Nanotechnology connecting copper metabolism and tumor therapy DOI Creative Commons

Yongjuan Li,

Ya Dong,

Xinyao Zhou

et al.

MedComm – Biomaterials and Applications, Journal Year: 2023, Volume and Issue: 2(2)

Published: April 14, 2023

Abstract Copper (Cu) is an essential trace element in the human body that involved formation of several natural enzymes, such as superoxide dismutase and cyclooxygenase. Due to high density outer electron cloud Cu, which allows transfer multiple electrons, Cu often used catalytic center various metabolic enzymes. However, both deficiency excessive accumulation can result irreversible damage cells. Therefore, strategies regulate metabolism, exhaustion supplementation, have emerged attractive approaches anticancer therapy, due potential damages caused by metabolism disorders. Notably, recent advancements nanotechnology enabled development nanomaterials making this therapy applicable vivo. In review, we provide a systematic discussion physical chemical properties summarize applications metabolism‐based antitumor therapy. Finally, outline future directions challenges nano‐Cu emphasizing scientific problems technical bottlenecks need be addressed for successful clinical translation.

Language: Английский

Autophagy and cancer drug resistance in dialogue: Pre-clinical and clinical evidence DOI
Yi Qin, Milad Ashrafizadeh, Vera Mongiardini

et al.

Cancer Letters, Journal Year: 2023, Volume and Issue: 570, P. 216307 - 216307

Published: July 12, 2023

Language: Английский

Citations

153
Ferroptosis as a potential target for cancer therapy DOI Creative Commons
Zhen Chen, Weilong Wang, Siti Razila Abdul Razak

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(7)

Published: July 24, 2023

Abstract Ferroptosis is a recently discovered essential type of cell death that mainly characterized by iron overload and lipid peroxidation. Emerging evidence suggests ferroptosis double-edged sword in human cancer. However, the precise underlying molecular mechanisms their differential roles tumorigenesis are unclear. Therefore, this review, we summarize briefly present key pathways ferroptosis, paying special attention to regulation as well its dual role an oncogenic tumor suppressor event various cancers. Moreover, multiple pharmacological activators summarized, prospect targeting cancer therapy further elucidated.

Language: Английский

Citations

105
Autophagy-Dependent Ferroptosis in Cancer DOI
Fangquan Chen,

Xiutao Cai,

Rui Kang

et al.

Antioxidants and Redox Signaling, Journal Year: 2023, Volume and Issue: 39(1-3), P. 79 - 101

Published: Feb. 3, 2023

Significance: Autophagy is a self-degrading process that determines cell fate in response to various environmental stresses. In contrast autophagy-mediated survival, the signals, mechanisms, and effects of autophagy-dependent death remain obscure. The discovery ferroptosis provides paradigm for understanding relationship between aberrant degradation pathways excessive lipid peroxidation driving regulated death. Recent Advances: Ferroptosis was originally described as an autophagy-independent iron-mediated nonapoptotic Current studies reveal level intracellular autophagy positively correlated with sensitivity. Selective autophagic proteins (e.g., ferritin, SLC40A1, ARNTL, GPX4, CDH2) or organelles droplets mitochondria) promotes by inducing iron overload and/or peroxidation. Several upstream autophagosome regulators TMEM164), downstream receptors HPCAL1), danger signals DCN) are selectively required ferroptosis-related autophagy, but not starvation-induced autophagy. induction effective approach eliminate drug-resistant cancer cells. Critical Issues: How different activate modulate sensitivity fully understood. Identifying direct protein effectors ferroptotic remains challenge. Future Directions: Further molecular mechanics immune consequences critical development precision antitumor therapies. Antioxid. Redox Signal. 39, 79-101.

Language: Английский

Citations

61
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis DOI Creative Commons
Xin Chen,

Andrey S. Tsvetkov,

Han‐Ming Shen

et al.

Autophagy, Journal Year: 2024, Volume and Issue: 20(6), P. 1213 - 1246

Published: March 6, 2024

Macroautophagy/autophagy is a complex degradation process with dual role in cell death that influenced by the types are involved and stressors they exposed to. Ferroptosis an iron-dependent oxidative form of characterized unrestricted lipid peroxidation context heterogeneous plastic mechanisms. Recent studies have shed light on involvement specific autophagy (e.g. ferritinophagy, lipophagy, clockophagy) initiating or executing ferroptotic through selective anti-injury proteins organelles. Conversely, other forms reticulophagy lysophagy) enhance cellular defense against damage. Dysregulated autophagy-dependent ferroptosis has implications for diverse range pathological conditions. This review aims to present updated definition ferroptosis, discuss influential substrates receptors, outline experimental methods, propose guidelines interpreting results.

Language: Английский

Citations

58
An injectable and active hydrogel induces mutually enhanced mild magnetic hyperthermia and ferroptosis DOI
Xiaobin Chen, Hancheng Wang,

Jiayue Shi

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 298, P. 122139 - 122139

Published: April 27, 2023

Language: Английский

Citations

55
Ferroptosis: principles and significance in health and disease DOI Creative Commons
Fangquan Chen, Rui Kang, Daolin Tang

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: June 6, 2024

Abstract Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed molecular networks involving diverse molecules and organelles. Since its recognition as a non-apoptotic pathway in 2012, ferroptosis has emerged crucial mechanism numerous physiological pathological contexts, leading to significant therapeutic advancements across wide range diseases. This review summarizes the fundamental mechanisms regulatory pathways underlying ferroptosis, including both GPX4-dependent -independent antioxidant mechanisms. Additionally, we examine involvement various conditions, cancer, neurodegenerative diseases, sepsis, ischemia–reperfusion injury, autoimmune disorders, metabolic disorders. Specifically, explore role response chemotherapy, radiotherapy, immunotherapy, nanotherapy, targeted therapy. Furthermore, discuss pharmacological strategies for modulating potential biomarkers monitoring this process. Lastly, elucidate interplay between other forms regulated death. Such insights hold promise advancing our understanding context human health disease.

Language: Английский

Citations

51
Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy DOI Creative Commons
Reyida Aishajiang, Zhongshan Liu, Tiejun Wang

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(5), P. 2303 - 2303

Published: March 1, 2023

Copper serves as a vital microelement which is widely present in the biosystem, functioning multi-enzyme active site, including oxidative stress, lipid oxidation and energy metabolism, where reduction characteristics are both beneficial lethal to cells. Since tumor tissue has higher demand for copper more susceptible homeostasis, may modulate cancer cell survival through reactive oxygen species (ROS) excessive accumulation, proteasome inhibition anti-angiogenesis. Therefore, intracellular attracted great interest that multifunctional copper-based nanomaterials can be exploited diagnostics antitumor therapy. this review explains potential mechanisms of copper-associated death investigates effectiveness biomaterials field

Language: Английский

Citations

45
In situ hydrogel based on Cu–Fe3O4 nanoclusters exploits oxidative stress and the ferroptosis/cuproptosis pathway for chemodynamic therapy DOI
Yiqun Zhang, Ni Zhang,

Jianghao Xing

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122675 - 122675

Published: June 26, 2024

Language: Английский

Citations

29
Progress and Challenges in Tumor Ferroptosis Treatment Strategies: A Comprehensive Review of Metal Complexes and Nanomedicine DOI
Yanhong Su, Bing Liu, Binghan Wang

et al.

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 14, 2024

Abstract Ferroptosis is a new form of regulated cell death featuring iron‐dependent lipid peroxides accumulation to kill tumor cells. A growing body evidence has shown the potential ferroptosis‐based cancer therapy in eradicating refractory malignancies that are resistant apoptosis‐based conventional therapies. In recent years, studies have reported number ferroptosis inducers can increase vulnerability cells by regulating ferroptosis‐related signaling pathways. Encouraged rapid development ferroptosis‐driven therapies, interdisciplinary fields combine ferroptosis, pharmaceutical chemistry, and nanotechnology focused. First, prerequisites metabolic pathways for briefly introduced. Then, detail emerging designed boost ferroptosis‐induced therapy, including metal complexes, metal‐based nanoparticles, metal‐free nanoparticles summarized. Subsequently, application synergistic strategies with apoptosis other emphasis on use both cuproptosis induce redox dysregulation intracellular bimetallic copper/iron metabolism disorders during treatment discussed. Finally, challenges associated clinical translation future directions potentiating therapies highlighted.

Language: Английский

Citations

19
Exploration of Ultrasound‐Sensitive Biomaterials in Cancer Theranostics DOI
Yuqi Yang, Huazheng Liang, Chun Tang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(21)

Published: Jan. 6, 2024

Abstract Cancer is a serious health problem to be solved. With the development of biomaterials, enhanced diagnostic and controllable therapeutic strategies for cancer have emerged, revealing encouraging results with promising future. Due its outstanding tissue penetration controllability, along series bioeffects on tissues, ultrasound (US), as common medical technology, has been regarded an effective tool against cancer, use promoted exploration US‐sensitive biomaterials. In this review, US are first introduced then main biomaterials (containing cavitation nuclei, sonosensitizers, US‐responsive macromolecular systems) used treat followed by summary several applications based from diagnosis therapy. Finally, emerging challenges in field that need overcome highlighted. This review reports progress providing new possibilities theranostics thus benefiting patients.

Language: Английский

Citations

17