Bacterial cellulose: Is it really a promising biomedical material?

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123427 - 123427

Published: Feb. 22, 2025

Language: Английский

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In situ oxygen-generating bio-heterojunctions for enhanced anti-bacterial treatment of anaerobe-induced periodontitis

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155083 - 155083

Published: Aug. 23, 2024

Language: Английский

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Dexketoprofen-Loaded Alginate-Grafted Poly(N-vinylcaprolactam)-Based Hydrogel for Wound Healing

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3051 - 3051

Published: March 26, 2025

All acute and chronic wound management strategies have limitations. Therefore, there is an urgent need to develop new treatment options for healing. Hydrogels based on natural polymers offer advantages in because they can reduce patients' pain, fight infection, carry targeted drugs speed up the healing process. In this study, we aimed investigate alginate-grafted N-vinylcaprolactam-based matrix a modified release of dexketoprofen (DEX), which potentially useful Free radical polymerization grafted techniques were used prepare thermo-responsive hydrogels. The obtained hydrogels, unloaded hydrogel (HY) dexketoprofen-loaded (DEXHY), characterized analyzed. concentration DEX encapsulated polymer was 4 mg/mL. IC50 values found samples tested by us 607.4 µg/mL HY, 950.4 DEXHY, 2239 DEX. average value cell viability (%) after exposure cells DEXHY 75.4%. exhibited very good vitro closure rate, given its ability modify kinetics. developed study has shown considerable potential facilitate even accelerate healing, including surgical wounds, inhibiting overexpressed inflammation

Language: Английский

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S-nitrosoglutathione releasing nano-micron combination hy-drogel enhances cutaneous wound healing via promoting an-giogenesis and collagen deposition

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: April 7, 2025

Nitric oxide (NO) is essential for wound healing, promoting angiogenesis and collagen deposition. This study investigates a novel dual-matrix nanocomposite hydrogel incorporating S-nitrosoglutathione (GSNO), physiological NO donor, to enhance cutaneous healing. GSNO was encapsulated in ammonio methacrylate copolymer nanoparticles embedded an alginate-based matrix, achieving controlled release. GSNO-loaded were prepared using solvent displacement evaporation methods, resulting spherical, well-distributed positively charged particles. These cross-linked with negatively alginic acid form hydrogel. The hydrophobic protected from degradation, while the hydrophilic alginate matrix sustained release of active up 10 h, haemostasis maintaining moist environment. exhibited good biocompatibility human fibroblasts significantly enhanced repair by fibroblast formation, neovascularisation deposition, as demonstrated haematoxylin eosin staining Masson's trichrome staining. In conclusion, accelerated healing process enhancing offering promising strategy improving

Language: Английский

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Temperature-Responsive Hydrogel System Integrating Wound Temperature Monitoring and On-demand Drug Release for Sequentially Inflammatory Process Regulation of Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Wound healing faces challenges like inflammation, infection, and limited monitoring capabilities, traditional dressings often lack the ability to promote or provide real-time wound status updates. Early pro-inflammatory responses help clear pathogens damaged tissue, while timely anti-inflammatory modulation aids tissue regeneration, making sequential inflammation regulation crucial. Additionally, temperature, a key infection biomarker, enables for effective management. We propose temperature-responsive hydrogel dressing capable of two-stage drug release temperature monitoring. The hydrogel, composed poly(N-isopropylacrylamide) (PNIPAM) dopamine/methacrylated-modified hyaluronic acid (HA–MA–DA), allows temperature-based control, regulating stages in healing. Interleukin-8 (IL-8), molecule, is encapsulated into matrix rapidly released trigger initial inflammatory response. Furthermore, photothermally responsive erastin-loaded polydopamine@PNIPAM nanoparticles (E-PD NPs) are incorporated erastin upon near-infrared light exposure, terminating through cytosolic burial, thus achieve effects at second stage bluetooth module Combining with monitoring, our addresses significant gaps current technologies offers new insights personalized therapeutic interventions.

Language: Английский

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Cooling wound dressings: Prospects for clinical practice

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(10)

Published: Oct. 1, 2024

Language: Английский

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