Selective Blood Cell Hitchhiking in Whole Blood with Ionic Liquid-Coated PLGA Nanoparticles to Redirect Biodistribution After Intravenous Injection

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: July 11, 2023

Abstract Less than 5% of intravenously-injected nanoparticles (NPs) reach destined sites in the body due to opsonization and immune-based clearance vascular circulation. By hitchhiking situ onto specific blood components post-injection, NPs can selectively target tissue for unprecedentedly high drug delivery rates . Choline carboxylate ionic liquids (ILs) are biocompatible liquid salts <100℃ composed bulky asymmetric cations anions. This class ILs has been previously shown significantly extend circulation time redirect biodistribution BALB/c mice post-IV injection via on red cell (RBC) membranes. Herein, we synthesized & screened 60 choline carboxylic acid-based coat PLGA present impact structurally engineering coordinated anion identity interface hitchhike lymphocytes, monocytes, granulocytes, platelets, RBCs whole mouse targeted delivery. Furthermore, find this nanoparticle platform be (non-cytotoxic), translate human by resisting serum uptake maintaining modest hitchhiking, also retention over 24 hours healthy adult after IV injection. Because their altered profiles, additionally observe dramatically different organ accumulation profiles compared bare NPs. study establishes an initial breakthrough a modular transformative targeting technology with efficacy safety bloodstream administration.

Language: Английский

Ionic liquids and their potential use in development and improvement of drug delivery systems: evidence of their tendency to promote drug accumulation in the brain.

Pharmaceutical Development and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Oct. 15, 2024

Ionic liquids (ILs) are considered salt in liquid state, which is composed of organic cations and anions with low melting points (<100 °C). ILs have become a major scientific area an extensive range applications including chemistry, electrochemistry, pharmaceutics. received great research interest the pharmaceutical field as solvents, anti-solvents, co-solvents, reagents synthesis formulation. While therapeutic been investigated for oral trans-dermal drug delivery systems showing promising compatibility wide therapeutics, enhanced permeation through skin, cell membrane solvation to open channels facilitate molecular passage, their potential cross challenging blood-brain barrier (BBB) remains unanswered question. IL-based therapies could potentially be game changer improving cellular targets both at across BBB. In this review, we discuss (1) tunable physicochemical properties ILs; (2) vast various development improvement systems; (3) approach increasing accumulation brain tissue.

Language: Английский