Social and circadian rhythm dysregulation and suicide: A systematic review and meta-analysis

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 158, P. 105560 - 105560

Published: Jan. 23, 2024

Language: Английский

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Therapeutic Effects of Melatonin in the Regulation of Ferroptosis: A Review of Current Evidence

Current Drug Targets, Journal Year: 2024, Volume and Issue: 25(8), P. 543 - 557

Published: May 6, 2024

Ferroptosis is implicated in the pathogenesis of multiple diseases, including neurodegenerative cardiovascular kidney pathologies, ischemia-reperfusion injury, and cancer. The current review article highlights involvement ferroptosis traumatic brain acute damage, ethanol-induced liver PM2.5-induced lung injury. Melatonin, a molecule produced by pineal gland many other organs, well known for its anti- aging, anti-inflammatory, anticancer properties used treatment different diseases. Melatonin's ability to activate anti-ferroptosis pathways sirtuin (SIRT)6/p- nuclear factor erythroid 2-related 2 (Nrf2), Nrf2/ antioxidant responsive element (ARE)/ heme oxygenase (HO-1)/SLC7A11/glutathione peroxidase (GPX4)/ prostaglandin-endoperoxide synthase (PTGS2), extracellular signal-regulated kinase (ERK)/Nrf2, ferroportin (FPN), Hippo/ Yes-associated protein (YAP), Phosphoinositide 3-kinase (PI3K)/ B (AKT)/ mammalian target rapamycin (mTOR) SIRT6/ receptor coactivator 4 (NCOA4)/ ferritin heavy chain 1 (FTH1) signaling suggests that it could serve as valuable therapeutic agent preventing cell death associated with various Further research needed fully understand precise mechanisms which melatonin regulates potential target.

Language: Английский

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Critical illness-based chronic disease: a new framework for intensive metabolic support

Current Opinion in Critical Care, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

This review addresses the novel concept of critical illness as a potential chronic disease. The high clinical and economic burdens post-ICU syndromes are mainly due to refractoriness therapy consequently lead significant complications. Interventions need be preventive in nature therefore robust disease model is warranted. There three paradigms that leveraged create new illness-based (CIBCD) model: metabolic illness, intensive support (IMS; insulinization nutrition support), driver-based modeling. CIBCD consists four stages: risk, predisease, (chronic) disease, principal goal expose early opportunities prevent progression, particularly further morbidity, complications, mortality. IMS used target seminal pathophysiological events such immune-neuroendocrine axis (INA) activation failure downregulate INA because preexisting diseases recurrent pathological insults. complements our understanding provides needed structure actions can improve outcomes. Many research, knowledge, practice gaps exist, which will addressed optimize validate this model.

Language: Английский

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The Influence of Weather Conditions on the Diurnal Variation in Range of Motion in Older Adults with Knee Osteoarthritis

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(1), P. 254 - 254

Published: Jan. 1, 2024

(1) Background: This study investigated the relationship between weather conditions, diurnal patterns, and total knee range of motion (ROM), as well severity symptoms (pain stiffness) in older adults with osteoarthritis. (2) Methods: An exploratory longitudinal was conducted on 28 osteoarthritis (mean age 71.86 ± 4.49 years; 46.4% men, 53.6% women). We used assessment tools Visual Analog Scales (VAS) for self-reported local pain stiffness, goniometry ROM. Measurements were taken twice, six months apart, winter summer, morning evening each selected day. Recorded factors comprised temperature, relative humidity, barometric pressure, maximum wind speed. (3) Results: The revealed significant effects season time day respectively (p < 0.001). Additionally, a interaction influenced ROM Moreover, there statistically (4) Conclusions: research underscores complex link seasonal fluctuations daily variations some symptomatic functional aspects adults.

Language: Английский

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Impact of Prenatal LPS and Early-life Constant Light Exposure on Circadian Gene Expression Profiles in Various Rat Tissues

Neuroscience, Journal Year: 2024, Volume and Issue: 551, P. 17 - 30

Published: May 20, 2024

Language: Английский

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Light, sleep and circadian rhythm in critical illness

Current Opinion in Critical Care, Journal Year: 2024, Volume and Issue: 30(4), P. 283 - 289

Published: May 28, 2024

Purpose of review Sleep and circadian disruption (SCD) are associated with worse outcomes in the ICU population. We discuss sleep, physiology, role light entrainment its possible treating SCD, special attention to use therapies design. Recent findings The American Thoracic Society recently published an official research statement highlighting key areas required define treat SCD. literature has been predominantly observational, describing how both critical illness environment might impair normal sleep impact rhythm. Emerging consensus guidance outlines need for standardized metrics clinical trials investigating effects therapies. A recent proof-of-concept randomized controlled trial (RCT) showed improvement delirium incidence alignment from room redesign that included a dynamic lighting system (DLS). Summary Further investigation is needed optimal physical properties therapy as well timing duration treatments. Work this area will inform future circadian-promoting design, multicomponent nonpharmacological protocols, mitigate SCD objective improving patient outcomes.

Language: Английский

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Scandinavian healthcare professionals’ perceptions of rehabilitation practices in the intensive care unit. A cross-sectional survey

Intensive and Critical Care Nursing, Journal Year: 2024, Volume and Issue: unknown, P. 103842 - 103842

Published: Oct. 1, 2024

To describe healthcare professionals' perception of current early rehabilitation practices and their preconditions, focusing on functional cognitive stimulation facilitated by nurses other professionals in Scandinavian intensive care units (ICUs).

Language: Английский

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The negative effect on human health due to disruption of circadian rhythm in modern times

Medical Journal of Cell Biology, Journal Year: 2024, Volume and Issue: 12(1), P. 21 - 25

Published: July 1, 2024

Abstract Disruptions of the circadian rhythm have shown that it can lead to significant health risks. Factors such as rapid travel across different time zones, increased exposure artificial light, and consumption substances like caffeine contribute this disruption. Understanding these disruptions its causes is crucial for improving our in finding solutions.

Language: Английский

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Patient Care: From Body to Mind

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 33 - 47

Published: Jan. 1, 2024

Language: Английский

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Preface on highlights in anesthesia and critical care medicine

Annals of Translational Medicine, Journal Year: 2023, Volume and Issue: 12(1), P. 1 - 1

Published: Dec. 14, 2023

Language: Английский

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