Obeticholic Acid Inhibits Anxiety via Alleviating Gut Microbiota-Mediated Microglia Accumulation in the Brain of High-Fat High-Sugar Diet Mice DOI Open Access
Li Wu,

Yuqiu Han,

Zhipeng Zheng

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(3), P. 940 - 940

Published: March 15, 2021

Anxiety is one of the complications metabolic disorders (MDs). Obeticholic acid (OCA), bile acids (BAs) derivative, a promising agent for improving MDs in association with gut dysbiosis. Yet, its protective effect on MDs-driven anxiety remains unknown. Here, we assessed serum biochemical parameters and behavioral performance by open field Morris water maze tests HFHS diet-induced mice after OCA intervention nine 18 weeks. Moreover, antibiotics microbial depletion was conducted simultaneously. We found that treatment inhibited initiation progression diet-MDs via microbiota–BAs–brain axis: decreased neuroinflammatory microglia IL-1β expression hippocampus, reversed intestinal barrier dysfunction proinflammatory LPS to normal level, modified community, including known anxiety-related Rikenellaceae Alistipes, improved metabolites especially increased BAs feces circulation. OCA-reversed taurocholate linked disordered lipid indole derivatives as network analysis. Additionally, also anxiety, microgliosis enrichment experimental mice. Together, these findings provide axis novel therapeutic target MDs-associated neuropsychiatric disorders.

Language: Английский

Combined probiotics attenuate chronic unpredictable mild stress-induced depressive-like and anxiety-like behaviors in rats DOI Creative Commons

Li Huang,

Xia Lv,

Xiaolei Ze

et al.

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 7, 2022

Increasing evidence indicated that probiotics can be effective in improving behaviors similar to depression and anxiety disorders. However, the underlying mechanisms remain unclear, as is effects of single vs. combined on anxiety. This study aimed determine whether could attenuate depressive-like anxiety-like behavior induced by chronic unpredictable mild stress (CUMS) its potential mechanisms. Rats underwent CUMS treatment then administered Lactobacillus rhamnosus HN001 (HN001) or Bifidobacterium animalis subsp. lactis HN019 (HN019), alone combination. Levels neurotransmitters, inflammatory factors, gut microbiota were measured. (or) improved rats, including increased moving distance exploratory (p < 0.05). In addition, altered structure was amended and/or intervention also remarkably normalized levels 5-HT, DA, NE, HVA, DOPAC, HIAA, TNF-α, IL-6, IL-18 IL-1β rats Furthermore, decreasing inflammation (Chao1 index ACE index, p 0.05) superior probiotics. Moreover, spearman analysis showed a certain correlation between different microbiota, such Firmicutes, Bacteroidetes, Verrucomicrobias, Proteobacterias Actinobacterias, neurotransmitters. These findings suggested depressive alleviated combination probiotics, which possibly associated with alterations composition neurotransmitters decreased factors.

Language: Английский

Citations

28
Stress-Related Dysfunction of Adult Hippocampal Neurogenesis—An Attempt for Understanding Resilience? DOI Open Access
Julia Leschik, Beat Lutz, Antonietta Gentile

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(14), P. 7339 - 7339

Published: July 8, 2021

Newborn neurons in the adult hippocampus are regulated by many intrinsic and extrinsic cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of neurogenesis, which this review discusses as one reason why psychiatric diseases, such major depression, develop after long-term stress exposure. In reverse, neurogenesis has been suggested protect against stress-induced hence, could serve a resilience mechanism. review, we will summarize current knowledge about functional relation health disease. A special focus lie on mechanisms underlying cascades events from prolonged high concentrations reduced numbers newborn neurons. addition neurotransmitter neurotrophic factor dysregulation, these include immunomodulatory pathways, microbiota changes influencing gut-brain axis. Finally, discuss recent findings delineating role resilience.

Language: Английский

Citations

36
Acetylcholine promotes chronic stress-induced lung adenocarcinoma progression via α5-nAChR/FHIT pathway DOI
Yang Jiao,

Guiyu Kang,

Pan Pan

et al.

Cellular and Molecular Life Sciences, Journal Year: 2023, Volume and Issue: 80(5)

Published: April 7, 2023

Language: Английский

Citations

14
The role and mechanism of TGF-β1 in the antidepressant-like effects of tetrahydrocurcumin DOI
Yan Yang, Jianyu Yang,

Tengteng Ma

et al.

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 959, P. 176075 - 176075

Published: Oct. 5, 2023

Language: Английский

Citations

13
Du-moxibustion ameliorates depression-like behavior and neuroinflammation in chronic unpredictable mild stress-induced mice DOI Creative Commons

Zhixia Jia,

Wenyan Yu, Xuhao Li

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 358, P. 211 - 221

Published: May 3, 2024

Neuroinflammation is involved in the advancement of depression. Du-moxibustion can treat Here, we explored whether could alleviate neuroglia-associated neuro-inflammatory process chronic unpredictable mild stress (CUMS) mice.

Language: Английский

Citations

4
Relationship Between Depression and Epigallocatechin Gallate from the Perspective of Gut Microbiota: A Systematic Review DOI Open Access
Yangbo Zhang,

Chang-Wei Liu,

Qi Zhu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 259 - 259

Published: Jan. 12, 2025

Depression, a serious mental illness, is characterized by high risk, incidence, persistence, and tendency to relapse, posing significant burden on global health. The connection between depression gut microbiota an emerging field of study in psychiatry neuroscience. Understanding the gut–brain axis pivotal for understanding pathogenesis treatment depression. Gut microbes influence depression-like behaviors impacting hypothalamic–pituitary–adrenal (HPA), monoamine neurotransmitters, immune responses, cell signaling, metabolic pathways. Tea, widely used clinical practice improve neuropsychiatric disorders, contains Epigallocatechin gallate (EGCG), major ingredient green tea, which effectively regulates intestinal flora. This review examined risks causes depression, complications associated with flora, their role development how EGCG may alleviate through interactions other mechanisms.

Language: Английский

Citations

0
Dorsal bed nucleus of the stria terminalis GABA neurons are necessary for chronic unpredictable stress-induced depressive behaviors in adolescent male mice DOI
Wenjing Hu,

Qiyuan Wang,

Lixia Jiang

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 182, P. 347 - 357

Published: Jan. 18, 2025

Language: Английский

Citations

0
Bifidobacterium breve BB05 alleviates depressive symptoms in mice via the AKT/mTOR pathway DOI Creative Commons
Yuqin Pan,

Qianhua Huang,

Yuan Liang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 30, 2025

Introduction This study investigates the potential of Bifidobacterium breve BB05 (BB05) in mitigating depressive symptoms a mouse model Chronic Unpredictable Mild Stress (CUMS), with fluoxetine as positive control. Methods and Results High-dose (1.0 × 10 9 CFU/kg, BB05H) significantly reduced anxiety- depression-like behaviors CUMS mice, measured by open field test, tail suspension forced swim test. treatment also pathological ileal damage, alleviated inflammation, lowered serum levels pro-inflammatory cytokines IL-6 TNF-α. Additionally, increased 5-HT decreased ACTH concentrations. Mechanistic analysis revealed that exerts antidepressant effects activating AKT/mTOR signaling pathway prefrontal cortex, promoting neuroprotection, neurogenesis, synaptic plasticity. Discussion These findings suggest BB05, particularly at higher doses, effectively alleviates CUMS-induced improves physiological outcomes, supporting use probiotics for depression targeting pathway.

Language: Английский

Citations

0
Antidepressant Effect of Crossopteryx Febrifuga Trunk Bark Aqueous Extract on Chronic Stress-Induced Depression in Rodents: A Sex-Based Approach DOI

Daniel Ndavoumta,

Harquin Simplice Foyet, Camdi Woumitna Guillaume

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
A study on the differences in the gut microbiota and metabolism between male and female mice in different stress periods DOI Creative Commons
Yajun Qiao,

Juan Guo,

Qi Xiao

et al.

Experimental Biology and Medicine, Journal Year: 2025, Volume and Issue: 250

Published: Feb. 11, 2025

The sex difference in depression has long been an unsolved issue. Women are twice as likely to suffer from men. However, there were significant differences the composition of gut microbiota between women and There is a lack studies linking microbiota, specific mechanisms this process have not explained detail. main purpose study was explore gender intestinal tract male female depressed mice. In study, chronic restraint stress (CRS) mouse models used simulate stress, behavioral tests conducted, including open field test (OFT), tail suspension (TST) forced swimming (FST). Microbial diversity analysis metabolomics performed on collected feces. results showed that mice highly active prone anxious behavior before levels f-Rikenellaceae, f-Ruminococcaceae 16α-hydroxyestrone significantly different those After 21 days (Days) depression-like behavior, f-Erysipelotrichaceae , 5α-pregnane-3,20-dione, 2-hydroxyestradiol 14 withdrawal, continued worsen mice, estrone glucuronide summary, stronger sensitivity weaker resilience than which may be related bacterial estrogen metabolism disorders.

Language: Английский

Citations

0