Serologic evolution and follow-up to IgG antibodies of infants born to mothers with gestational COVID

BMC Pregnancy and Childbirth, Journal Year: 2023, Volume and Issue: 23(1)

Published: Aug. 30, 2023

It is known that SARS-CoV-2 antibodies from pregnant women with infection during pregnancy cross the placenta but duration and protective effect of these in infants scarce.This prospective study included mothers SARS-COV-2 their April 2020 to March 2021. IgG spike protein were performed on at birth two six months follow-up. Anthropometrical measures physical neurological examinations a clinical history symptoms COVID-19 diagnosis collected. Simple linear regression was compare categorical continuous variables. To mother's infant's antibody titers evolution, mixed model used. A predictive newborn has been established by means simple stepwise regression.51 mother-infant couples included. 45 (90%) 44 (86.3%) newborns had positive serology al birth. These progressively decreasing 34 (66.7%) 7 (13.7%) 2 6 months, respectively. related mothers' titers, moderate correlation (Pearson's coefficient: 0.82, p < 0,001). Fetal/maternal placental transference rate 1.3 (IQR: 0.7-2.2). The maternal delivery type (acute, recent, or past infection) significantly infants' No other epidemiological factors titers. Neurodevelopment, psychomotor development, growth normal 94.2% third follow-up visit. period.Transplacental transfer high recent delivery, decrease after first life. Infant's delivery. Further studies are needed learn about role infants.

Language: Английский

Do Anti-SARS-CoV-2 Monoclonal Antibodies Have an Impact on Pregnancy Outcome? A Systematic Review and Meta-Analysis

Vaccines, Journal Year: 2023, Volume and Issue: 11(2), P. 344 - 344

Published: Feb. 3, 2023

Monoclonal antibodies (mAbs) have been used as a rescue strategy for pregnant women affected by COVID-19. To explore its impact on maternal-fetal health, we included all observational studies reporting maternal, fetal, delivery and neonatal outcomes in who underwent mAbs infusion Primary outcome was the percentage of preterm delivery. We meta-analyses proportions to combine data treated with COVID-19 reported pooled their 95% confidence intervals (CIs) categorical variables or mean difference (MD) continuous variables. Preterm birth observed 22.8% cases (95% CI 12.9–34.3). Fetal distress 4.2% 1.6–8.2). Gestational hypertension pre-eclampsia were 3.0% 0.8–6.8) 3.4% 0.8–7.5) cases, respectively. growth restriction 3.2% fetuses 0.8–7.0). Secondary prophylaxis is currently considered best treatment option people mild moderate disease. More attention should be paid infants born from mothers mAbs, risk immunosuppression.

Language: Английский

Impact of COVID-19 on Breastfeeding among SARS-CoV-2 Infected Pregnant Women: A Single Centre Survey Study

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 20(1), P. 228 - 228

Published: Dec. 23, 2022

Background: Although current guidelines recommend that mothers with suspected or confirmed SARS-CoV-2 infection should be encouraged to initiate and continue breastfeeding, up-to-date literature shows conflicting data regarding breastfeeding experiences in infected women. This survey aimed report on the psychological impact of practice medical counselling a single tertiary center Southern Italy. Methods: One-hundred women at delivery were given an anonymous questionnaire women’s perception COVID-19 breastfeeding. Results: 75% reported they had difficulty breastfeeding; among them, 66 (66%) declared separation from their babies after affected ability breastfeed. Incidence difficulties was higher who underwent caesarean section compared vaginal (56/65, 86.2% vs. 19/35, 54.3%, χ2 = 12.322, p < 0.001) hospital stay more than 5 days (48/57, 84.2% 23/37, 62.2%, 5.902, 0.015). Furthermore, incidence subsequently decided use exclusively infant formula mixed maternal milk breastfed (48/49, 98% 20/25, 80% 7/26, 26.9%, 46.160, 0.001). Conclusions: Our highlights importance healthcare support information hygiene practices decrease perceived stress related for under restrictions, especially undergoing cesarean long stay.

Language: Английский