Ageing Research Reviews,
Journal Year:
2022,
Volume and Issue:
82, P. 101767 - 101767
Published: Oct. 22, 2022
A
growing
body
of
evidence
has
shown
that
people
with
chronic
low
back
pain
(CLBP)
demonstrate
significantly
greater
declines
in
multiple
cognitive
domains
than
who
do
not
have
CLBP.
Given
the
high
prevalence
CLBP
ever-growing
aging
population
may
be
more
vulnerable
to
decline,
it
is
important
understand
mechanisms
underlying
accelerated
decline
observed
this
population,
so
proper
preventive
or
treatment
approaches
can
developed
and
implemented.
The
current
scoping
review
summarizes
what
known
regarding
potential
suboptimal
performance
discusses
future
research
directions.
Five
were
identified
based
on
findings
from
34
included
studies:
(1)
altered
activity
cortex
neural
networks;
(2)
grey
matter
atrophy;
(3)
microglial
activation
neuroinflammation;
(4)
comorbidities
associated
CLBP;
(5)
gut
microbiota
dysbiosis.
Future
studies
should
deepen
understanding
association
prevention
strategies
developed.
Molecular Neurodegeneration,
Journal Year:
2022,
Volume and Issue:
17(1)
Published: March 5, 2022
The
implication
of
gut
microbiota
in
the
control
brain
functions
health
and
disease
is
a
novel,
currently
emerging
concept.
Accumulating
data
suggest
that
exert
its
action
at
least
part
by
modulating
neuroinflammation.
Given
link
between
neuroinflammatory
changes
neuronal
activity,
it
plausible
may
affect
indirectly
impacting
microglia,
key
player
Indeed,
increasing
evidence
suggests
interplay
microglia
synaptic
dysfunction
involve
microbiota,
among
other
factors.
In
addition
to
these
indirect
microglia-dependent
actions
on
has
been
recently
recognized
could
also
activity
directly
stimulation
vagus
nerve.
Molecular Neurodegeneration,
Journal Year:
2022,
Volume and Issue:
17(1)
Published: June 17, 2022
A
consequence
of
our
progressively
ageing
global
population
is
the
increasing
prevalence
worldwide
age-related
cognitive
decline
and
dementia.
In
absence
effective
therapeutic
interventions,
identifying
risk
factors
associated
with
becomes
increasingly
vital.
Novel
perspectives
suggest
that
a
dynamic
bidirectional
communication
system
between
gut,
its
microbiome,
central
nervous
system,
commonly
referred
to
as
microbiota-gut-brain
axis,
may
be
contributing
factor
for
health
disease.
However,
exact
mechanisms
remain
undefined.
Microbial-derived
metabolites
produced
in
gut
can
cross
intestinal
epithelial
barrier,
enter
systemic
circulation
trigger
physiological
responses
both
directly
indirectly
affecting
functions.
Dysregulation
this
(i.e.,
dysbiosis)
modulate
cytotoxic
metabolite
production,
promote
neuroinflammation
negatively
impact
cognition.
review,
we
explore
critical
connections
microbial-derived
(secondary
bile
acids,
trimethylamine-N-oxide
(TMAO),
tryptophan
derivatives
others)
their
influence
upon
function
neurodegenerative
disorders,
particular
interest
less-explored
role
decline.
Metabolites,
Journal Year:
2022,
Volume and Issue:
12(11), P. 1064 - 1064
Published: Nov. 3, 2022
The
gut-brain
axis
is
a
bidirectional
communication
network
connecting
the
gastrointestinal
tract
and
central
nervous
system.
keeps
track
of
activities
integrates
them
to
connect
gut
health
higher
cognitive
parts
brain.
Disruption
in
this
connection
may
facilitate
various
neurological
problems.
Neurodegenerative
diseases
are
characterized
by
progressive
dysfunction
specific
populations
neurons,
determining
clinical
presentation.
Misfolded
protein
aggregates
that
cause
cellular
toxicity
aid
collapse
proteostasis
defining
characteristic
neurodegenerative
proteinopathies.
These
disorders
not
only
caused
changes
neural
compartment
but
also
due
other
factors
non-neural
origin.
Mounting
data
reveal
majority
(GI)
physiologies
mechanics
governed
system
(CNS).
Furthermore,
microbiota
plays
critical
role
regulation
physiological
function
brain,
although
mechanism
involved
has
yet
been
fully
interpreted.
One
emerging
explanations
start
progression
many
illnesses
dysbiosis
microbial
makeup.
present
understanding
literature
surrounding
relationship
between
intestinal
emergence
certain
diseases,
such
as
Alzheimer's
disease,
Parkinson's
Huntington's
multiple
sclerosis,
main
emphasis
review.
potential
entry
pathway
pathogen-associated
secretions
toxins
into
CNS
explored
article
at
outset
neuropathology.
We
have
included
possible
undelaying
synergistic
effect
infections,
their
metabolites,
interactions
based
on
current
understanding.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(5), P. 949 - 949
Published: Feb. 23, 2022
The
intestinal
barrier,
composed
of
the
luminal
microbiota,
mucus
layer,
and
physical
barrier
consisting
epithelial
cells
immune
cells,
latter
residing
underneath
within
plays
a
special
role
in
health
disease.
While
there
is
growing
knowledge
on
changes
to
different
layers
associated
with
disease
development,
function
also
an
important
during
aging.
Besides
composition
cellular
junctions,
entire
gastrointestinal
physiology
contributes
essential
age-related
changes.
This
reflected
by
substantial
differences
microbial
throughout
life
span.
Even
though
it
remains
difficult
define
physiological
distinguish
them
from
early
signs
pathologies,
studies
centenarians
provide
insights
into
features
longevity.
reviewed
this
narrative
review
article
might
contribute
definition
strategies
prevent
development
diseases
elderly.
Thus,
targeted
interventions
improve
overall
will
be
prevention
for
healthy
aging
future.
Neural Regeneration Research,
Journal Year:
2022,
Volume and Issue:
17(11), P. 2407 - 2407
Published: Jan. 1, 2022
Recent
emerging
research
on
intestinal
microbiota
and
its
contribution
to
the
central
nervous
system
during
health
disease
has
attracted
significant
attention.
Age-related
changes
initiate
brain
aging
age-related
neurodegenerative
disorders.
Aging
is
one
of
critical
predisposing
risk
factors
for
development
diseases.
Maintaining
a
healthy
gut
essential
body
aging,
but
dysbiosis
could
many
chronic
Understanding
underlying
mechanisms
alterations/dysbiosis
will
help
identify
biomarkers
aging-related
conditions.
This
review
summarizes
recent
advances
in
microbiota-neurodegenerative
enhance
our
understanding
effects
aging.
Aging Cell,
Journal Year:
2022,
Volume and Issue:
21(9)
Published: Aug. 5, 2022
Abstract
Stem
cell
senescence
is
an
important
cause
of
aging.
Delaying
may
present
a
novel
way
to
combat
aging
and
age‐associated
diseases.
This
study
provided
mechanistic
insight
into
the
protective
effect
ganoderic
acid
D
(GA‐D)
against
human
amniotic
mesenchymal
stem
(hAMSCs)
senescence.
GA‐D,
Ganoderma
lucidum
‐derived
triterpenoid,
markedly
prevented
hAMSCs
via
activating
Ca
2+
calmodulin
(CaM)/CaM‐dependent
protein
kinase
II
(CaMKII)/nuclear
erythroid
2‐related
factor
2
(Nrf2)
axis,
14‐3‐3ε
was
identified
as
target
GA‐D.
14‐3‐3ε‐encoding
gene
(
YWHAE
)
knockdown
in
reversed
activation
CaM/CaMKII/Nrf2
signals
attenuate
GA‐D
anti‐aging
increase
senescence‐associated
β
‐galactosidase
(SA‐
‐gal),
p16
p21
expression
levels,
including
reactive
oxygen
species
(ROS)
production,
thereby
promoting
cycle
arrest
decreasing
differentiation
potential.
overexpression
maintained
or
slightly
enhanced
effect.
d
‐galactose‐caused
mice
by
significantly
increasing
total
antioxidant
capacity,
well
superoxide
dismutase
glutathione
peroxidase
activity,
reducing
formation
malondialdehyde,
advanced
glycation
end
products,
receptor
products.
Consistent
with
mechanism
senescence,
delayed
bone‐marrow
cells
this
model
vivo,
reduced
SA‐
‐gal
ROS
alleviated
arrest,
viability
regulating
axis.
Therefore,
retards
targeting
activate
signaling
pathway.
Furthermore,
vivo
involve
regulation
same
signal
FEBS Journal,
Journal Year:
2022,
Volume and Issue:
290(17), P. 4163 - 4186
Published: June 21, 2022
Obesity
and
ageing
predispose
to
numerous,
yet
overlapping
chronic
diseases.
For
example,
metabolic
abnormalities,
including
insulin
resistance
(IR)
type
2
diabetes
(T2D)
are
important
causes
of
morbidity
mortality.
Low‐grade
inflammation
tissues,
such
as
the
liver,
visceral
adipose
tissue
neurological
is
considered
a
significant
contributor
these
Thus,
it
becoming
increasingly
understand
what
drives
this
in
affected
tissues.
Recent
evidence,
especially
context
obesity,
suggests
that
intestine
plays
an
role
gatekeeper
inflammatory
stimuli
ultimately
fuels
low‐grade
inflammation.
In
addition
diseases,
abnormalities
intestinal
mucosal
barrier
have
been
linked
range
other
conditions,
neurodegeneration
ageing.
The
flow
from
gut
part
controlled
by
local
immunological
inputs
impacting
barrier.
Here,
we
will
review
impact
obesity
on
immune
system
its
downstream
consequences
function,
which
strongly
implicated
pathogenesis
age‐related
particular,
discuss
effects
dysfunction
neurodegenerative
