Cells,
Journal Year:
2022,
Volume and Issue:
12(1), P. 34 - 34
Published: Dec. 22, 2022
In
recent
years,
the
improvement
in
health
and
social
conditions
has
led
to
an
increase
average
lifespan.
Since
aging
is
most
important
risk
factor
for
majority
of
chronic
human
diseases,
development
therapies
intervention
stop,
lessen
or
even
reverse
various
age-related
morbidities
target
ameliorate
quality
life
elderly.
The
gut
microbiota,
that
is,
complex
ecosystem
microorganisms
living
gastrointestinal
tract,
plays
role,
not
yet
fully
understood,
maintaining
host’s
homeostasis,
influencing
metabolic,
oxidative
cognitive
status;
this
reason,
it
also
named
“the
forgotten
endocrine
organ”
second
brain”.
On
other
hand,
microbiota
diversity
richness
are
affected
by
unmodifiable
factors,
such
as
sex,
modifiable
ones,
diet,
pharmacological
lifestyle.
review,
we
discuss
changes,
mostly
disadvantageous,
health,
induced
aging,
composition
effects
dietary
intervention,
supplementation
with
probiotics,
prebiotics,
synbiotics,
psychobiotics
antioxidants
physical
exercise.
integrated
strategy
implement
will
help
goal
healthy
aging.
Neural Regeneration Research,
Journal Year:
2020,
Volume and Issue:
16(4), P. 628 - 628
Published: Oct. 9, 2020
Neurodegenerative
disease
etiology
is
still
unclear,
but
different
contributing
factors,
such
as
lifestyle
and
genetic
factors
are
involved.
Altered
components
of
the
gut
could
play
a
key
role
in
gut-brain
axis,
which
bidirectional
system
between
central
nervous
enteric
system.
Variations
composition
microbiota
its
function
healthy
people
patients
have
been
reported
for
variety
human
disorders
comprising
metabolic,
autoimmune,
cancer,
and,
notably,
neurodegenerative
disorders.
Diet
can
alter
composition,
affecting
axis
function.
Different
nutraceutical
interventions
devoted
to
normalizing
microbiome
dysbiosis
improving
biological
outcomes
neurological
conditions,
including
use
probiotics.
Preclinical
clinical
investigations
discussed
this
review
strengthen
correlation
intestinal
brain
concept
that
modifying
may
improve
neurochemistry,
modulating
pathways.
This
will
discuss
potential
probiotics
Parkinson's
prevention
or
treatment
adjuvant
therapy,
confirming
modulation
influences
pro-survival
Future
should
consider
additional
comprehension
underlying
mechanisms
extremely
necessary.
Ageing Research Reviews,
Journal Year:
2021,
Volume and Issue:
70, P. 101414 - 101414
Published: July 26, 2021
Chronic
(neuro)inflammation
plays
an
important
role
in
many
age-related
central
nervous
system
(CNS)
diseases,
including
Alzheimer's
disease,
Parkinson's
disease
and
vascular
dementia.
Inflammation
also
characterizes
conditions
that
form
a
risk
factor
for
these
CNS
disorders,
such
as
physical
inactivity,
obesity
cardiovascular
disease.
Lipocalin
2
(Lcn2)
is
inflammatory
protein
shown
to
be
involved
different
well
thereof.
Lcn2
expression
increased
the
periphery
brain
diseases
their
conditions.
Experimental
studies
indicate
contributes
various
neuropathophysiological
processes
of
exacerbated
neuroinflammation,
cell
death
iron
dysregulation,
which
may
negatively
impact
cognitive
function.
We
hypothesize
levels
result
sensitize
increase
develop
diseases.
In
this
review
we
first
provide
comprehensive
overview
known
functions
Lcn2,
its
effects
CNS.
Subsequently,
explores
potential
(neuro)inflammatory
link
between
development
disorders.
Altogether,
evidence
convincingly
indicates
key
constituent
ageing
Ageing Research Reviews,
Journal Year:
2021,
Volume and Issue:
69, P. 101351 - 101351
Published: May 7, 2021
Untangling
the
interdependency
of
infections,
immunity
and
frailty
may
help
to
clarify
their
roles
in
maintenance
health
aging
individuals,
recent
COVID-19
pandemic
has
further
highlighted
such
priority.
In
this
scoping
review
we
aimed
systematically
collect
evidence
on
1)
impact
common
infections
as
influenza,
pneumonia
varicella
zoster
development,
2)
role
played
by
response
immunization
older
adults.
Findings
are
discussed
under
a
unifying
framework
identify
knowledge
gaps
outline
clinical
public
implications
foster
healthier
aging.
Twenty-nine
studies
(113,863
participants)
selected
answer
first
question
provided
moderately
strong
an
association
between
physical
well
cognitive
decline
–
two
essential
dimensions
frailty.
Thirteen
(34,520
investigating
second
aim,
showed
that
was
associated
with
impaired
immune
ages,
likely
due
immunosenescence.
However,
paucity
studies,
absence
tools
predict
vaccine
efficacy,
lack
efficacy
newer
vaccines
presence
frailty,
strongly
limit
formulation
more
personalized
strategies
for
The
current
suggests
repeatedly
cross
each
other
pathophysiological
paths
accelerate
process
vicious
circle.
Such
opens
several
considerations.
First,
prevention
both
conditions
pass
through
life
course
approach,
which
includes
individual
societal
aspects.
Second,
well-functioning
system
be
accomplished
preventing
vice
versa.
Third,
increasing
adherence
delay
onset
maintain
homeostasis,
beyond
infections.
Cells,
Journal Year:
2022,
Volume and Issue:
12(1), P. 34 - 34
Published: Dec. 22, 2022
In
recent
years,
the
improvement
in
health
and
social
conditions
has
led
to
an
increase
average
lifespan.
Since
aging
is
most
important
risk
factor
for
majority
of
chronic
human
diseases,
development
therapies
intervention
stop,
lessen
or
even
reverse
various
age-related
morbidities
target
ameliorate
quality
life
elderly.
The
gut
microbiota,
that
is,
complex
ecosystem
microorganisms
living
gastrointestinal
tract,
plays
role,
not
yet
fully
understood,
maintaining
host’s
homeostasis,
influencing
metabolic,
oxidative
cognitive
status;
this
reason,
it
also
named
“the
forgotten
endocrine
organ”
second
brain”.
On
other
hand,
microbiota
diversity
richness
are
affected
by
unmodifiable
factors,
such
as
sex,
modifiable
ones,
diet,
pharmacological
lifestyle.
review,
we
discuss
changes,
mostly
disadvantageous,
health,
induced
aging,
composition
effects
dietary
intervention,
supplementation
with
probiotics,
prebiotics,
synbiotics,
psychobiotics
antioxidants
physical
exercise.
integrated
strategy
implement
will
help
goal
healthy
aging.
