Archives of Dermatological Research, Journal Year: 2024, Volume and Issue: 316(8)
Published: Aug. 23, 2024
Language: Английский
International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(5), P. 1778 - 1795
Published: Jan. 1, 2024
Skin tissue, composed of epidermis, dermis, and subcutaneous is the largest organ human body.It serves as a protective barrier against pathogens physical trauma plays crucial role in maintaining homeostasis.Skin diseases, such psoriasis, dermatitis, vitiligo, are prevalent can seriously impact quality patient life.Exosomes lipid bilayer vesicles derived from multiple cells with conserved biomarkers important mediators intercellular communication.Exosomes skin cells, blood, stem main types exosomes that involved modulating microenvironment.The dysregulation exosome occurrence transmission, well alterations their cargoes, complex pathogenesis inflammatory autoimmune diseases.Therefore, promising diagnostic therapeutic targets for diseases.Importantly, exogenous exosomes, or play improving environment repairing damaged tissues by carrying various specific active substances involving variety pathways.In domain clinical practice, have garnered attention prospective agents including psoriasis vitiligo.Furthermore, investigations substantiated regenerative efficacy cell-derived repair.In this review, we mainly summarize latest studies about mechanisms applications dermatology, atopic systemic lupus erythematosus, sclerosis, diabetic wound healing, hypertrophic scar keloid, aging.This will provide novel perspective diagnosis treatment dermatosis.
Language: Английский
Citations
21
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 8, 2024
Exosome-derived microRNAs (miRNAs) are biomacromolecules and nanoscale extracellular vesicles originating from intracellular compartments that secreted by most cells into the space. This review examines formation function of exosomal miRNAs in biological information transfer, explores pathogenesis vitiligo, highlights relationship between vitiligo. The aim is to deepen understanding how influence immune imbalance, oxidative stress damage, melanocyte-keratinocyte interactions, melanogenesis disorders development enhanced may contribute potential diagnostic therapeutic options for
Language: Английский
Citations
5
Expert Opinion on Therapeutic Targets, Journal Year: 2023, Volume and Issue: 27(3), P. 189 - 206
Published: March 4, 2023
Introduction The treatment of vitiligo remains challenging due to the complexity its pathogenesis, influenced by genetic factors, oxidative stress and abnormal cell adhesion that collectively impact melanocyte survival trigger immune system attacks, resulting in death. Melanocytes are believed exhibit susceptibility defects cellular mechanisms, such as autophagy, reduce their ability resist stress, leading increased expression pro-inflammatory protein HSP70. low molecules, DDR1 E-cadherin, accelerates damage antigen exposure. Consequently, autoimmune attacks centered on IFN-γ-CXCR9/10-CXCR3-CD8+ T cells initiated, causing vitiligo.
Language: Английский
Citations
12
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Dec. 1, 2023
Exosomes, bilaterally phospholipid-coated small vesicles, are produced and released by nearly all cells, which comprise diverse biological macromolecules, including proteins, DNA, RNA, others, that participate in the regulation of their functions. An increasing number studies have revealed contents exosomes, particularly microRNA(miRNA), play a significant role pathogenesis various diseases, autoimmune skin diseases. MiRNA is class single-stranded non-coding RNA molecules possess approximately 22 nucleotides length with capability binding to untranslated as well coding regions target mRNA regulate gene expression precisely at post-transcriptional level. Various exosomal miRNAs been found be significantly expressed some diseases involved conditions via regulating secretion crucial pathogenic cytokines direction immune cell differentiation. Thus, might promising biomarkers for monitoring disease progression, relapse reflection treatment based on functions changes. This review summarized current several common aiming dissect underlying mechanism from new perspective, seek novel lay foundation developing innovative therapy future.
Language: Английский
Citations
12
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143070 - 143070
Published: April 1, 2025
Language: Английский
Citations
0
Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)
Published: April 9, 2025
Language: Английский
Citations
0
JAAD reviews., Journal Year: 2024, Volume and Issue: 1, P. 135 - 174
Published: July 14, 2024
The clinical exploration of extracellular vesicles (EVs, also called exosomes) in dermatology has recently grown, including cosmeceuticals. This systematic review aimed to collate existing observations on EVs for either therapeutic intervention or as a diagnostic prognostic tool and critically assess the degree evidence any observed feature. Primary studies that enrolled patients with dermatologic conditions reported role were included. Screening analysis, data extraction, quality assessment performed by 4 investigators. GRADE-CERQual, an adapted approach assessing certainty qualitative sytematic reviews, was utilized determine confidence data. Outcomes included effectiveness EVs' formulations, their safety, potential. Fifty-two reporting from 3066 Methodologic inconsistencies, poor reporting, low numbers reduced certainty. potential utilization studied but have not been validated. are being introduced into practices globally Observational implied some efficacy, regulatory perspective, our knowledge, no EV-based therapeutics approved dermatology. Future trials need be randomized, double-blind, placebo-controlled support approvals, findings supported larger cohorts.
Language: Английский
Citations
2
Archives of Dermatological Research, Journal Year: 2024, Volume and Issue: 316(8)
Published: Aug. 23, 2024
Language: Английский
Citations
1