Inflammation-Induced Klotho Deficiency: A Possible Key Driver of Chronic Kidney Disease Progression DOI Creative Commons
Yan Liang, Qi Zhang, Jing Qian

et al.

International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 2507 - 2520

Published: May 1, 2025

Chronic kidney disease (CKD) is influenced by inflammation, a critical factor in its progression. However, the underlying mechanism through which inflammation contributes to CKD still obscure. The Klotho protein, predominantly found kidneys, known for protective functions, including anti-inflammatory, anti-aging, antioxidant, and anti-fibrotic effects. A myriad of studies have suggested that leads decrease expression, diminishing protection capabilities exacerbating damage, thereby promoting These findings suggest deficiency could be crucial link between regarding their relationship unclear. reduction due may attributed epigenetic mechanisms, such as DNA methylation, histone deacetylation, transcription factor, microRNA (miRNA) regulation long non-coding RNA (lncRNA) or non-epigenetic factors, endoplasmic reticulum (ER) stress ER-associated degradation (ERAD), affect protein metabolism. Through these pathways, triggers further driving Notably, also exerts strong anti-inflammatory effect inhibiting key inflammatory factors suggesting there intricate crosstalk CKD. This review highlights how suppresses expression development exacerbation By focusing on interplay Klotho, present provides novel potential therapeutic strategies correcting abnormalities treating targeting this specific axis.

Language: Английский

The Interplay Between Endoplasmic Reticulum Stress and Ferroptosis in Neurological Diseases DOI

Tianyu Zhai,

Bingbing Wang,

Caizhen Shi

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: Feb. 10, 2025

Language: Английский

Citations

1
SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2/HO-1 signaling to alleviate osteoarthritis DOI
Jiaqi Shi, Li Chen, Xu Wang

et al.

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: Feb. 10, 2025

Language: Английский

Citations

1
Iron metabolism in rheumatic diseases DOI Creative Commons

Aliakbar Givian,

Amin Azizan,

Ahmadreza Jamshidi

et al.

Journal of Translational Autoimmunity, Journal Year: 2025, Volume and Issue: 10, P. 100267 - 100267

Published: Jan. 5, 2025

Iron is a crucial element for living organism in terms of oxygen transport, hematopoiesis, enzymatic activity, mitochondrial respiratory chain function and also immune system function. The human being has evolved mechanism to regulate body iron. In some rheumatic diseases such as rheumatoid arthritis (RA), systemic lupus erythematous (SLE), sclerosis (SSc), ankylosing spondylitis (AS), gout, this balanced iron regulation impaired. Altered homeostasis can contribute disease progression through ROS production, fibrosis, inflammation, abnormal bone homeostasis, NETosis cell senescence. review, we have focused on the metabolism its role progression.

Language: Английский

Citations

0
Gastrodin Targets the System Xc-/GPX4 Axis to Inhibit Abnormal Proliferation of Fibroblast-Like Synoviocytes and Improve Rheumatoid Arthritis DOI
Yanlu Li, Jiakui Li,

Yanchao Xing

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156493 - 156493

Published: Feb. 13, 2025

Language: Английский

Citations

0
Mendelian randomization and mediation analysis reveal the role of immune cell subsets in the causal pathways between blood cell perturbation responses and rheumatoid arthritis DOI
Feng Li, Dehai Xian,

Kaiwen Yang

et al.

Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Language: Английский

Citations

0
Palmitic Acid Enhances the Sensitivity of Ferroptosis via Endoplasmic Reticulum Stress Mediated the ATF4/TXNIP Axis in Polycystic Ovary Syndrome DOI Creative Commons
Xumin Zhang, Jianrong Liu,

Chunmei Bai

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156777 - 156777

Published: April 1, 2025

Palmitic acid (PA), the most prevalent saturated fatty in humans, is closely associated with ovarian dysfunction. Elevated PA levels follicular fluid of patients polycystic ovary syndrome (PCOS) are correlated outcomes assisted reproductive technology (ART), though underlying mechanism remains unclear. Multi-omics analysis identified and TXNIP as potential pathogenic factors PCOS. CCK-8 apoptosis assay were conducted to detect cytotoxicity PA. To further investigate molecular mechanisms PA-induced ferroptosis, we established COV434 cell models both overexpression knockdown. Transmission electron microscopy (TEM), western blot (WB), ELISA assays, flow cytometry employed assess ferroptosis-related markers. A PCOS mouse model was also developed, histopathological staining, TEM, ELISA, WB performed evaluate clinical parameters related ferroptosis levels. clarify targeting relationship between ATF4 TXNIP, utilized luciferase reporter gene chromatin immunoprecipitation (ChIP), RT-qPCR for a comprehensive analysis. In vivo vitro, enhanced sensitivity ferroptosis. The protein ACSL4 upregulated after treatment. induces expression inhibitor SLC7A11 part an adaptive response. intracellular ROS levels, increased MDA content, decreased GSH/GSSG ratios, elevated ferrous iron TEM findings collectively indicated that KGN/COV434 cells. ER stress 4-PBA reduces ovaries by suppressing stress, thereby improving PCOS-like traits. Moreover, UPR regulates cellular activating transcriptional TXNIP. stimulated process mediated ATF4/TXNIP axis, which might represent progression application inhibitors improved traits reducing

Language: Английский

Citations

0
Nanodrug delivery systems targeting ferroptosis as an innovative therapeutic approach for Rheumatoid Arthritis DOI Creative Commons

Xiaolin Dai,

Yu‐Jun Zheng,

J. J. Cui

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101804 - 101804

Published: April 25, 2025

Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by joint inflammation, progressive cartilage degradation, and bone erosion. Recent research has implicated ferroptosis not only in autoimmune hepatitis but also the pathogenesis progression of disorders like RA. Consequently, numerous therapeutic strategies have begun to target pathway, particularly design development nanodrug delivery systems (NDDSs). While previous reviews comprehensively discussed mechanisms ferroptosis, related signaling pathways, NDDS materials, recent studies further elucidated interplay between various metabolic providing robust theoretical basis for NDDS-based strategies. This review focuses on investigating role RA, aiming elucidate how targeting can offer novel concepts potential treatments RA patients. Specifically, it summarizes ferroptosis-based NDDSs via different pathways highlights feasibility treatment regimens based mechanism. Furthermore, critically discusses current limitations offers perspectives future directions this field.

Language: Английский

Citations

0
Crosstalk between ferroptosis and endoplasmic reticulum stress: A potential target for ovarian cancer therapy (Review) DOI
Jiaqi Yang, Yu Wang, Fang-Yuan Liu

et al.

International Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: 55(6), P. 1 - 20

Published: April 28, 2025

Ferroptosis is a unique mode of cell death driven by iron‑dependent phospholipid peroxidation, and its mechanism primarily involves disturbances in iron metabolism, imbalances the lipid antioxidant system accumulation peroxides. Protein processing, modification folding endoplasmic reticulum (ER) are closely related regulatory processes that determine function, fate survival. The uncontrolled proliferative capacity malignant cells generates an unfavorable microenvironment characterized high metabolic demand, hypoxia, nutrient deprivation acidosis, which promotes misfolded or unfolded proteins ER, leading to ER stress (ERS). ERS share common pathways several diseases, two interact affect survival death. Additionally, not linear signaling cascades, different may be interrelated at multiple levels. ovarian cancer (OC) have attracted increasing research interest; however, both discussed separately regarding OC. present review aims summarize associations potential links between ferroptosis ERS, aiming provide references for development therapeutic approaches management

Language: Английский

Citations

0
Computational investigation of the interplay between cellular stress and ferroptosis in triple-negative breast cancer DOI

Donia G Youssef,

Hamdy I A Mostafa,

Ahmed Hassan Ibrahim Faraag

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 271, P. 156008 - 156008

Published: May 13, 2025

Language: Английский

Citations

0
Immunometabolic shifts in autoimmune disease: Mechanisms and pathophysiological implications DOI
Yue Chen, Qingqing Lin, Hui Cheng

et al.

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: 24(3), P. 103738 - 103738

Published: Dec. 30, 2024

Language: Английский

Citations

3