Recent developments in physical, biological, chemical, and hybrid treatment techniques for removing emerging contaminants from wastewater

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 416, P. 125912 - 125912

Published: April 23, 2021

Language: Английский

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Endocrine-Disrupting Chemicals and Disease Endpoints

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5342 - 5342

Published: March 10, 2023

Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, and been shown to interfere with physiological especially by disrupting the hormone balance. During last few decades, EDCs affect reproductive, neurological, metabolic development function even stimulate tumor growth. EDC exposure during can disrupt normal patterns alter susceptibility disease. Many endocrine-disrupting properties, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, phthalates. These compounds gradually elucidated as risk factors for many diseases, such neural, diseases cancers. Endocrine disruption has spread wildlife species that are connected food chains. Dietary uptake represents an important source of exposure. Although represent a public health concern, relationship specific mechanism between remain unclear. This review focuses disease-EDC disease endpoints associated endocrine better understanding EDCs-disease elucidates new prevention/treatment opportunities screening methods.

Language: Английский

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Establishing the Mechanisms Involved in the Environmental Exposure to Polychlorinated Biphenyls (PCBs) in the Risk of Male Infertility

Reproductive Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

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Fetal–Maternal Exposure to Endocrine Disruptors: Correlation with Diet Intake and Pregnancy Outcomes

Nutrients, Journal Year: 2020, Volume and Issue: 12(6), P. 1744 - 1744

Published: June 11, 2020

Endocrine-disrupting chemicals (EDCs) are exogenous substances able to mimic or interfere with the endocrine system, thus altering key biological processes such as organ development, reproduction, immunity, metabolism and behavior. High concentrations of EDCs found in several everyday products including plastic bottles food containers they could be easily absorbed by dietary intake. In recent years, considerable interest has been raised regarding effects EDCs, particularly Bisphenol A (BPA) phthalates, on human pregnancy fetal development. Several evidence obtained vitro animal models well epidemiologic population studies strongly indicated that disruptors negatively impact placental health interfering embryonic developing epigenome, establishing disease paths into adulthood. Moreover, cause and/or contribute onset severe gestational conditions Preeclampsia (PE), Fetal Growth Restriction (FGR) diabetes pregnancy, obesity, cardiovascular complications reproductive age. Therefore, despite contrasting data being present literature, must considered a therapeutic target. Future actions aimed at reducing eliminating EDC exposure during perinatal period mandatory guarantee success preserve adult health.

Language: Английский

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Impact of environmental toxin exposure on male fertility potential

Translational Andrology and Urology, Journal Year: 2020, Volume and Issue: 9(6), P. 2797 - 2813

Published: Dec. 1, 2020

Idiopathic infertility is the most common individual diagnosis in male infertility, representing nearly 44% of cases. Research studies dating over last half-century consistently demonstrate a decline fertility that incompletely explained by obesity, known genetic causes, or diet and lifestyle changes alone. Human exposures have changed dramatically same time course as this decline. Synthetic chemicals surround us. Some are benevolent; however, many to cause disruption hypothalamic-pituitary-gonadal axis impair spermatogenesis. More than 80,000 registered with United States National Toxicology Program 2,000 new introduced each year. Many these toxins, such phthalates, polycyclic aromatic hydrocarbons, amines, organophosphate esters, been banned significantly restricted other countries they carry carcinogenic effects reproductively toxic. In States, still permissible exposure levels reproductive harm. This contrasts chemical regulatory legislature, European Union's REACH (Registration, Evaluation, Authorization Restriction Chemicals) regulations which more comprehensive restrictive. Quantification diverse on an level has proven challenging, although forthcoming technologies may soon make data available consumers. Establishing causality proportion idiopathic attributable environmental toxin remains elusive, continued investigation, avoidance exposure, mitigation risk essential our health. The aim review examine literature linking some exposures. Specifically, pesticides herbicides dichlorodiphenyltrichloroethane (DDT), dibromochloropropane (DBCP), organophosphates atrazine, endocrine disrupting compounds including plastic phthalates bisphenol A (BPA), heavy metals, natural gas/oil, non-ionizing radiation, air noise pollution, factors diet, caffeine use, smoking, alcohol drug well commonly prescribed medications will be discussed.

Language: Английский

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Environmental contaminants and male infertility: Effects and mechanisms

Andrologia, Journal Year: 2020, Volume and Issue: 53(1)

Published: May 24, 2020

The escalating prevalence of male infertility and decreasing trend in sperm quality have been correlated with rapid industrialisation the associated discharge an excess synthetic substances into environment. Humans are inevitably exposed to these ubiquitously distributed environmental contaminants, which possess ability intervene growth function reproductive organs. Several epidemiological reports blood seminal levels contaminants poor quality. Numerous vivo vitro studies conducted investigate effect various on spermatogenesis, steroidogenesis, Sertoli cells, blood-testis barrier, epididymis functions. reported reprotoxic effects include alterations spermatogenic cycle, increased germ cell apoptosis, inhibition decreased Leydig viability, impairment structure function, altered expression steroid receptors, permeability induction peroxidative epigenetic spermatozoa resulting function. In light recent scientific reports, this review discusses possible mechanisms action.

Language: Английский

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Emerging pollutants in Nigeria: A systematic review

Environmental Toxicology and Pharmacology, Journal Year: 2021, Volume and Issue: 85, P. 103638 - 103638

Published: March 20, 2021

Language: Английский

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Insights Into the Prevalence and Impacts of Phthalate Esters in Aquatic Ecosystems

Frontiers in Environmental Science, Journal Year: 2021, Volume and Issue: 9

Published: July 15, 2021

Phthalate esters (PEs) are by far the most produced and extensively used synthetic organic chemicals with notable applications in many industrial products such as vinyl upholstery, adhesives, food containers, packaging materials, printing inks, cosmetics, paints, pharmaceuticals munitions, insecticides among other. PEs have long been recognised ubiquitous pollutants of prime environmental concern, urbanisation amongst main cause source these compounds. Due to their notoriety, compounds known pose devastating effects living organisms including humans. The presence metabolites aquatic ecosystems is concern primarily due endocrine disrupting carcinogenicity properties. Several research studies reported prevalence, exposure pathways, toxicity, impacts Their principal routes could be direct or indirect, which route include contact, eating, drinking contaminated foods, indirect constitute aerosols, leaching other forms contamination. find way into water systems through means effluent discharges, urban agricultural land runoff, from waste dumps diffuse sources. High-end instrumentation improved methodologies on hand resulted increased ability measure trace levels (μg/L) different matrices ecological compartments lakes, oceans, rivers, sediments, wetlands samples. In light above, this article provides an informed focused information prevalence phthalate related Furthermore, techniques that enabled extraction analysis samples also explained. Future outlooks needs highlighted manuscript. This will better understand temporal spatial distributions aid devising prudent curtail footprints.

Language: Английский

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An innovative approach of bioremediation in enzymatic degradation of xenobiotics

Biotechnology and Genetic Engineering Reviews, Journal Year: 2022, Volume and Issue: 38(1), P. 1 - 32

Published: Jan. 2, 2022

Worldwide, environmental pollution due to a complex mixture of xenobiotics has become serious concern. Several xenobiotic compounds cause contamination their severe toxicity, prolonged exposure, and limited biodegradability. From the past few decades, microbial-assisted degradation (bioremediation) pollutants evolved as most effective, eco-friendly, valuable approach. Microorganisms have unique metabolism, capability genetic modification, diversity enzymes, various pathways necessary for bioremediation process. Microbial is effective but slow process that limits its application in bioremediation. However, study microbial enzymes gaining global importance. huge ability transform contaminants into non-toxic forms thereby reduce pollution. Recently, advanced techniques, including metagenomics, proteomics, transcriptomics, metabolomics are effectively utilized characterization, metabolic machinery, new proteins, genes microorganisms involved These molecular techniques provide thorough understanding structural functional aspects microorganisms. This review gives brief note on impact environment. Particular attention will be devoted class such cytochrome P450, dehydrogenase, laccase, hydrolase, protease, lipase, etc. capable converting these innocuous products. attempts deliver knowledge role biodegradation pollutants, along with use technologies like recombinant DNA technology Omics approaches make more robust effective.

Language: Английский

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Triclosan: A Small Molecule with Controversial Roles

Antibiotics, Journal Year: 2022, Volume and Issue: 11(6), P. 735 - 735

Published: May 30, 2022

Triclosan (TCS), a broad-spectrum antimicrobial agent, has been widely used in personal care products, medical plastic cutting boards, and food storage containers. Colgate Total® toothpaste, containing 10 mM TCS, is effective controlling biofilm formation maintaining gingival health. Given its broad usage, TCS present ubiquitously the environment. strong lipophilicity accumulation ability organisms, it potentially harmful to biohealth. Several reports suggest toxicity of this compound, which inserted class endocrine disrupting chemicals (EDCs). In September 2016, was banned by U.S. Food Drug Administration (FDA) European Union soap products. Despite these problems, application products within certain limits still allowed. Today, unclear whether truly toxic mammals adverse effects continuous, long-term, low concentration exposure remain unknown. Indeed, some recent use as repositioned drug for cancer treatment cutaneous leishmaniasis. scenario necessary investigate advantages disadvantages understand advisable or not. This review intends highlight pros cons that are associated with humans.

Language: Английский

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