Recent Advances in Drug Development for Hair Loss DOI Open Access

Jino Kim,

Seung Yong Song, Jong‐Hyuk Sung

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3461 - 3461

Published: April 8, 2025

Hair loss disorders pose a substantial global health burden, affecting millions of individuals and significantly impacting quality life. Despite the widespread use approved therapeutics like minoxidil finasteride, their clinical efficacy remains limited. These challenges underscore pressing need for more targeted effective therapeutic solutions. This review examines latest innovations in hair drug discovery, with focus on small-molecule inhibitors, biologics, stem cell-based therapies. By integrating insights from molecular mechanisms leveraging advancements research methods, development next-generation holds potential to transform management disorders. Future should prioritize antibody therapy treatments, as these approaches offer unprecedented opportunities address limitations existing options. Antibody therapies enable precise targeting key pathways involved follicle regulation, providing highly specific interventions. Similarly, therapies, including cell transplantation dermal papilla regeneration, directly regenerative capacity follicles, offering transformative restoration.

Language: Английский

Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities DOI Open Access

Yozahandy A Abarca,

Renee Scott-Emuakpor,

Jhanavi Tirth

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Alopecia areata (AA) is an autoimmune condition that presents with non-scarring hair loss affecting multiple patients worldwide during their lifetime. It ranges from well-defined patchy to diffuse total loss, impacting all hair-bearing areas of the body. AA most commonly predominantly manifests on scalp. The pathophysiology complex and multi-faceted. findings our review article were consistent recent literature, delineating autoimmunity, genetic susceptibility, environmental aspects be contributing factors. One main causes believed disruption in immune privilege follicles. Multiple loci involved follicle maturation process have been linked development as evidenced by several studies. has postulated psychological stressors, smoking, alcohol consumption, sleep disturbances, gut microbiota, drugs play a role pathogenesis exacerbating response against clinically diagnosed disorder. Topical, intra-lesional, oral corticosteroids, topical minoxidil, cyclosporine, other therapy are widely accepted first-line treatment options, although incomplete remission relapses common. Recently JAK-2 inhibitors mesenchymal stem cell exosomes shown promising results, potentially treating severe refractory loss. bidirectional relationship symptoms it can lead social anxiety depression, which turn aggravate Hence, crucial implement holistic approach managing including systemic therapies, counseling, lifestyle modifications. imperative fully declinate pathophysiological mechanisms disease formulate therapies future research help clinicians dermatologists devise definitive guidelines treat for long-term remission.

Language: Английский

Citations

1
Exosomes in Dermatological Research: Unveiling Their Multifaceted Role in Cellular Communication, Healing, and Disease Modulation DOI Creative Commons
Daniela Pinto,

Giammaria Giuliani,

Giorgia Mondadori

et al.

Cosmetics, Journal Year: 2025, Volume and Issue: 12(1), P. 16 - 16

Published: Jan. 22, 2025

Exosomes, a subtype of extracellular vehicles (EVs), play pivotal role in cellular communication and have gained considerable attention dermatological research. Formed through the inward budding endosomal membrane, exosomes facilitate transfer proteins, lipids, nucleic acids, including microRNAs (miRNAs), thereby influencing behavior function recipient cells. These vesicles are secreted by various cell types, keratinocytes, crucial for maintaining skin homeostasis, regulating immune responses, promoting wound healing. Exosomes demonstrated therapeutic potential addressing conditions such as hair disorders, cancers photoaging enhanced regeneration reduced oxidative stress. However, they also implicated disease progression, with pathogens utilizing exosome release to evade host responses. Recent studies highlight diverse origins functions exosomes, suggesting their promise innovative agents dermatology. As research continues elucidate multifaceted roles, represent frontier understanding intercellular developing novel treatments skin-related diseases, underscoring impact on both health clinical applications. This review synthesizes existing literature biology isolation focus implications contexts.

Language: Английский

Citations

0
The Role of Mesenchymal Stem Cell-Derived Exosomes in Skin Regeneration, Tissue Repair, and the Regulation of Hair Follicle Growth DOI
Nazli Karimi Ahmadi,

Adnan Berk Dinçsoy

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Exosomes DOI

Milan Minesh Hirpara,

Michelle Nguyen, Natasha Atanaskova Mesinkovska

et al.

Advances in Cosmetic Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Citations

0
Effectiveness of Extracellular Vesicle Application in Skin Aging Treatment and Regeneration: Do We Have Enough Evidence from Clinical Trials? DOI Open Access
Anna Domaszewska-Szostek, Marta Krzyżanowska, Agnieszka Polak

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2354 - 2354

Published: March 6, 2025

In recent years, there has been a dynamic development in therapies utilizing extracellular vesicles (EVs) including exosomes. Therefore, we have conducted an analysis of the scientific literature to verify current state knowledge about these therapies. A total 12 clinical studies were analyzed, covering use EVs treating skin aging, acne scars, alopecia, and wound healing. The results indicate that exosomes hold potential regenerative therapies, offering innovative non-invasive therapeutic approaches. At same time, significant challenges related standardization their production lack large-scale randomized identified. Thus, also evaluated investigated trials regard MISEV (Minimal Information for Studies Extracellular Vesicles) criteria. This review provides comprehensive overview contemporary applications therapy medicine, highlighting directions further research.

Language: Английский

Citations

0
Recent Advances in Drug Development for Hair Loss DOI Open Access

Jino Kim,

Seung Yong Song, Jong‐Hyuk Sung

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3461 - 3461

Published: April 8, 2025

Hair loss disorders pose a substantial global health burden, affecting millions of individuals and significantly impacting quality life. Despite the widespread use approved therapeutics like minoxidil finasteride, their clinical efficacy remains limited. These challenges underscore pressing need for more targeted effective therapeutic solutions. This review examines latest innovations in hair drug discovery, with focus on small-molecule inhibitors, biologics, stem cell-based therapies. By integrating insights from molecular mechanisms leveraging advancements research methods, development next-generation holds potential to transform management disorders. Future should prioritize antibody therapy treatments, as these approaches offer unprecedented opportunities address limitations existing options. Antibody therapies enable precise targeting key pathways involved follicle regulation, providing highly specific interventions. Similarly, therapies, including cell transplantation dermal papilla regeneration, directly regenerative capacity follicles, offering transformative restoration.

Language: Английский

Citations

0