Canalization and plasticity in psychopathology

Neuropharmacology, Journal Year: 2022, Volume and Issue: 226, P. 109398 - 109398

Published: Dec. 27, 2022

This theoretical article revives a classical bridging construct, canalization, to describe new model of general factor psychopathology. To achieve this, we have distinguished between two types plasticity, an early one that call 'TEMP' for 'Temperature or Entropy Mediated Plasticity', and another, 'canalization', which is close Hebbian plasticity. These forms plasticity can be most easily by their relationship 'precision' inverse variance; TEMP relates increased variance decreased precision, whereas the opposite true canalization. also subsumes learning rate, (Ising) temperature entropy. Dictionary definitions 'plasticity' it as property being shaped molded; better match this. Importantly, propose 'pathological' phenotypes develop via mechanisms canalization defensive response adversity associated distress dysphoria. Our states entrenches in psychopathology, narrowing phenotypic state-space agent develops expertise pathology. We suggest - combined with gently guiding psychological support counter address questions whether when adaptive versus maladaptive, furnish our references basic human neuroscience, offer concrete experiments measures test its main hypotheses implications. part Special Issue on "National Institutes Health Psilocybin Research Speaker Series".

Language: Английский

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Multi-strain Probiotic Formulation Reverses Maternal Separation and Chronic Unpredictable Mild Stress-Generated Anxiety- and Depression-like Phenotypes by Modulating Gut Microbiome–Brain Activity in Rats

ACS Chemical Neuroscience, Journal Year: 2022, Volume and Issue: 13(13), P. 1948 - 1965

Published: June 23, 2022

Depression is a debilitating mental disorder that affects >322 million people worldwide. Despite the availability of several antidepressant agents, many patients remain treatment refractory. A growing literature study has indicated role gut microbiota in neuropsychiatric disorders. Herein, we examined psychobiotic-like activity multi-strain probiotic formulation maternal separation (MS) and chronic unpredictable mild stress (CUMS) models anxiety- depression-like phenotypes Sprague-Dawley rats. Early- late-life was employed both male female rats by exposing them to MS CUMS. The (Cognisol) containing Bacillus coagulans Unique IS-2, Lactobacillus plantarum UBLP-40, rhamnosus UBLR-58, Bifidobacterium lactis UBBLa-70, breve UBBr-01, infantis UBBI-01 at total strength 10 billion cfu along with l-glutamine administered for 6 weeks via drinking water. Neurobehavioral assessment done using forced swim test (FST), sucrose preference (SPT), elevated plus maze (EPM), open field (OFT). Animals were sacrificed after behavioral assessment, blood, brain, intestine samples collected analyze levels cytokines, metabolites, neurotransmitters histology. exposed showed increased passivity, consumed less solution, minimally explored arms FST, SPT, EPM, respectively. Administration probiotics ameliorated abnormalities. locomotor animals OFT their body weight remained unchanged across groups. Cognisol reversed decreased BDNF serotonin CRP, TNF-α, dopamine hippocampus and/or frontal cortex. also restored plasma l-tryptophan, l-kynurenine, kynurenic-acid, 3-hydroxyanthranilic acid; Firmicutes-to-Bacteroides ratio; acetate, propionate, butyrate fecal samples; villi/crypt goblet cell count, which manifested restoration intestinal functions. We suggest glutamine + UCMS-generated reshaping microbiome–brain sexes.

Language: Английский

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Revealing the importance of prenatal gut microbiome in offspring neurodevelopment in humans

EBioMedicine, Journal Year: 2023, Volume and Issue: 90, P. 104491 - 104491

Published: March 1, 2023

It has been widely recognized that a critical time window for neurodevelopment occurs in early life and the host's gut microbiome plays an important role neurodevelopment. Following recent demonstrations maternal prenatal influences offspring brain development murine models, we aim to explore whether association between is or postnatal human.Here leverage large-scale human study compare associations microbiota metabolites from mothers during pregnancy their children with children's Specifically, using multinomial regression integrated Songbird, assessed discriminating power of child at as measured by Ages & Stages Questionnaires (ASQ).We show more relevant than first year (maximum Q2 = 0.212 0.096 separately taxa class level). Moreover, found Fusobacteriia associated high fine motor skills ASQ but become low infant (rank 0.084 -0.047 separately), suggesting roles same respect can be opposite two stages fetal neurodevelopment.These findings shed light, especially terms timing, on potential therapeutic interventions prevent neurodevelopmental disorders.This work was supported National Institutes Health (grant numbers: R01AI141529, R01HD093761, RF1AG067744, UH3OD023268, U19AI095219, U01HL089856, R01HL141826, K08HL148178, K01HL146980), Charles A. King Trust Postdoctoral Fellowship.

Language: Английский

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Role of stress in skin diseases: A neuroendocrine-immune interaction view

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 116, P. 286 - 302

Published: Dec. 20, 2023

Psychological stress is a crucial factor in the development of many skin diseases, and stigma caused by disorders may further increase psychological burden, forming vicious cycle leading to diseases. Therefore, understanding relationship between diseases necessary. The skin, as vital interface with external environment, possesses its own complex immune system, neuroendocrine system plays central role response body. Stress-induced alterations can also disrupt delicate balance cells inflammatory mediators dysregulation increased susceptibility various Stress affect barrier function, impair wound healing, promote release pro-inflammatory cytokines, thereby exacerbating existing such psoriasis, atopic dermatitis, acne, urticaria. In present review, we explored intricate from neuroendocrine-immune interaction perspective. We occurrence context stress, models for impact on function relevant epidemiological studies clinical trials. Understanding perspective provides comprehensive framework targeted interventions new insights into diagnosis treatment

Language: Английский

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Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae

Psychopharmacology, Journal Year: 2024, Volume and Issue: 241(4), P. 785 - 803

Published: Feb. 5, 2024

Language: Английский

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The chronic unpredictable mild stress (CUMS) Paradigm: Bridging the gap in depression research from bench to bedside

Brain Research, Journal Year: 2024, Volume and Issue: 1843, P. 149123 - 149123

Published: Nov. 1, 2024

Language: Английский

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Effect of combined chronic predictable and unpredictable stress on depression-like symptoms in mice

Annals of Translational Medicine, Journal Year: 2020, Volume and Issue: 8(15), P. 942 - 942

Published: Aug. 1, 2020

Mental stress mainly induces depression, and predictable stress, as well a constant bombardment of chronic unpredictable micro-stressors, always coexist in daily life. However, the combined effect on depression is still not fully understood.The restraint (CRS) to restrain mice for 6 h per day 3 weeks, mild (CUMS) stimulate with 7 different stressors weeks. We evaluated CRS CUMS depression-like symptoms using behavioral tests investigated action mechanism through analysis neurotransmitters, brain-derived factors, inflammatory antioxidants, intestinal microorganisms.Our data suggested caused significant weight loss, food intake reduction, behaviors-including anhedonia, learned helplessness, reduction spontaneous activity-and even atrophy severe structural damage hippocampus mice. Our pathogenesis study showed that stress-induced glucocorticoid receptor (GR) levels, loss oligodendrocytes (NG2 Olig2 cells), inhibition neuron proliferation CA1, CA3, DG regions hippocampus, decreased contents monoamine neurotransmitters (5-HT NE) BDNF cerebral cortex, hyperactivity HPA system, led immune dysfunction, aggravated oxidative weakened capacity antioxidants Compared single gave rise more diversity change gut microbiota.Combined behaviors, atrophy, via neurotransmitter, BDNF, axis, neurogenesis, neurodegenerative, immune, gut-brain axis pathways.

Language: Английский

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Oral administration ofLactococcus lactisWHH2078 alleviates depressive and anxiety symptoms in mice with induced chronic stress

Food & Function, Journal Year: 2021, Volume and Issue: 13(2), P. 957 - 969

Published: Dec. 23, 2021

Depression is a mood disorder with high prevalence rate globally, which associated abnormalities in 5-hydroxytryptamine (5-HT) metabolism. Emerging evidence suggests that certain probiotics modulate 5-HT metabolism confer beneficial effects on depression. In this study, vitro enterochromaffin RIN14B cells were used for screening potential antidepressant probiotic Lactococcus lactis strains. The L. strain WHH2078 increased to levels the precursor 5-hydroxytryptophan (5-HTP) and expression of tryptophan hydroxylase 1 (Tph1), converts 5-HTP cells. oral administration (1 × 109 CFU mL-1) mice induced chronic unpredictable mild stress (CUMS) 5 weeks significantly ameliorated depressive anxiety-like behaviors tail suspension test, forced swim sucrose preference open field test. Besides, reduced serum corticosterone level restored central 5-HT, 5-HTP, brain-derived neurotrophic factor CUMS-induced mice. Moreover, also reversed colon, accompanied by an upregulation colonic Tph1 gene expression. Using 16S rRNA high-throughput sequencing feces, was shown improve gut microbial dysbiosis, through restoring alpha diversity abundances Firmicutes Bacteroidetes. summary, these results indicate can alleviate rodent response CUMS, improvement modulation microbiome composition. Therefore, supplementation properties may serve as promising therapeutic strategy stress-induced

Language: Английский

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Jasmine Tea Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-like Behavior in Rats via the Gut-Brain Axis

Nutrients, Journal Year: 2021, Volume and Issue: 14(1), P. 99 - 99

Published: Dec. 27, 2021

The number of depressed people has increased worldwide. Dysfunction the gut microbiota been closely related to depression. mechanism by which jasmine tea ameliorates depression via brain-gut-microbiome (BGM) axis remains unclear. Here, effects on rats with depressive-like symptoms microbiome were investigated. We first established a chronic unpredictable mild stress (CUMS) rat model induce depressive and measured changes in depression-related indicators. Simultaneously, investigated 16S rRNA sequencing. Jasmine treatment improved behaviors neurotransmitters CUMS rats. diversity richness induced CUMS. Spearman's analysis showed correlations between differential (Patescibacteria, Firmicutes, Bacteroidetes, Spirochaetes, Elusimicrobia, Proteobacteria) depressive-related indicators (BDNF, GLP-1, 5-HT hippocampus cerebral cortex). Combined correlation microbiota, result indicated that could attenuate brain- gut-microbiome axis.

Language: Английский

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Indole Acetic Acid Exerts Anti-Depressive Effects on an Animal Model of Chronic Mild Stress

Nutrients, Journal Year: 2022, Volume and Issue: 14(23), P. 5019 - 5019

Published: Nov. 25, 2022

Indole acetic acid (IAA), an intestinal bacteria-derived tryptophan metabolite, has been detected at abnormal concentrations in the cerebrospinal fluid and urine of depressed individuals. The effects such altered IAA on mood regulation are not known. A mouse model unpredictable chronic mild stress (UCMS) was used to assess administration (50 mg/kg). Treatment with for 5 weeks attenuated depression anxiety-like behaviours, improved hypothalamus-pituitary-adrenal axis dysfunction increased brain-derived neurotrophic factor expression. supplementation also enhanced serotonin pathway brain gut. UCMS caused imbalance microbial indole metabolites colon, whereas treatment reversed this. However, intake did affect indoles brain. Intestinal bacteria different sections gut were by treatment, colon showing more changes than other segments. microbiome had proportions Ruminococcaceae UCG013, Ruminiclostridium 6, Prevotella, Alloprevotella Bacteroides species, which can produce short-chain fatty acids derivatives. Cumulatively, our study highlights potential alleviate disorders offers a theoretical basis understanding antidepressant IAA.

Language: Английский

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