The 675‐nm wavelength for treating facial melasma

Skin Research and Technology, Journal Year: 2023, Volume and Issue: 29(8)

Published: Aug. 1, 2023

Melasma is an acquired skin problem. It characterises sun-exposed areas, particularly on the face, with irregular borders and bilateral distribution. With this study, we want to strengthen scientific literature regarding use of a 675-nm laser device for treatment women men facial melasma pigmentary vascular symptoms.

Language: Английский

---

Platelet-Rich Plasma in Dermatology: New Insights on the Cellular Mechanism of Skin Repair and Regeneration

Life, Journal Year: 2023, Volume and Issue: 14(1), P. 40 - 40

Published: Dec. 25, 2023

The skin's recognised functions may undergo physiological alterations due to ageing, manifesting as varying degrees of facial wrinkles, diminished tautness, density, and volume. Additionally, these can be disrupted (patho)physiologically through various physical chemical injuries, including surgical trauma, accidents, or chronic conditions like ulcers associated with diabetes mellitus, venous insufficiency, obesity. Advancements in therapeutic interventions that boost the innate regenerative abilities could significantly enhance patient care protocols. application Platelet-Rich Plasma (PRP) is widely recognized for its aesthetic functional benefits skin. Yet, endorsement PRP's advantages often borders on dogmatic, efficacy commonly ascribed solely activation fibroblasts by factors contained within platelet granules. PRP therapy a cornerstone medicine which involves autologous delivery conditioned plasma enriched platelets. This achieved centrifugation, removing erythrocytes while retaining platelets their Despite widespread use, precise sequences cellular activation, specific players, molecular machinery drive PRP-facilitated healing are still enigmatic. There paucity definitive robust studies elucidating mechanisms. In recent years, telocytes (TCs)-a unique dermal cell population-have shown promising potential tissue regeneration organs, dermis. TCs' participation neo-angiogenesis, akin attributed PRP, role remodelling repair processes interstitia several organs (including dermis), offer intriguing insights. Their contribute to, possibly orchestrate, skin process following treatment has elicited considerable interest. Therefore, pursuing comprehensive understanding mechanisms at work, particularly those involving TCs, temporal involvement structural recovery injury, interconnected biological events wound represents compelling field study.

Language: Английский

---

Interruption of p38^MAPK-MSK1-CREB-MITF-M pathway to prevent hyperpigmentation in the skin

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(5), P. 1688 - 1704

Published: Jan. 1, 2024

Background: Melanocortin 1 receptor (MC1R), a of α-melanocyte-stimulating hormone (α-MSH), is exclusively present in melanocytes where α-MSH/MC1R stimulate melanin pigmentation through microphthalmia-associated transcription factor M (MITF-M).Toll-like 4 (TLR4), endotoxin lipopolysaccharide (LPS), distributed immune and other cell types including LPS/TLR4 activate transcriptional activity nuclear (NF)-κB to express cytokines innate immunity.LPS/TLR4 also up-regulate MITF-M-target melanogenic genes melanocytes.Here, we propose molecular target antimelanogenic elucidating inhibitory mechanism on α-MSH-induced programs by benzimidazole-2-butanol (BI2B), an inhibitor LPS/TLR4-activated NF-κB.Methods: Ultraviolet B (UV-B)-irradiated skins HRM-2 hairless mice α-MSH-activated melanocyte cultures were employed examine programs.Results: Topical treatment with BI2B ameliorated UV-B-irradiated skin hyperpigmentation mice.BI2B suppressed the protein or mRNA levels markers, such as tyrosinase (TYR), MITF-M proopiomelanocortin (POMC), UV-B-exposed pigmented tissues.Moreover, inhibited co-cultures keratinocyte cells that cultures.Mechanistically, activation cAMP response element-binding (CREB) expression at promoter level.As target, primarily mitogen-activated kinase (MAPK) 3 (MKK3)-catalyzed p38 MAPK .Subsequently, interrupted downstream pathway -mitogen stress-activated kinase-1 (MSK1)-CREB-MITF-M, genes, encoding enzymes TYR, TYR-related protein-1 (TRP-1) dopachrome tautomerase (DCT) biosynthesis, proteins PMEL17 Rab27A transfer melanosomes overlaying keratinocytes skin.Conclusion: Targeting MKK3-p38 -MSK1-CREB-MITF-M was suggested rationale inhibit UV-B-or facultative melanogenesis strategy prevent acquired pigmentary disorders skin.

Language: Английский

---

Whole genome resequencing reveals genomic regions related to red plumage in ducks

Poultry Science, Journal Year: 2024, Volume and Issue: 103(6), P. 103694 - 103694

Published: April 5, 2024

Plumage color is a characteristic trait of ducks that originates as result natural and artificial selection. As conspicuous phenotypic feature, it breed characteristic. Previous studies have identified some genes associated with the formation black white plumage in ducks. However, on genetic basis underlying red phenotype are limited. Here, genome-wide association analysis (GWAS) selection signal detection (Fst, θπ ratio, cross-population composite likelihood ratio [XP-CLR]) were conducted to identify candidate regions duck phenotype. Selection revealed 29 overlapping (including ENPP1 ULK1) significantly Ji'an Red ENSAPLG00000012679, ESRRG, SPATA5 using GWAS. 19 GMDS, PDIA6, ODC1) correlated light brown Brown Tsaiya GWAS narrow down significant further nine (AKT1, ATP6V1C2, LRP4, MAML3, PLD5, TMEM63B, TSPAN8). Notably, ducks, ODC1, PDIA6 exhibit differentiated allele frequencies among other feather-colored while ENSAPLG00000012679 has different frequency distributions compared This study offers new insights into variation selective signals.

Language: Английский

---

Effective Components of Panax notoginseng–Salvia miltiorrhiza in the Treatment of Melasma and Its Experimental Study

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Purpose: The main purpose of this study was to predict and verify the active ingredients Panax notoginseng–Salvia miltiorrhiza in melasma based on network pharmacology analysis experimental verification. Materials methods: notoginseng–Salviae miltiorrhizae investigated by pharmacology, GEO database analysis, molecular docking techniques screen its ingredients. components were further validated an vitro α-melanin-induced B16F10 melanoma cell model vivo UV irradiation combined with a progesterone injection-induced rat model. Results: Network showed that salvianolic acid B might be key ingredient. In cellular experiments revealed inhibits tyrosinase activity cells at concentrations 60–90 nmol/mL. animal found TYR, MDA, TNF-α decreased skin serum rats group low-, medium-, high-dose groups B, expression GSH-Px SOD increased. best therapeutic effect. Conclusion: study, collectively show slows down process inhibiting lipid peroxidation organism, increasing antioxidant capacity skin, decreasing tyrosinase, providing anti-inflammation. This highlights successful application provides scientific basis for clinical citation treating melasma.

Language: Английский

---

Melasma Management: Unveiling Recent Breakthroughs through Literature Analysis

Health Sciences Review, Journal Year: 2025, Volume and Issue: unknown, P. 100213 - 100213

Published: Jan. 1, 2025

Language: Английский

---

Association of Genetic Polymorphisms in SLC45A2, TYR, HERC2, and SLC24A in African Women with Melasma: A Pilot Study

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1158 - 1158

Published: Jan. 29, 2025

Melasma is a chronic skin disorder characterized by hyperpigmentation, predominantly affecting women with darker types, including those of African descent. This study investigates the association between genetic variants in SLC45A2, TYR, HERC2, and SLC24A5 genes severity melasma reproductive age. Forty participants were divided into two groups: twenty facial without. Deoxyribonucleic acid (DNA) was extracted from blood samples genotyped using TaqMan assays to identify allele frequencies genotype distributions. Significant associations observed for TYR gene (rs1042602), HERC2 (rs1129038), (rs1426654) polymorphisms, highlighting their potential roles susceptibility. For example, rs1042602 Single Nucleotide Polymorphisms (SNP) showed strong melasma, AA conferring markedly increased risk. Similarly, rs1129038 SNP rs1426654 revealed significant variations groups These findings underscore influence polymorphisms on melasma’s pathogenesis, emphasizing need personalized approaches its treatment, particularly types.

Language: Английский

---

Role of Polyphenols in Dermatological Diseases: Exploring Pharmacotherapeutic Mechanisms and Clinical Implications

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 247 - 247

Published: Feb. 12, 2025

Although not frequently lethal, dermatological diseases represent a common cause of consultation worldwide. Due to the natural and non-invasive approach phytotherapy, research for novel alternatives, such as polyphenols, treat skin disorders is subject interest in modern medicine. Polyphenols, particular, have been considered because their anti-inflammatory, antitumoral, antimicrobial, antioxidant properties, low molecular weight, lipophilic nature that enables passage these compounds through barrier. This review discusses treatment acne vulgaris, fungal infections, dermatitis, alopecia, cancer, using polyphenols therapeutic prophylactic options. The specific molecules each disorder, mechanisms action, current clinical trials, proposed applications are also reviewed.

Language: Английский

---

Assessment of clinical efficacy in melasma treatment with picosecond laser combined with Shumin Star

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Feb. 14, 2025

Language: Английский

---

Evaluating the Efficacy of Tukhm Turb (Raphanus sativus L. Seeds) in Melasma: Insights from Recent Research and Traditional Unani Literature

Journal of Drug Delivery and Therapeutics, Journal Year: 2025, Volume and Issue: 15(2), P. 107 - 111

Published: Feb. 15, 2025

Melasma is a common pigmentary skin condition that predominantly affects individuals with darker or light brown tones, prevalence of up to 70% in pregnant women. Ibn e Sina, renowned Unani scholar, described Kalaf as discoloration resembling melasma its clinical features. The system medicine, known for plant-based remedies, highlights the potential Tukhm Turb (Raphanus sativus seeds), member Brassicaceae family, treating melasma. According principles, possesses Jālī (detergent), Mulaṭṭif (attenuant), Muḥallil (anti-inflammatory), and other beneficial properties. Modern studies corroborate these attributes, demonstrating Raphanus has anti-inflammatory, antioxidant, tyrosinase-inhibiting activities, which are attributed phytochemicals such alkaloids, glucosinolates, brassinosteroids, flavonoids. This review examines traditional use literature evaluates findings from recent pharmacological studies, trials, in-vitro/in-vivo investigations. A systematic search databases PubMed, Google Scholar, ScienceDirect was conducted, alongside classical texts using keywords like “melasma,” “Kalaf,” “Raphanus sativus,” “Raphani semen.” integration modern evidence suggests may be effective managing due multifaceted While promising, further rigorous required validate efficacy establish standard treatment Keywords: Alkaloid, Flavonoid, Kalaf, sativus, Traditional Medicine,

Language: Английский

---