Camote de pulpa morada (Ipomoea batatas L.) y sus antocianinas: de postre tradicional a fuente de colorante natural DOI
Luz Araceli Ochoa‐Martínez, Sandra Vega-Maturino, Azucena Rodríguez‐Mena

et al.

Revista Agraria, Journal Year: 2024, Volume and Issue: 22(1), P. 10 - 14

Published: March 13, 2024

Sweet potato is a food of great relevance worldwide; however, its consumption in Mexico remains low despite nutritional value and the diversity available varieties. Consumer demand for more natural less processed recent years foods has increased. A new, opportunity emerged industry to replace artificial colorants with alternatives.In this context, obtaining pigments from purple-fleshed sweet potatoes presents viable option due their high anthocyanin content. These are ideal candidates replacing synthetic colorants, as they can produce variety shades, ranging reds blues, depending on extraction conditions. This versatility broadens application different products. In addition being an using color industry, represent promote leverage potential health benefits. Highlighting aims increase visibility, encourage use, take advantages

Language: Английский

Cyanidin-3-O-glucoside inhibits the malignant progression of colorectal cancer by regulating Kruppel-like factor 4-mediated ERK/p38 signaling pathway DOI
Jian Chang,

Geqiong Xiao

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: 497, P. 117268 - 117268

Published: Feb. 17, 2025

Language: Английский

Citations

0
Acute and subacute toxicity evaluation of ZhenzhuXiaoji decoction in preclinical models: implications for safe clinical use DOI Creative Commons
Songzhe Li,

Shuchang Bao,

Lingyun Cai

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 15, 2025

Background ZhenzhuXiaoji Decoction (ZZXJD) is a traditional Chinese medicine formulation composed of five herbs: Ligustrum lucidum , Curcuma zedoaria Prunella vulgaris Hedyotis diffusa and Glycyrrhiza uralensis developed for the treatment hepatocellular carcinoma (HCC). Although early studies have demonstrated therapeutic potential ZZXJD, its safety profile, particularly regarding toxicity, remains underexplored. This study aims to evaluate both pharmacological effects toxicity ZZXJD in preclinical models determine clinical applicability. Study design Methods employed vitro vivo experiments assess ZZXJD. HHL-5 HEK-293 cell lines were treated with at varying concentrations (125, 250, 500, 1,000 μg/mL) 24, 48, 72 h on viability, apoptosis, necrosis. Acute subacute conducted male female mice, including assessments behavioral changes, body weight, organ liver/kidney functions. Additionally, routine blood tests performed identify immunostimulatory effects. Results In that inhibited proliferation cells dose-dependent manner induced apoptosis studies, mice low mid-dose groups exhibited no significant whereas high-dose group showed transient alterations liver kidney function markers, mice. These changes reversible following cessation. Blood indicated increased lymphocyte monocyte counts mice; however, these increases not statistically significant. Organ weight histopathological analyses revealed signs doses. Conclusion Treatment standard dosage did produce acute or toxic functions suggesting continued use cancer treatment. However, abnormalities markers observed higher Thus, regular monitoring recommended during use, especially when doses are employed.

Language: Английский

Citations

0
Catalase-Knockout Complements the Radio-Sensitization Effect of Titanium Peroxide Nanoparticles on Pancreatic Cancer Cells DOI Creative Commons
Winda Tasia,

Amane Washio,

Koki Yamate

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 629 - 629

Published: Jan. 31, 2025

In previous studies, titanium peroxide nanoparticles (PAA-TiOx NPs) with surfaces functionalized using polyacrylic acid (PAA) and hydrogen (H2O2) demonstrated a synergistic effect when combined X-ray irradiation. The combination generated H2O2 reactive oxygen species (ROS) that enhanced the irradiation efficacy. present study, we examined relationship between catalase PAA-TiOx NPs sensitization to radiation because is primary antioxidant enzyme converts water oxygen. Catalase-knockout PANC-1 (dCAT) cells were CRISPR/Cas9 system, which was confirmed by suppression of expression in mRNA protein levels resulted an 81.7% decrease activity compared wild-type cells. Catalase deficiency found increase production ROS, particularly hypoxia. Also, 5 Gy 7-fold survival fraction (SF; p < 0.01) dCAT rates documented Interestingly, treatment 3 SF similar observed treated same but at higher dose (5 Gy). These results suggest strategy inhibition could be used establish advanced for pancreatic cancer

Language: Английский

Citations

0
Aronia-derived anthocyanins and metabolites ameliorate TNFα-induced disruption of myogenic differentiation in satellite cells DOI
Xiaocao Liu,

Nina Shangguan,

Fulong Zhang

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 733, P. 150687 - 150687

Published: Sept. 14, 2024

Language: Английский

Citations

1
Camote de pulpa morada (Ipomoea batatas L.) y sus antocianinas: de postre tradicional a fuente de colorante natural DOI
Luz Araceli Ochoa‐Martínez, Sandra Vega-Maturino, Azucena Rodríguez‐Mena

et al.

Revista Agraria, Journal Year: 2024, Volume and Issue: 22(1), P. 10 - 14

Published: March 13, 2024

Sweet potato is a food of great relevance worldwide; however, its consumption in Mexico remains low despite nutritional value and the diversity available varieties. Consumer demand for more natural less processed recent years foods has increased. A new, opportunity emerged industry to replace artificial colorants with alternatives.In this context, obtaining pigments from purple-fleshed sweet potatoes presents viable option due their high anthocyanin content. These are ideal candidates replacing synthetic colorants, as they can produce variety shades, ranging reds blues, depending on extraction conditions. This versatility broadens application different products. In addition being an using color industry, represent promote leverage potential health benefits. Highlighting aims increase visibility, encourage use, take advantages

Language: Английский

Citations

0