Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy DOI Open Access
Fahad Khan, Pratibha Pandey, Meenakshi Verma

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116363 - 116363

Published: March 12, 2024

Ferroptosis, a novel form of regulated cell death characterized by dependence on iron and lipid peroxidation, has been implicated in wide range clinical conditions including neurological diseases, cardiovascular disorders, acute kidney failure, various types cancer. Therefore, it is critical to suppress cancer progression proliferation. Ferroptosis can be triggered cells some normal synthetic substances, such as erastin, Ras-selective lethal small molecule-3, or pharmaceuticals. Natural bioactive compounds are traditional drug discovery tools, have therapeutically used dietary additives pharmaceutical agents against malignancies. The fact that natural products multiple targets minimal side effects led notable advances anticancer research. Research indicated ferroptosis also induced during treatment. In this review, we focused the most recent developments emerging molecular processes significance To provide new perspectives future development ferroptosis-related medications, summary implications phytochemicals triggering through ROS production ferritinophagy induction variety

Language: Английский

NRF2 Deficiency Promotes Ferroptosis of Astrocytes Mediated by Oxidative Stress in Alzheimer’s Disease DOI
Zhi Tang,

Zhuyi Chen,

Min Guo

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(10), P. 7517 - 7533

Published: Feb. 24, 2024

Language: Английский

Citations

25
Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors DOI Creative Commons

Carolina Punziano,

Silvia Trombetti, Elena Cesaro

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 298 - 298

Published: Feb. 28, 2024

Ferroptosis is a type of programmed cell death that differs from apoptosis, autophagy, and necrosis related to several physio-pathological processes, including tumorigenesis, neurodegeneration, senescence, blood diseases, kidney disorders, ischemia–reperfusion injuries. linked iron accumulation, eliciting dysfunction antioxidant systems, which favor the production lipid peroxides, membrane damage, ultimately, death. Thus, signaling pathways evoking ferroptosis are strongly associated with those protecting cells against excess and/or lipid-derived ROS. Here, we discuss interaction between metabolic particular focus on transcription factors implicated in regulation ferroptosis, either as triggers peroxidation or defense pathways.

Language: Английский

Citations

18
Magnolia kobus DC. suppresses neointimal hyperplasia by regulating ferroptosis and VSMC phenotypic switching in a carotid artery ligation mouse model DOI Creative Commons
Jong Min Kim, Yiseul Kim,

Hyun-Jin Na

et al.

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 3, 2025

Abstract Background Magnolia kobus DC (MO), as a plant medicine, has been reported to have various physiological activities, including neuroprotective, anti-inflammatory, and anti-diabetic effects. However, vascular protective effects of MO remain incompletely understood. In this study, we evaluated the effect against ferroptosis in carotid artery ligation (CAL)-induced neointimal hyperplasia mouse model aortic thoracic smooth muscle A7r5 cells. Methods This study was conducted estimate by systematically measuring histopathological analysis western blot CAL animal model. vitro were estimating cell viability, reactive oxygen species (ROS) content, glutathione (GSH) levels, lipid peroxidation, mitochondrial morphological change, proliferation, migration, analysis, qRT-PCR erastin (Era)-induced Results intake significantly improved formation, inhibited (VSMC) phenotypes, ameliorated antioxidant system tissues. addition, treatment effectively Era-induced ferroptotic cytotoxicity, cellular death, ROS production, migration status. also suppressed proliferation considerably regulated abnormal mechanisms related changes, VSMC phenotype switching, scavenging Conclusion potential for use functional food supplement, nutraceutical, or medicinal food, with on health regulating phenotypic switching.

Language: Английский

Citations

2
NNMT is involved in deoxynivalenol-induced hepatocyte toxicity via promoting ferroptosis DOI
Weiling Huang,

Chenchen Song,

Yu Hua

et al.

Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 154084 - 154084

Published: Feb. 1, 2025

Language: Английский

Citations

2
Mechanisms of Ferroptosis and Emerging Links to the Pathology of Neurodegenerative Diseases DOI Creative Commons
Yiyan Sun, Xiaohuan Xia, Diksha Basnet

et al.

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: June 28, 2022

Neurodegenerative diseases are a diverse class of attributed to chronic progressive neuronal degeneration and synaptic loss in the brain and/or spinal cord, including Alzheimer’s disease, Parkinson’s Huntington’s amyotrophic lateral sclerosis multiple sclerosis. The pathogenesis neurodegenerative is complex diverse, often involving mitochondrial dysfunction, neuroinflammation, epigenetic changes. However, has not been fully elucidated. Recently, accumulating evidence revealed that ferroptosis, newly discovered iron-dependent lipid peroxidation-driven type programmed cell death, provides another explanation for occurrence progression diseases. Here, we provide an overview process regulation mechanisms summarize current research progresses support contribution ferroptosis A comprehensive understanding emerging roles will shed light on development novel therapeutic technologies strategies slowing down these

Language: Английский

Citations

65
The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components DOI Open Access
Kailin Yang,

Liuting Zeng,

Xiao Yuan

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 154, P. 113611 - 113611

Published: Sept. 5, 2022

Cerebrovascular diseases, such as ischemic stroke, pose serious medical challenges worldwide due to their high morbidity and mortality limitations in clinical treatment strategies. Studies have shown that reactive oxygen species (ROS)-mediated inflammation, excitotoxicity, programmed cell death of each neurovascular unit during post-stroke hypoxia reperfusion play an important role the pathological cascade. Ferroptosis, a characterized by iron-regulated accumulation lipid peroxidation, is caused abnormal metabolism lipids, glutathione (GSH), iron, can accelerate acute central nervous system injury. Recent studies gradually uncovered process ferroptosis stroke. Some drugs iron chelators, ferrostatin-1 (Fer-1) liproxstatin-1 (Lip-1) protect nerves after injury stroke inhibiting ferroptosis. In addition, combined with our previous on mediated natural compounds this review summarized progress regulation mechanism chemical components herbal recent years, order provide reference information for future research lead development inhibitors.

Language: Английский

Citations

58
Engineering dual catalytic nanomedicine for autophagy-augmented and ferroptosis-involved cancer nanotherapy DOI
Zhifang Li, Chunmei Wang,

Chen Dai

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 287, P. 121668 - 121668

Published: July 5, 2022

Language: Английский

Citations

57
Ferroptosis and its interaction with tumor immune microenvironment in liver cancer DOI
Yilan Huang, Siwei Wang, Ai‐Wu Ke

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2022, Volume and Issue: 1878(1), P. 188848 - 188848

Published: Dec. 9, 2022

Language: Английский

Citations

50
Trabectedin induces ferroptosis via regulation of HIF-1α/IRP1/TFR1 and Keap1/Nrf2/GPX4 axis in non-small cell lung cancer cells DOI Open Access

Shunv Cai,

Zewu Ding,

Xinyi Liu

et al.

Chemico-Biological Interactions, Journal Year: 2022, Volume and Issue: 369, P. 110262 - 110262

Published: Nov. 14, 2022

Language: Английский

Citations

45
From Iron Metabolism to Ferroptosis: Pathologic Changes in Coronary Heart Disease DOI Creative Commons
Xinbiao Fan, Aolin Li, Zhipeng Yan

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 14

Published: Aug. 10, 2022

Coronary heart disease (CHD) is closely related to oxidative stress and inflammatory response the most common cardiovascular (CVD). Iron an essential mineral that participates in many physiological biochemical reactions human body. Meanwhile, on negative side, iron has active redox capacity, which leads accumulation of reactive oxygen species (ROS) lipid peroxidation. There growing evidence disordered metabolism involved CHD’s pathological progression. And result associated with overload-induced programmed cell death, often called ferroptosis. That features iron-dependent Ferroptosis may play a crucial role development CHD, targeting ferroptosis be promising option for treating CHD. Here, we review mechanisms cardiomyocytes (CMs) explain correlation between highlight specific roles main progression

Language: Английский

Citations

40