The Role of Nutrition, Oxidative Stress, and Trace Elements in the Pathophysiology of Autism Spectrum Disorders

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 808 - 808

Published: Jan. 18, 2025

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication and interaction, alongside repetitive behaviors, atypical sensory-motor patterns. The growing prevalence of ASD has driven substantial advancements research aimed at understanding its etiology, preventing onset, mitigating impact. This ongoing effort necessitates continuous updates to the body knowledge identification previously unexplored factors. present study addresses this need examining roles nutrition, oxidative stress, trace elements pathophysiology ASD. In review, an overview provided key dietary recommendations for individuals with ASD, including gluten-free casein-free (GFCF) diets, ketogenic diets (KDs), other nutritional interventions. Furthermore, it explores involvement stress highlights significance maintaining neuropsychiatric health. impact these factors on molecular cellular mechanisms was discussed, therapeutic strategies their efficacy managing

Language: Английский

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The “Burden” of Childhood Obesity on Bone Health: A Look at Prevention and Treatment

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 491 - 491

Published: Jan. 29, 2025

Childhood obesity represents a multifaceted challenge to bone health, influenced by combination of endocrine, metabolic, and mechanical factors. Excess body fat correlates with an increase in mineral density (BMD) yet paradoxically elevates fracture risk due compromised quality increased loading on atypical sites. Additionally, subjects syndromic obesity, as well individuals nutritional patterns, including those eating disorders, show fragility through unique genetic hormonal dysregulations. Emerging evidence underscores the adverse effects new pharmacological treatments for severe health. Novel drugs, such glucagon-like peptide-1 (GLP-1) receptor agonists, bariatric surgery demonstrate potential achieving weight loss, though limited is available regarding their short- long-term impacts skeletal This review provides comprehensive analysis mechanisms underlying impact childhood It critically appraises from vitro studies, animal models, clinical research children exogenous disorders. also explores emerging surgical integrity, highlights prevention strategies, identifies gaps.

Language: Английский

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Impact of Gluten-Free and Casein-Free diet on the quality of life of Autistic children and Adolescents: A Scoping review

Published: May 30, 2024

Background: Gluten and casein-containing foods could aggravate the symptoms of children adolescents with autism spectrum disorder (ASD), subsequently impact their quality life. However, there is a mixed opinion among researchers concerning alternative diet on reducing ASD symptoms. Objective: This scoping review aimed at examining ‘’gluten-free, casein-free’’ (GFCF) health outcomes life autistic adolescents. Methods: A literature was performed following Joanna Briggs Institute (JBI) guidelines. Four databases including EbscoHost, Medline, CINAHL ProQuest were used to obtain subject-specific studies relevant research question published between July 2013 March 2024. comprehensive search using keywords such as “autism disorder”, “gluten-free diet”, “casein-free diet” conducted articles related focus area. Only full-text, peer-reviewed, written in English selected. Data extraction data analysis according Preferred Reporting Items for Systematic Reviews Meta-Analyses- extension Scoping Review (PRISMA-ScR) protocol. Results: From initial 586 total 27 included final review. The thematic ‘GFCF improvement core symptoms’’, “the gut-brain link’’, ‘’dietary interventions autism’’, ‘’possible side effects due GCFC diet’’, ‘’ inconclusive opinions’’. Majority showed positive effect GFCF variety changes cognitive skills, behaviour, gastrointestinal while some conflicting evidence. Conclusion: currently available evidence ‘GFCF’’ may warrant potentially effective alleviating disorders. this highlighted need more provide reliable sufferers guide practice.

Language: Английский

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Shared Immune and Nutrient Metabolism Pathways Between Autism Spectrum Disorder and Celiac Disease: An In Silico Approach

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1439 - 1439

Published: April 25, 2025

Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication difficulties and repetitive behaviors. Emerging evidence suggests potential link between ASD celiac disease (CD), possibly mediated immune dysregulation nutrient deficiencies. This study explores the shared biological pathways CD using an in silico approach. Methods: Gene–disease associations for were retrieved from DisGeNET MedGen Concept IDs (C1510586 C0007570, respectively). An over-representation analysis (ORA) was conducted GeneTrail 3.2 to identify significantly enriched pathways, which then compared overlap. A false discovery rate (FDR) < 0.05 considered statistically significant. Results: The gene–disease association identified 536 ASD-related genes 52 CD-related genes. ORA revealed several including cellular metabolism, micronutrient processing (e.g., folate, selenium, vitamin A). These findings suggest dysfunction malabsorption as mechanistic links CD. Conclusions: observed pathway overlap supports hypothesis that metabolic disturbances contribute both Nutrient deficiencies, driven CD-associated malabsorption, may exacerbate symptoms. Additionally, sensory abnormalities could impact dietary choices, complicating gluten-free diet adherence. Future studies should validate these clinical cohorts explore interventions, such targeted supplementation, mitigate symptoms individuals with

Language: Английский

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Microbiota and Autism: A Review on Oral and Gut Microbiome Analysis Through 16S rRNA Sequencing

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2686 - 2686

Published: Nov. 25, 2024

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with multifactorial etiologies, including genetic, environmental, and microbiological factors. In recent years, increasing attention has been given to the role of gut microbiota in ASD. Emerging evidence suggests that dysbiosis may influence central nervous system through gut-brain axis, potentially impacting behavior neurodevelopment. The use 16S rRNA gene sequencing become pivotal tool profiling microbial communities associated ASD, offering valuable insights into bacterial diversity, composition, potential functional roles. This review aims provide comprehensive analysis current findings on relationship between oral particular focus studies utilizing sequencing. We will explore how microbiome alterations contribute ASD pathophysiology, discuss limitations existing research, propose future directions for integration diagnostics treatment strategies. These underscore modulating symptoms. data suggest specific taxa are consistently altered which have implications understanding axis its

Language: Английский

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