An Update on New and Existing Treatments for the Management of Melasma

American Journal of Clinical Dermatology, Journal Year: 2024, Volume and Issue: 25(5), P. 717 - 733

Published: June 19, 2024

Melasma is a chronic, acquired disorder of focal hypermelanosis that carries significant psychosocial impact and challenging for both the patient treating practitioner to manage in medium long term. Multiple treatments have been explored, often combination given many aetiological factors involved its pathogenesis. Therapeutic discoveries treat melasma are topic literature include range modalities, with recent developments including updates on visible light photoprotection, non-hydroquinone depigmenting agents, oral tranexamic acid, chemical peels, laser energy-based device therapy melasma. It increasingly important yet remain up-to-date arsenal available find an efficacious well-tolerated option our patients.

Language: Английский

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Effectiveness, safety, and patient satisfaction of carboxytherapy as an adjunctive treatment for periorbital hyperpigmentation

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(3)

Published: March 1, 2024

Abstract Introduction Dark under‐eye circles or periorbital hyperpigmentation constitute a prevalent and challenging cosmetic problem with diverse etiologies types. While modifying exacerbating habits can provide partial relief for the pigmentary vascular factors associated this condition, despite abundance of available treatment options, there is currently lack gold‐standard evidence‐based treatments proposed curing disorder. Objectives This study aimed to assess safety effectiveness carboxytherapy in treating hyperpigmentation. Material Methods In 4‐week single‐arm clinical trial, 20 eligible Iranian patients symmetric received weekly intradermal carboxytherapy. The involved administering 10–20 mL CO2 at rate mL/min temperature 15°C duration ranging from few seconds 1 min. Follow‐up assessments were conducted month after final session. primary outcome was defined as changes ΔE variations pigmentation observed between orbital extra‐orbital skin before trial. Results reported satisfaction statistically significant reduction achieved through lateral ( p = 0.002), middle 0.001), medial 0.001) regions area. total response estimated 20%. Patient exceeded changes, no linear relationship 0.084). Conclusion Carboxytherapy be an effective safe

Language: Английский

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The 675‐nm wavelength for treating facial melasma

Skin Research and Technology, Journal Year: 2023, Volume and Issue: 29(8)

Published: Aug. 1, 2023

Melasma is an acquired skin problem. It characterises sun-exposed areas, particularly on the face, with irregular borders and bilateral distribution. With this study, we want to strengthen scientific literature regarding use of a 675-nm laser device for treatment women men facial melasma pigmentary vascular symptoms.

Language: Английский

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A 675 nm Laser in the Treatment of Facial Melasma in Dark Skin Types

Photobiomodulation Photomedicine and Laser Surgery, Journal Year: 2025, Volume and Issue: 43(3), P. 90 - 95

Published: Feb. 3, 2025

Background: Melasma therapy can be difficult and requires employing different treatment approaches. Laser is a good alternative for treating melasma, especially patients with refractory cases. Objective: To evaluate the efficacy safety of newcomer wavelength 675 nm diode laser in melasma darker skin types. Methods: Nineteen female facial were recruited. They received four sessions at one-month intervals using following parameters: power 5-6 W, pulse duration 100-150 ms, spacing 2000 mm, stack one up to 4 passes. One month after last session, evaluation was done subjectively through modified area severity index (mMASI) score objectively Antera 3D camera. Results: After treatment, there highly statistically significant reduction mMASI scores. In addition, scores on camera recorded differences treated areas' melanin hemoglobin average levels. Conclusion: The novel represents safe efficient approach phototype patients.

Language: Английский

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Clinical evidence of high-power 675 nm laser system equipped with a faster treatment modality for the management of pigmented lesions and skin rejuvenation.

JAAD Case Reports, Journal Year: 2025, Volume and Issue: 58, P. 93 - 98

Published: Feb. 4, 2025

Language: Английский

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Comparison of the Efficacy of 1064‐ and 730‐nm Picosecond Lasers for Acquired Dermal Melanocytosis

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(3)

Published: March 1, 2025

ABSTRACT Background Acquired dermal melanocytosis (ADM) is a pigmentary lesion caused by melanocytes in the dermis. These conditions are refractory, and consensus on treatment remains elusive. Aims To compare efficacy of 730‐ 1064‐nm picosecond lasers ADM to supplement comparison with literature review. Patients: We retrospectively examined patients who underwent laser therapy between April 2021 February 2024. Treatments were performed three times spot irradiation using 730‐nm (3‐mm spot, 1.7–1.8 J/cm 2 ; or 2‐mm 2.5–3.25 ) 3.1–4.0 ). Two months after each procedure, patient satisfaction was evaluated questionnaires, macroscopic findings assessed photographs, melanin accumulation analyzed skin analysis software. Evaluations conducted 4‐point scale (excellent, good, fair, poor), good higher considered effective. Results Seventy‐eight 83 assigned groups, respectively. After sessions, group exhibited superior outcomes terms subjective symptoms (patient satisfaction), objective findings, software improvements. The incidence hyperpigmentation 15.4% 14.5% group, no significant differences observed rates other complications. Conclusions use laser, which possesses high selectivity, relatively deep penetration, short pulse width, suggests potentially more effective for ADM, compared effects conventional wavelength, without increasing

Language: Английский

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The Kesty Hyperpigmentation Scale: A Study to Validate a New Tool for Assessing Facial Hyperpigmentation

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(4)

Published: April 1, 2025

ABSTRACT Background Facial hyperpigmentation due to sun damage, post‐inflammatory hyperpigmentation, and other factors is a common complaint of patients. While lasers topical treatments are frequently used manage standardized way measuring response treatment difficult. Aims The Kesty Hyperpigmentation Scale (KHS) novel clinical instrument created provide consistent approach for evaluating facial in both cosmetic dermatology broader medical settings. Methods This study introduces the KHS, describes process its creation validation, examines practical uses Statistical analysis included Gwet's AC2, Kendall's W , Spearman's ρ /rho, weighted Cohen's kappa, Bland–Altman analysis. Results findings statistical high ordinal agreement, strong rank concordance, minimal bias. supports conclusion that rating reliable valid assessing skin on given 0–3 scale. KHS offers an objective framework measure severity helping clinicians track patient progress after treatments, fostering improved communication with Participants this found scale be user‐friendly, majority expressed interest incorporating it into their practices document conditions. Conclusions effective user‐friendly tool addressing significant need within dermatology.

Language: Английский

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Clinical application of 675 nm laser therapy for dorsal hand skin hyperpigmentation

Skin Research and Technology, Journal Year: 2023, Volume and Issue: 29(10)

Published: Oct. 1, 2023

Abstract Background Noninvasive skin rejuvenation treatment is growing in recognition to aesthetic medicine. Aim The objective of the study was assess efficacy and safety 675‐nm laser source photodamaged hands. Materials methods included 21 patients (6 males 15 females) with a mean age 63 (± 9) years. Patients were treated —two three sessions 1‐month interval between sessions. Photos each patient collected at baseline, 3 months after last session. 5‐point Global Aesthetic Improvement Scale (GAIS) recorded their final assessment session (3 months). Results total GAIS scores showed satisfactory results: (71%) experienced 4 score (excellent improvement) changes 6 (29%) (good changes. Clinical images good visible results for management skin. No serious adverse effects recorded. Conclusion This demonstrates improvement pigmentation texture

Language: Английский

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Experience using 675 nm laser on three cases of Fitzpatrick skin type IV‐V with melasma

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Dear Editor, Melasma, predominantly affecting darker skin types, especially those within Fitzpatrick phototypes IV-V.1 The treatment approach is further complicated by high recurrence rates and the significant impact melasma can have on patients' quality of life.2 Laser treatments are a component in management melasma, they generally considered as second-line following first-line use topical therapies. Many studies suggests that low-fluence Q-switched Nd:YAG picosecond laser highlighted potentially effective option this condition when combined with other treatments.3 However, there higher risk post-inflammatory hyperpigmentation (PIH) light treatments. Therefore, these should be used caution therapy after treatments.3, 4 A new non-ablative wavelength 675 nm has been found to significantly improve patients which histologically preclinical shown presence selective damage melanin-rich areas.5, 6 aim article present outcomes types IV-V melasma. By exploring efficacy through clinical cases, we seek contribute limited pool for color provide insights into potential specific managing minimal adverse effects. This prospective case series involved three Indonesian female Skin Types IV-V, presenting facial Exclusion criteria included hypersensitivity light, photosensitizing agents, seizure disorders triggered pregnancy, personal or family history cancer, recent sun exposure, tattoos treated areas, any previous 2 months. system (RedTouch, Deka M.E.L.A., Calenzano, Italy) study, was specifically chosen its effectiveness targeting melanin stimulating collagen remodeling.7 equipped scanning shapes square it adjustable parameters: power, time exposure (dwell time), spot spacing, an integrated cooling feature maintained at 5°C. Before each session, faces were cleansed mild soap water. energy adjusted according patient's type tolerance, determined test area. endpoint erythema oedema, observable 5–10 min. Each patient underwent sessions, spaced 1 month apart. parameters power (5–7 W), dwell (150 ms), spacing (2500 µm), stack (5°C). transparent conductive gel administer treatment. During treatment, handpiece passed over surface contact mode, ensuring consecutive spots without overlapping. Topical anesthesia optional and, if used, thoroughly removed before After cooled cold water-soaked gauzes. nonsteroidal anti-inflammatory cream containing vitamin B12 applied twice daily weeks. Patients instructed total block mineral sunscreen throughout follow-up period. primary outcome change severity, assessed using modified Melasma Area Severity Index (mMASI) scores. Scores recorded start 3 months last session. Digital photographs analyzer (Janus, PIE, Gyeonggi-do, South Korea) taken visually document changes. safety profile evaluated monitoring appearance side effects, including erythematous reactions, blistering, scarring, burns, hypopigmentation, hyperpigmentation. (Figures 1, 2, 3) showed noticeable improvement photographic evidence consistent quantitative mMASI score reductions, confirming treatment's effectiveness. Throughout study duration, no serious effects reported, treating IV-V. Minor transient erythema, resolved intervention. No instances observed. line expectations settings. An informal assessment satisfaction indicated levels outcomes. reported improvements their expressed ease comfort process. absence downtime contributed overall positive experience. demonstrates types. Studies pigmentary improvements, marking condition​​.8 aligns observed involving where notable lesions documented. reduction scores across all cases underscores laser's addressing hyperpigmentation​​. Additionally, corroborated research highlighting low interaction hemoglobin, thereby minimizing risks associated such types​​​​.6, 9 Red-spectrum emission effectively targets fibers, showing strong affinity chromophores. In contrast, interacts minimally vascular chromophore.10 Histologically, induce remodeling collagen, promoting proliferation fibers. plays crucial role pivotal hyperpigmentation​​.5, not superficial but extends substantial dermal changes, evidenced increased production rearrangement areas compared untreated ones. Such histological provides deeper understanding mechanism action, contributing melasma​​.9 While promising, considerations regarding protocols crucial. Adjustments careful essential cater individual needs minimize hyperpigmentation, types​​.6, 7 Furthermore, feedback well downtime, positively experience​​. presents promising referenced indicate enhanced appearance. Importantly, well-suited reducing initial results encouraging, ongoing larger-scale validate findings optimize broader application long-term individuals type. Conceptualization, Ruri D. Pamela, Massimo DF. Vitale, Kyu-Ho Yi; methodology, software, validation, Yi, Tiziano Zingoni; formal analysis, investigation, re-sources, data curation, writing—original draft preparation writing—review editing, Zingoni, Irene Fusco; visualization, supervision, project administration, funding acquisition, All authors read agreed published version manuscript. Authors T.Z. I.F. employed El.En. Group. remaining confirm commercial financial relationships could construed conflict interest existed during research. accordance Declaration Helsinki Ethical Principles Medical Research human subjects. approval necessary device already CE marked since 2019.

Language: Английский

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High‐powered 675‐nm laser: Safety and efficacy in clinical evaluation and in vitro evidence for different skin disorders

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(9)

Published: Aug. 29, 2024

Abstract Background Laser technology is a viable therapeutic option for treating number of skin pathologic conditions, including pigmented lesions, vascular lesions and acne scars. Aim In this work, through in vitro clinical investigations we test the efficacy, safety speed treatment high‐powered laser system emitting 675‐nm management various condition. Materials methods experiments were performed irradiating adult human dermal fibroblasts cells (HDFa) with 24, 48 72 h different fluences Ki‐67 + counted. The confocal microscopy images control treated samples acquired. Clinical rejuvenation/diseases treatments 675 nm device parameters 11 patients 5 scars 23 rejuvenation. Data evaluated validated global score using 5‐point scales (GAIS) patient's satisfaction scale. Results application high‐power has proven effective stimulating cell proliferation it led to good results all pathologies. GAIS showed values between 3 4 points pathologies, scores ‘75%‐good improvements’ ‘100%‐excellent improvements’. time was reduced by 50% compared old setting, resulting faster satisfying technique. No serious adverse effects recorded. Conclusion: preclinical data confirm efficacy several

Language: Английский

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