg/kg body weight; O1 + Ex) high (320 O2 doses acids. biochemical functional parameters related sarcopenia measured blood gastrocnemius muscle. Results: results demonstrated dose-dependent, synergistic activity. higher dose weight) improved plasma capacity (TEAC, +21.01%, p < 0.01) GPx (+78.05%, 0.05) while reducing CAT erythrocytes (−19.92%, 0.05), likely as an adaptive response. Combined interventions also normalized cholesterol levels, (stride length, +14.82%, 0.001), enhanced protection rats. Conclusions: These findings highlight potential combining counteract aging-related changes. Further research is needed elucidate underlying evaluate long-term benefits these strategies aging populations.

Language: Английский

Impact of Physical Activity on Cellular Metabolism Across Both Neurodegenerative and General Neurological Conditions: A Narrative Review DOI Creative Commons
Vicente Javier Clemente‐Suárez, Alejandro Rubio-Zarapuz, Pedro Belinchón-deMiguel

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 1940 - 1940

Published: Nov. 22, 2024

Background: Regular physical activity plays a crucial role in modulating cellular metabolism and mitigating the progression of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Multiple Sclerosis. Objective: The objective this review is to evaluate molecular mechanisms by which exercise influences metabolism, with focus on its potential therapeutic intervention for neurological disorders. Methods: A comprehensive literature was conducted using peer-reviewed scientific articles, period between 2015 2024, analyze effects mitochondrial function, oxidative stress, metabolic health. Results: findings indicate that promotes biogenesis, enhances phosphorylation, reduces reactive oxygen species, contributing improved energy production resilience. These adaptations are associated delayed disease reduced symptoms patients conditions. Additionally, integrating nutritional strategies may further enhance outcomes addressing disturbances comprehensively. Conclusions: This concludes personalized protocols should be developed optimize benefits diseases, while future research biomarker development individualized treatment approaches. highlight importance non-pharmacological interventions managing diseases.

Language: Английский

Citations

2
Hydrogen-Rich Water to Enhance Exercise Performance: A Review of Effects and Mechanisms DOI Creative Commons

Qiaorui Zhou,

Huixin Li, Ye Zhang

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(10), P. 537 - 537

Published: Oct. 7, 2024

: Hydrogen-rich water (HRW) has garnered significant interest within the sports and exercise science community due to its selective antioxidant properties. Despite potential benefits, comprehensive reviews specifically addressing effects on athletic performance are limited. This review aims assess impact of HRW explore underlying molecular biological mechanisms, with goal elucidating how might enhance performance.

Language: Английский

Citations

1
8-Week Kaempferia parviflora Extract Administration Improves Submaximal Exercise Capacity in Mice by Enhancing Skeletal Muscle Antioxidant Gene Expression and Plasma Antioxidant Capacity DOI Creative Commons
Jiapeng Huang, Yishan Tong, Shuo Wang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1147 - 1147

Published: Sept. 23, 2024

Black ginger (Kaempferia parviflora) extract (KPE) is extracted from a family plant grown in Thailand. The polyphenolic components have potential antioxidant effects and been reported to enhance exercise performance. However, the impact of long-term KPE administration combined with training on endurance performance healthy individuals has not fully studied. In this study, mouse model was used investigate 8 weeks voluntary wheel running submaximal capacity its mechanism. results showed that significantly enhanced mice extended daily distance. By measuring oxidative stress markers plasma mRNA expression genes skeletal muscle, we found increased levels activated Nrf2 (Nuclear factor erythroid 2-related 2)/ARE (Antioxidant Response Element) pathway downstream muscle. These suggest may muscle by activating Nrf2-ARE-centered pathway, thereby increasing distance improving mice.

Language: Английский

Citations

0
Oxidative DNA Damage and Arterial Hypertension in Light of Current ESC Guidelines DOI Open Access

Radka Hazuková,

Z Zadák,

M Pleskot

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12557 - 12557

Published: Nov. 22, 2024

A new insight into oxidative stress is based on deoxyribonucleic acid (DNA) damage. DNA the pivotal biopolymer for life and health. Arterial hypertension (HT) a globally common disease major risk factor numerous cardiovascular (CV) conditions non-cardiac complications, making it significant health socio-economic problem. The aetiology of HT multifactorial. Oxidative main driver. damage (oxidised guanosine (8OHdG), strand breaks (SSBs, DSBs)) seems to be crucial initiating causal molecular mechanism leading HT, acting through resulting consequences (inflammation, fibrosis, vascular remodelling, stiffness, thickness, endothelial dysfunction). In light current European Society Cardiology (ESC) guidelines with defined gaps in evidence, this manuscript, first time, (1) summarizes evidence other CV factors, (2) incorporates them context known mechanisms genesis, (3) proposes existing concept genesis innovatively supplemented damage, (4) mentions such as promising targets treatment (DNA response (DDR) pathways).

Language: Английский

Citations

0
Increased activity of the catalase enzyme after physical exercise as a signal for reducing hydrogen peroxide (H2O2): a systematic review DOI Open Access

Junian Cahyanto Wibawa,

Angga Setiawan, Diyanti Jati Pratiwi

et al.

Published: Dec. 31, 2024

Oxidative stress is a process of oxidation reactions in the body, one which triggered by physical exercise. Physical exercise triggers an increase ROS (reactive oxygen species), also has impact on increasing endogenous antioxidants body such as enzyme catalase. The aim this research to determine how activity impacts catalase and role counteracting free radicals caused oxidative during exercise, its reducing H2O2 (hydrogen peroxide). For study, number journal databases were searched, including Embase, PubMed, Web Science, Science Direct, Scopus. study took into account factors, studies antioxidants, published previous five years. Only articles non-reputable journals not indexed specified inclusion criteria excluded from our study. A total 1,560 papers located using Scopus databases. About ten carefully selected peer-reviewed addressed need for systemic change. Systematic Preferred Reporting Items Reviews Meta-Analysis (PRISMA) items used creation standard operating procedures investigation. findings analysis showed that sports been shown antioxidants. Catalase antioxidant functions reduce production H2O so it reactive. Regular strongly recommended counteract improving overall health. limitations review only discuss effect (CAT) plays next review, effects genes related signal transmission affects them can be studied depth.

Language: Английский

Citations

0
Synergistic Effects of Omega-3 Fatty Acids and Physical Activity on Oxidative Stress Markers and Antioxidant Mechanisms in Aged Rats DOI Open Access
Zuzana Paduchová, Lívia Gajdošová, Barbora Katrenčíková

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 96 - 96

Published: Dec. 29, 2024

Background: Aging induces degenerative processes in the body, contributing to onset of various age-associated diseases that affect population. Inadequate dietary habits and low physical activity are major contributors increased morbidity during aging. This study aimed investigate combined effects omega-3 fatty acid supplementation on markers oxidative stress antioxidant defense mechanisms aged male Wistar rats (23–24 months). Methods: The were randomly divided into four experimental groups: a sedentary control (placebo, no exercise), trained (placebo moderate-intensity graded aerobic exercise; Ex), two groups supplemented with (160 mg/kg body weight; O1 + Ex) high (320 O2 doses acids. biochemical functional parameters related sarcopenia measured blood gastrocnemius muscle. Results: results demonstrated dose-dependent, synergistic activity. higher dose weight) improved plasma capacity (TEAC, +21.01%, p < 0.01) GPx (+78.05%, 0.05) while reducing CAT erythrocytes (−19.92%, 0.05), likely as an adaptive response. Combined interventions also normalized cholesterol levels, (stride length, +14.82%, 0.001), enhanced protection rats. Conclusions: These findings highlight potential combining counteract aging-related changes. Further research is needed elucidate underlying evaluate long-term benefits these strategies aging populations.

Language: Английский

Citations

0