PitNETs and the gut microbiota: potential connections, future directions DOI Creative Commons

Ding Nie,

Chuzhong Li,

Yazhuo Zhang

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 6, 2023

The role of the gut microbiome has been widely discussed in numerous works literature. biggest concern is association with central nervous system through microbiome-brain-gut axis past ten years. As more and research done on relationship between disease microbes. This fact being revealed that microbes seem to play an important from onset progression clinical symptoms, new treatments. a special tumor system, pituitary neuroendocrine tumors (PitNETs)are closely related metabolism, endocrinology, immunity. These factors are vectors which intestinal interact system. However, little known about effects PitNET. In this review, microbiota PitNETs introduced, potential gut-brain analyzed, future directions presented.

Language: Английский

The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective DOI Creative Commons
Sarah‐Jane Leigh, Friederike Uhlig, Lars Wilmes

et al.

The Journal of Physiology, Journal Year: 2023, Volume and Issue: 601(20), P. 4491 - 4538

Published: Sept. 27, 2023

The physiological consequences of stress often manifest in the gastrointestinal tract. Traumatic or chronic is associated with widespread maladaptive changes throughout gut, although comparatively little known about effects acute stress. Furthermore, these stress-induced gut may increase susceptibility to disorders and infection, impact critical features neural behavioural response by impairing gut-brain axis communication. Understanding mechanisms behind enteric nervous system circuitry, visceral sensitivity, barrier function, permeability, microbiota following an important research objective pathophysiological implications both neurogastroenterology psychiatry. Moreover, has emerged as a key aspect physiology sensitive In this review, we focus on different aspects tract including function well immune, humoral neuronal elements involved discuss evidence for role disorders. Existing gaps current literature are highlighted, possible avenues future integrated perspective have been suggested. A more complete understanding spatial temporal dynamics host microbial kinds stressors will enable full exploitation diagnostic therapeutic potential fast-evolving field host-microbiome interactions.

Language: Английский

Citations

47
Effect of prebiotics, probiotics, synbiotics on depression: results from a meta-analysis DOI Creative Commons
Qin Zhang, Bing Chen, Jinghui Zhang

et al.

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: June 29, 2023

Accumulating studies have shown the effects of gut microbiota management tools in improving depression. We conducted a meta-analysis to evaluate prebiotics, probiotics, and synbiotics on patients with searched six databases up July 2022. In total, 13 randomized controlled trials (RCTs) 786 participants were included. The overall results demonstrated that who received probiotics or had significantly improved symptoms depression compared those placebo group. However, subgroup analysis only confirmed significant antidepressant agents contained probiotics. addition, mild moderate could both benefit from treatment. Studies lower proportion females reported stronger for alleviating depressive symptoms. conclusion, manipulate might improve mild-to-moderate It is necessary further investigate benefits prebiotic, probiotic synbiotic treatments relative antidepressants follow individuals over longer time before these therapies are implemented clinical practice.

Language: Английский

Citations

40
Lactobacillus casei and Its Supplement Alleviate Stress-Induced Depression and Anxiety in Mice by the Regulation of BDNF Expression and NF-κB Activation DOI Open Access
Xiaoyang Ma, Yoon-Jung Shin,

Hee-Seo Park

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(11), P. 2488 - 2488

Published: May 26, 2023

Stress-induced depression and anxiety (DA) are closely connected to gastrointestinal inflammation dysbiosis, which can suppress brain-derived neurotrophic factor (BDNF) in the brain. Herein, we isolated BDNF expression-inducing probiotics Lactobacillus casei HY2782 Bifidobacterium lactis HY8002 lipopolysaccharide-stimulated SH-SY5Y cells. Then, investigated effects of HY2782, HY8002, anti-inflammatory L-theanine, their supplement (PfS, probiotics-fermented L-theanine-containing supplement) on DA mice exposed restraint stress (RS) or fecal microbiota patients with inflammatory bowel disease (FMd). Oral administration L-theanine alleviated RS-induced DA-like behaviors. They also decreased hippocampal interleukin (IL)-1β IL-6 levels, as well NF-κB-positive cell numbers, blood corticosterone level, colonic IL-1β levels numbers. more potently suppressed behaviors inflammation-related marker than probiotics. However, these increased RS-suppressed level BDNF+NeuN+ numbers L-theanine. Furthermore, RS-increased Proteobacteria Verrucomicrobia populations gut microbiota. In particular, they Lachnospiraceae Lactobacillacease populations, positively associated expression, Sutterellaceae, Helicobacteriaceae, Akkermansiaceae, Enterobacteriaceae expression. FMd-induced FMd-suppressed BDNF, serotonin BDNF-positive neuronal α levels. weakly, but not significantly, inflammation. probiotic (HY2782, Streptococcus thermophilus, acidophilus)-fermented PfS behaviors, biomarker dysbiosis Based findings, a combination may additively synergistically alleviate by regulating microbiota-mediated thereby being beneficial for DA.

Language: Английский

Citations

23
BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis DOI Creative Commons

Somaieh Matin,

Masoomeh Dadkhah

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 207, P. 110882 - 110882

Published: Jan. 19, 2024

Emerging evidence supports the gut microbiota and brain communication in general health. This axis may affect behavior through modulating neurotransmission, thereby involve pathogenesis and/or progression of different neuropsychiatric disorders such as depression. Brain-derived neurotrophic factor cAMP response element-binding protein known CREB/BDNF pathway plays have critical functions depression same mechanisms related to antidepressants. However, putative causal significance signaling cascade gut-brain remains unknown. Also interventions probiotics supplementation exercise can influence microbiome also improve bidirectional brain. In this review we aim explain BDNF/CREB dysfunction then evaluate potential role probiotics, prebiotics, a therapeutic target induced The current narrative will specifically focus on impact diet intestinal component, well effect that these therapies alleviate depressive symptoms. Finally, look at how exert distinct effects dysfunction.

Language: Английский

Citations

14
Gut microbiota decreased inflammation induced by chronic unpredictable mild stress through affecting NLRP3 inflammasome DOI Creative Commons

Li Huang,

Zewei Ma,

Xiaolei Ze

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: May 24, 2023

Dysbiosis of the gut microbiota is associated with development depression, but underlying mechanism remains unclear. The aim this study was to determine relationship between and NLRP3 inflammasome induced by chronic unpredictable mild stress (CUMS). Fecal transplantation (FMT) experiment conducted elucidate potential mechanism. Levels inflammasome, microbiota, inflammatory factors tight junction proteins were measured. CUMS stimulation significantly increased levels NLRP3, Caspase-1 ASC in brain colon( p <0.05), decreased Occludin ZO-1 ( <0.05). Interestingly, cytokines found antibiotic-treated (Abx) rats received rat fecal transplantation. Furthermore, altered Abx rats, which partially overlapped that donor rats. Importantly, probiotic administration amended alteration treatment, then reduced factors. In conclusion, these findings suggested depression-like behaviors related broke intestinal barrier, promoted expression elevated inflammation. Therefore, improving composition via can attenuate inflammation amending suppressing activation considered as a novel therapeutic strategy for depression.

Language: Английский

Citations

17
Maternal probiotic Lactocaseibacillus rhamnosus HN001 treatment alters postpartum anxiety, cortical monoamines, and the gut microbiome DOI
Joseph S. Lonstein,

Taryn A. Meinhardt,

Pavlina Pavlidi

et al.

Psychoneuroendocrinology, Journal Year: 2024, Volume and Issue: 165, P. 107033 - 107033

Published: March 19, 2024

Language: Английский

Citations

8
Deciphering the antidepressant effects of Rosa damascena essential oil mediated through the serotonergic synapse signaling pathway DOI
Xia Ning,

Jie Wang,

Qiuting Guo

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 328, P. 118007 - 118007

Published: March 15, 2024

Language: Английский

Citations

5
Bacillus coagulans and Clostridium butyricum synergistically alleviate depression in a chronic unpredictable mild stress mouse model through altering gut microbiota and prefrontal cortex gene expression DOI Creative Commons

Jingyi Xu,

Lei Zhou, Zhaowei Chen

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 23, 2024

Introduction: The prevalence of major depressive disorder (MDD) has gradually increased and attracted widespread attention. aim this study was to investigate the effect a probiotic compound consisting Bacillus coagulans Clostridium butyricum , on mouse depression model. Methods: Mice were subjected chronic unpredictable mild stress (CUMS) then treated with probiotics at different concentrations. And mice received behavior test such as forced swimming tail suspension test. After that, all sacrificed samples collected for analysis. Moreover, prefrontal cortex (PFC) gene expression gut microbiota among groups also analyzed. Results: Probiotics improved depressive-like in CUMS mice, indicated by decreased immobility time ( p < 0.05) intervention level 5-hydroxytryptamine (5-HT) adrenocorticotropic hormone (ACTH) serum. In addition, comparing PFC groups, we found that genes upregulated enriched PI3K-Akt signaling pathway cortex. downregulated group Sfrp5 Angpt2 which correlated depression, reversed probiotics. Furthermore, altered structure microbiota, reduction cob(II)yrinate a,c-diamide biosynthesis I group. Several species like Bacteroides caecimuris Parabacteroides distasoni, whose abundance significantly but after intervention, showed positive correlation associated Tbxas1 Cldn2 . Discussion: These findings suggested CUMS-induced depression-like can be alleviated probiotics, possibly through alterations microbiota.

Language: Английский

Citations

4
Exploring the Mechanism of Treating IBS from the “Gallbladder” Based on Regulating Gut Microbiota DOI

霞 杨

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 441 - 448

Published: Jan. 1, 2025

Language: Английский

Citations

0
Resveratrol Ameliorates Chronic Stress in Kennel Dogs and Mice by Regulating Gut Microbiome and Metabolome Related to Tryptophan Metabolism DOI Creative Commons
Zhaowei Bian, Ziyang Li, Hao Chang

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 195 - 195

Published: Feb. 9, 2025

Chronic stress poses threats to the physical and psychological well-being of dogs. Resveratrol (Res) is a polyphenol with antidepressant properties has rarely been studied in This study aimed investigate stress-relieving effects underlying mechanism Res Dogs were fed basal diet supplemented for 35 days. The fecal microbiota dogs was cultured vitro. results show that improved stress-related behaviors increased serum levels 5-hydroxytryptamine (5-HT), brain-derived neurotrophic factor (BDNF), immunoglobulin A, antioxidant capacity downregulated hormones hypothalamic–pituitary–adrenal axis. abundance butyric-producing bacteria, like Blautia, increased, while growth Fusobacterium related gut inflammation inhibited group. A higher content butyric acid observed metabolome indicated tryptophan (Trp) decreased consumption Trp by microorganisms. chronic unpredictable mild mouse model established, administered ameliorated behavior 5-HT whole brains mice. relative mRNA expression genes associated tight junction protein, aryl hydrocarbon receptor, transporters colon upregulated. In conclusion, could ameliorate canine increasing 5-HT, BDNF, improving immune function response, which attributed role restructuring modulation metabolism.

Language: Английский

Citations

0