Susceptibility of SARS Coronavirus-2 infection in domestic and wild animals: a systematic review

3 Biotech, Journal Year: 2022, Volume and Issue: 13(1)

Published: Dec. 11, 2022

Language: Английский

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Dynamics of simultaneous propagation of two COVID-19 strains

Advances in Continuous and Discrete Models, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Feb. 10, 2025

In this work, we present a mathematical framework that captures the dynamic behavior of simultaneous propagation two strains COVID-19. We apply next-generation matrix method to compute basic reproduction ratio $\mathscr{R}_{0}$ . investigate stability model at each feasible equilibria. To validate our theoretical results, have conducted numerical simulations. It is observed if $\mathscr{R}_{0} \leq 1$ , eventually there will be no disease. However, > competition between COVID-19 occur, and more infectious variant survive while other disappears.

Language: Английский

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On the Dynamics of COVID-19 Propagation with Vaccination and Optimal Control Strategies

Brazilian Journal of Physics, Journal Year: 2025, Volume and Issue: 55(3)

Published: April 15, 2025

Language: Английский

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SARS-CoV-2 Droplet and Airborne Transmission Heterogeneity

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(9), P. 2607 - 2607

Published: May 6, 2022

The spread dynamics of the SARS-CoV-2 virus have not yet been fully understood after two years pandemic. virus’s global represented a unique scenario for advancing infectious disease research. Consequently, mechanistic epidemiological theories were quickly dismissed, and more attention was paid to other approaches that considered heterogeneity in spread. One most critical advances aerial pathogens transmission acceptance airborne model, where airway is presented as epicenter disease. Although aerodynamics persistence air extensively studied, actual probability contagion still unknown. In this work, individual 22 patients infected with COVID-19 analyzed by close contact (cough samples) (environmental samples). Viral RNA detected 2/19 cough samples from patient subgroups, mean Ct (Cycle Threshold Quantitative Polymerase Chain Reaction analysis) 25.7 ± 7.0. Nevertheless, viral only 1/8 patients, an average 25.0 4.0. load ranged 7.3 × 105 8.7 108 copies/mL among while concentrations between 1.1–4.8 copies/m3 found air, consistent reports literature. undergoing follow-up, no (neither coughs nor air) third day symptoms, which could help define quarantine periods individuals. addition, it patient’s should be indicator infectiousness, since correlated disseminated. results work are line proposed hypotheses superspreaders, can attribute part oversized emission small percentage people.

Language: Английский

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The Origins of Severe Acute Respiratory Syndrome-Coronavirus-2

Seminars in Respiratory and Critical Care Medicine, Journal Year: 2023, Volume and Issue: 44(01), P. 003 - 007

Published: Jan. 16, 2023

An outbreak of severe pneumonia unknown cause was identified in Wuhan, China December 2019: the causative agent a novel betacoronavirus, acute respiratory syndrome-cotonavirus-2 (SARS-CoV-2), virus that joins list coronaviruses causing (e.g., SARS and Middle East syndrome) or milder 229E, OC43, NL63, HKU1) tract infection. The World Health Organization (WHO) classified spreading as pandemic on March 11, 2020. Many SARS-related (SARSr-CoVs) have been bats, particularly Rhinolophus horseshoe animals are common southern Southeast Asia. features SARS-CoV-2 facilitate human infection-the furin cleavage site, receptor binding domain binds to ACE2 receptor-can be SARSr-CoVs. Related can detected pangolins other animals, itself infect various some which transmit back humans. Investigation by WHO others pointed initial being centered Huanan wet market Wuhan where wild farmed were sold, environmental testing revealed widespread contamination. This supports hypothesis probably via an intermediate animal, origin SARS-CoV-2. Other possible origins postulated, such accidental deliberate laboratory leak, present frozen foods, but evidence for these ideas has not surfaced. Study complicated intense media political commentary, may slow studies required understand viral origins. Such complex slow: international openness co-operation is vital. Origins explanations needed predict prevent future pandemics support "One Health" approach disease.

Language: Английский

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Diversity and prevalence of zoonotic infections at the animal-human interface of primate trafficking in Peru

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(2), P. e0287893 - e0287893

Published: Feb. 7, 2024

Wildlife trafficking creates favorable scenarios for intra- and inter-specific interactions that can lead to parasite spread disease emergence. Among the fauna affected by this activity, primates are relevant due their potential acquire share zoonoses - infections caused parasites between humans other animals. Though it is known most primate affect multiple hosts many zoonotic, comparative studies across different contexts animal-human scarce. We conducted a multi-parasite screening targeting detection of zoonotic in wild-caught monkeys nine Peruvian cities three contexts: captivity (zoos rescue centers, n = 187); pet (households, 69); trade (trafficked or recently confiscated, 132). detected 32 taxa including mycobacteria, simian foamyvirus, bacteria, helminths, protozoa. Monkeys context had highest prevalence hemoparasites (including Plasmodium malariae/brasilianum , Trypanosoma cruzi microfilaria) enteric helminths protozoa were less common monkeys. However, communities showed overall low variation contexts. Parasite richness (PR) was best explained host genus city where animal sampled. Squirrel (genus Saimiri ) wooly Lagothrix PR, which ~2.2 times PR found tufted capuchins Sapajus tamarins Saguinus/Leontocebus multivariable model adjusted context, sex, age. Our findings illustrate threats wildlife One Health encompass exposure well-known cause humans, monkeys, species. demonstrate these continue beyond markets initially sold; trafficked market remain reservoir contribute translocation households captive facilities contact with frequent. results have practical applications healthcare rescued call urgent action against ownership as pets.

Language: Английский

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Association between SARS-CoV-2 and metagenomic content of samples from the Huanan Seafood Market

Virus Evolution, Journal Year: 2023, Volume and Issue: 9(2)

Published: July 1, 2023

Abstract The role of the Huanan Seafood Market in early severe acute respiratory syndrome virus 2 (SARS-CoV-2) outbreak remains unclear. Recently, Chinese Centers for Disease Control (CDC) released data from deep sequencing environmental samples collected market after it was closed on 1 January 2020. Prior to this release, Crits-Christoph et al. analyzed a subset samples. Both that study and CDC concurred contained genetic material variety species, including some like raccoon dogs are susceptible SARS-CoV-2. However, neither systematically relationship between amount SARS-CoV-2 different animal species. Here I implement fully reproducible computational pipeline jointly analyzes number reads mapping mitochondrial genomes chordate species across full set validate presence numerous calculate mammalian compositions similar those reported by content is generally very low: only 21 176 contain more than ten reads, despite most being sequenced depths exceeding 108 total reads. None with double-digit numbers have substantial fraction their any non-human Only one fourteen at least fifth contains sample has ~200,000,000 Instead, correlated various fish, such as catfish largemouth bass. These results suggest while metagenomic analysis useful identifying animals or products sold market, co-mingling viral unlikely reliably indicate whether were infected

Language: Английский

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SARS-CoV-2 infection at the Huanan seafood market

Environmental Research, Journal Year: 2022, Volume and Issue: 214, P. 113702 - 113702

Published: June 22, 2022

The Huanan market harbored many of the early COVID-19 cases in 2019 and is a key element to understanding origin pandemic. Whether initial animal-to-human transmission did occur at this still debated. Here we do not examine how SARS-CoV-2 virus was introduced market, but focus on may have been infected market. Based available evidence, suggest that several infections occurred via human-to-human closed spaces such as canteens, Mahjong rooms or toilets. We advocate for further studies investigate hypothesis.

Language: Английский

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Perceptions of COVID-19 origins and China’s wildlife policy reforms

Global Ecology and Conservation, Journal Year: 2023, Volume and Issue: 43, P. e02463 - e02463

Published: April 6, 2023

Given the link between perceptions of zoonotic risk and support for regulations such as wildlife consumption bans, debates regarding origins COVID-19 are likely to have conservation implications. Specifically, alternative hypotheses that cast doubt on COVID-19's could potentially lessen momentum China's policy reforms their associated impacts. To better understand impact origin policies, we conducted a 974-respondent survey across mainland China, supplemented by media reviews. We examined three facets origins: geographic location, source (e.g., farm, wet market, etc.), specific species transmitters. Our findings reveal 64.6 % respondents believed originated in United States or Europe, not China. Further, compared baseline group who selected China country, Europe had greater likelihood selecting laboratories/research imported frozen foods sources, while these lower wild animals market natural causes sources. Despite varied beliefs origins, was strong: 89.5 previously consumed self-indicated reduced after pandemic 70.5 supported banning trade all species. Moreover, those supporting ban wild-caught farmed wildlife. results indicate that, although investigation is on-going politicized, there clear can promote outcomes.

Language: Английский

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COVID-origins data from Wuhan market published: what scientists think

Nature, Journal Year: 2023, Volume and Issue: 616(7956), P. 225 - 226

Published: April 5, 2023

Language: Английский

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