Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy DOI Open Access
Fahad Khan, Pratibha Pandey, Meenakshi Verma

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116363 - 116363

Published: March 12, 2024

Ferroptosis, a novel form of regulated cell death characterized by dependence on iron and lipid peroxidation, has been implicated in wide range clinical conditions including neurological diseases, cardiovascular disorders, acute kidney failure, various types cancer. Therefore, it is critical to suppress cancer progression proliferation. Ferroptosis can be triggered cells some normal synthetic substances, such as erastin, Ras-selective lethal small molecule-3, or pharmaceuticals. Natural bioactive compounds are traditional drug discovery tools, have therapeutically used dietary additives pharmaceutical agents against malignancies. The fact that natural products multiple targets minimal side effects led notable advances anticancer research. Research indicated ferroptosis also induced during treatment. In this review, we focused the most recent developments emerging molecular processes significance To provide new perspectives future development ferroptosis-related medications, summary implications phytochemicals triggering through ROS production ferritinophagy induction variety

Language: Английский

The role of ferroptosis and its mechanism in ischemic stroke DOI
Xiaodan Hu, Yutong Bao, Man Li

et al.

Experimental Neurology, Journal Year: 2023, Volume and Issue: 372, P. 114630 - 114630

Published: Dec. 4, 2023

Language: Английский

Citations

40
Pien-Tze-Huang prevents hepatocellular carcinoma by inducing ferroptosis via inhibiting SLC7A11-GSH-GPX4 axis DOI Creative Commons

Xiangying Yan,

Yudong Liu,

Congchong Li

et al.

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: June 6, 2023

Abstract Background Malignant transformation from hepatic fibrosis to carcinogenesis may be a therapeutic target for hepatocellular carcinoma (HCC). The aim of this study was evaluate anti-cancer efficacy Pien-Tze-Huang (PZH), and investigate the underlying mechanisms by integrating transcriptional regulatory network analysis experimental validation. Methods A diethylnitrosamine (DEN)-induced HCC model in rats established used PZH. After detecting transcriptomic profiling, “disease-related gene–drug effective target” interaction constructed, candidate targets PZH against malignant were identified verified vitro. Results effectively alleviated pathological changes cirrhosis, inhibited tumor formation growth DEN-induced rats. Additionally, administration reduced levels various function-related serological indicators significantly. Mechanically, ferroptosis-related SLC7A11-GSH-GPX4 axis might one potential HCC. Especially, high SLC7A11 expression associated with poor prognosis patients. Experimentally, markedly increased trivalent iron ferrous ion, suppressed GPX4 proteins, GSH/GSSG ratio liver tissues Conclusions Our data offer an evidence that improve microenvironment prevent occurrence through promoting ferroptosis cells via inhibiting axis, implying drug prevention treatment at early stage.

Language: Английский

Citations

27
Resveratrol protects against deoxynivalenol-induced ferroptosis in HepG2 cells DOI
Pengju Wang, Qing Yao,

Dan Zhu

et al.

Toxicology, Journal Year: 2023, Volume and Issue: 494, P. 153589 - 153589

Published: July 6, 2023

Language: Английский

Citations

24
Mitochondrial GPX4 acetylation is involved in cadmium-induced renal cell ferroptosis DOI Creative Commons

Yue‐Yue Guo,

Nannan Liang,

Xiaoyi Zhang

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 73, P. 103179 - 103179

Published: May 8, 2024

Increasing evidences demonstrate that environmental stressors are important inducers of acute kidney injury (AKI). This study aimed to investigate the impact exposure Cd, an stressor, on renal cell ferroptosis. Transcriptomics analyses showed arachidonic acid (ARA) metabolic pathway was disrupted in Cd-exposed mouse kidneys. Targeted metabolomics oxidized ARA metabolites were increased mice. Renal 4-HNE, MDA, and ACSL4, upregulated Consistent with animal experiments, vitro experiments mitochondrial lipids elevated HK-2 cells. Ultrastructure membrane rupture Mitochondrial cristae accordingly reduced SIRT3, NAD

Language: Английский

Citations

15
Ferroptosis and endoplasmic reticulum stress in rheumatoid arthritis DOI Creative Commons
Ao Qin, Huanhuan Hu, Ying Huang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 15, 2024

Ferroptosis is an iron-dependent mode of cell death distinct from apoptosis and necrosis. Its mechanisms mainly involve disordered iron metabolism, lipid peroxide deposition, imbalance the antioxidant system. The endoplasmic reticulum organelle responsible for protein folding, Ca

Language: Английский

Citations

12
Targeting ferroptosis in autoimmune diseases: Mechanisms and therapeutic prospects DOI

Yingzi Zheng,

Fangfang Yan, Shasha He

et al.

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 103640 - 103640

Published: Sept. 1, 2024

Language: Английский

Citations

11
Ferroptosis as a promising targeted therapy for triple negative breast cancer DOI

Kasra Mokhtarpour,

Sepideh Razi,

Nima Rezaei

et al.

Breast Cancer Research and Treatment, Journal Year: 2024, Volume and Issue: 207(3), P. 497 - 513

Published: June 14, 2024

Language: Английский

Citations

9
siRNA-mediated inhibition of hTERT enhances the effects of curcumin in promoting cell death in precursor-B acute lymphoblastic leukemia cells: an in silico and in vitro study DOI Creative Commons
Muhammad Hossein Ashoub, Ali Afgar, Alireza Farsinejad

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 24, 2025

Language: Английский

Citations

1
Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis DOI Creative Commons
Tesfahun Dessale Admasu, Kristie Kim, Michael Rae

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(2), P. 112058 - 112058

Published: Feb. 1, 2023

Senescent cells can spread the senescent phenotype to other by secreting senescence-associated secretory factors. The resulting paracrine make a significant contribution burden of cell accumulation with age. Previous efforts made characterize senescence are unreliable due analyses being based on mixed populations and non-senescent cells. Here, we use dipeptidyl peptidase-4 (DPP4) as surface maker isolate from populations. Using this technique, enrich percentage 40% 85%. We then enriched culture DPP4+ primary observe ferroptosis dysregulation ferrous iron common phenomenon in both Finally, identify induction iron-activatable prodrug broad-spectrum senolytic approach ablate multiple types

Language: Английский

Citations

22
Exploring cuproptosis as a mechanism and potential intervention target in cardiovascular diseases DOI Creative Commons
Yang Yang, Qi Feng, Ying Luan

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 11, 2023

Copper (Cu) is a vital trace element for maintaining human health. Current evidence suggests that genes responsible regulating copper influx and detoxification help preserve its homeostasis. Adequate Cu levels sustain normal cardiac blood vessel activity by mitochondrial function. Cuproptosis, unlike other forms of cell death, characterized alterations in enzymes. Therapeutics targeting cuproptosis cardiovascular diseases (CVDs) mainly include chelators, inhibitors chaperone proteins, ionophores. In this review, we expound on the primary mechanisms, critical signaling pathways involved cuproptosis, along with impact CVDs role it plays different types cells. Additionally, explored influence key regulatory proteins associated determined whether intervening metabolism can enhance outcomes CVDs. The insights from review provide fresh perspective pathogenesis new targets intervention these diseases.

Language: Английский

Citations

22