International Journal of Environmental Research and Public Health,
Journal Year:
2021,
Volume and Issue:
18(13), P. 6846 - 6846
Published: June 25, 2021
Several
studies
indicate
that
semen
quality
has
strongly
declined
in
the
last
decades
worldwide.
Air
pollution
represents
a
significant
co-factor
with
COVID-19
impact
and
negative
effects
on
male
reproductive
system,
through
pro-oxidant,
inflammatory
immune-dysregulating
mechanisms.
It
recently
been
reported
chronic
exposure
to
PM2.5
causes
overexpression
of
alveolar
ACE2
receptor,
entry
route
SARS-CoV-2
into
organism
shared
by
lungs
testis
where
expression
is
highest
body.
In
testis,
ACE2/Ang-(1–7)/MasR
pathway
plays
an
important
role
regulation
spermatogenesis
indirect
mechanism
testicular
damage
could
be
due
blockade
receptor
SARS-CoV-2.
This
prevents
conversion
specific
angiotensins,
their
excess
inflammation
overproduction
cytokines.
PM2.5-induced
turn,
increase
local
viral
load
patients
exposed
pollutants,
producing
depletion
compromising
host
defenses.
By
presenting
overall
view
epidemiological
data
molecular
mechanisms,
this
manuscript
aims
interpret
possible
synergistic
both
air
function,
warning
spread
fertile
years
may
represent
threat
global
health.
All
should
great
concern,
especially
for
men
age
maximum
capacity,
topic
debate
policy
makers.
Altered
environmental
conditions,
together
direct
short-
long-term
infection
cause
worsening
consequences
fertility,
those
areas
higher
impact.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1556 - 1556
Published: May 21, 2024
During
the
last
decades,
endocrine-disrupting
chemicals
(EDCs)
have
attracted
attention
of
scientific
community,
as
a
result
deepened
understanding
their
effects
on
human
health.
These
compounds,
which
can
reach
populations
through
food
chain
and
number
daily
life
products,
are
known
to
modify
activity
endocrine
system.
Regarding
vulnerable
groups
like
pregnant
mothers,
potential
damage
they
cause
increases
importance,
since
it
is
health
two
lives
that
at
risk.
EDCs
affect
gestation
process,
altering
fetal
development,
eventually
inducing
appearance
many
disorders
in
childhood
and/or
adulthood.
Because
this,
several
these
substances
been
studied
clarify
influence
prenatal
exposure
cognitive
psychomotor
development
newborn,
together
with
non-communicable
diseases
other
disorders.
The
most
novel
research
subject
has
gathered
this
narrative
review,
aim
clarifying
current
knowledge
subject.
shown,
different
studies
involving
both
animal
investigation,
detrimental
effect
children
exposed
during
pregnancy,
sometimes
sex-specific
outcomes.
However,
some
failed
find
associations,
highlights
need
for
deeper
more
rigorous
research,
will
provide
an
even
solid
foundation
establishment
policies
against
extended
use
chemicals.
American Journal of Biomedical Science & Research,
Journal Year:
2019,
Volume and Issue:
4(5), P. 332 - 337
Published: Aug. 20, 2019
Personal
care
products
and
facial
cosmetics
are
commonly
used
by
millions
of
consumers
on
a
daily
basis.
Direct
application
human
skin
makes
it
vulnerable
to
wide
variety
ingredients.
Despite
the
protecting
role
against
exogenous
contaminants,
some
ingredients
in
cosmetic
able
penetrate
produce
systemic
exposure.
Consumers'
knowledge
potential
risks
frequent
should
be
improved.
While
regulations
exist
most
high-income
countries,
low
income
countries
there
is
lack
similar
standards.
In
for
which
these
legal
have
been
identified,
restrictions
permissible
level
heavy
metals
strict.
There
need
enforcement
existing
rules,
rigorous
assessment
effectiveness
regulations.
The
occurrence
concern
three
principal
reasons:
International Journal of Environmental Research and Public Health,
Journal Year:
2021,
Volume and Issue:
18(13), P. 6846 - 6846
Published: June 25, 2021
Several
studies
indicate
that
semen
quality
has
strongly
declined
in
the
last
decades
worldwide.
Air
pollution
represents
a
significant
co-factor
with
COVID-19
impact
and
negative
effects
on
male
reproductive
system,
through
pro-oxidant,
inflammatory
immune-dysregulating
mechanisms.
It
recently
been
reported
chronic
exposure
to
PM2.5
causes
overexpression
of
alveolar
ACE2
receptor,
entry
route
SARS-CoV-2
into
organism
shared
by
lungs
testis
where
expression
is
highest
body.
In
testis,
ACE2/Ang-(1–7)/MasR
pathway
plays
an
important
role
regulation
spermatogenesis
indirect
mechanism
testicular
damage
could
be
due
blockade
receptor
SARS-CoV-2.
This
prevents
conversion
specific
angiotensins,
their
excess
inflammation
overproduction
cytokines.
PM2.5-induced
turn,
increase
local
viral
load
patients
exposed
pollutants,
producing
depletion
compromising
host
defenses.
By
presenting
overall
view
epidemiological
data
molecular
mechanisms,
this
manuscript
aims
interpret
possible
synergistic
both
air
function,
warning
spread
fertile
years
may
represent
threat
global
health.
All
should
great
concern,
especially
for
men
age
maximum
capacity,
topic
debate
policy
makers.
Altered
environmental
conditions,
together
direct
short-
long-term
infection
cause
worsening
consequences
fertility,
those
areas
higher
impact.
