The contribution of circadian clock to the biological processes

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: June 6, 2024

All organisms have various circadian, behavioral, and physiological 24-h periodic rhythms, which are controlled by the circadian clock. The clock controls behavioral rhythms. In mammals, primary is present in suprachiasmatic nucleus of hypothalamus. rhythm interaction between negative positive feedback loops, consisting crucial regulators (including Bmal1 Clock), three cycles (mPer1, mPer2, mPer3), two cryptochromes (Cry1 Cry2). development early mammalian embryos an ordered complex biological process that includes stages from fertilized eggs to blastocysts undergoes important morphological changes, such as blastocyst formation, cell multiplication, compaction. affects onset timing embryonic development. many processes, including eating time, immune function, sleep, energy metabolism, endocrinology, therefore, it also for overall health, growth after birth. This review summarized effects body's activities. A new strategy proposed prevention malformations or diseases regulating changing

Language: Английский

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The circadian rhythm: A new target of natural products that can protect against diseases of the metabolic system, cardiovascular system, and nervous system

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

The treatment of metabolic system, cardiovascular and nervous system diseases remains to be explored. In the internal environment organisms, metabolism substances such as carbohydrates, lipids proteins (including biohormones enzymes) exhibit a certain circadian rhythm maintain energy supply material cycle needed for normal activities organisms. As key factor health can disrupted by pathological conditions, this disruption accelerates progression results in vicious cycle. current treatments targeting have limitations, identification safer more effective regulators is needed. To systematically assess possibility using biological clock natural product target disease intervention, work reviews range evidence on potential effectiveness products protect against system. This manuscript focuses how restore function affecting amplitude expression factors, sleep/wake cycles structure gut microbiota. proposes that rhythm, which regulated rhythm-related factors cycle, crucial new slowing through use products. provides reference molecular modeling perspective time-targeted action drugs.

Language: Английский

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Falling Asleep on the Job: The Efficacy of a Short App‐Based Mindfulness Intervention to Improve Sleep Quality and Quantity Within the Workforce

Stress and Health, Journal Year: 2025, Volume and Issue: 41(1)

Published: Feb. 1, 2025

ABSTRACT Quality sleep is among the most important determinants of psychological and physical well‐being. Insufficient quality quantity directly affect individuals; in turn, they indirectly productivity, viability safety workplaces. Sleep issues also represent a global health concern for people workplaces around world. In addition to pharmaceutical aids, effective accessible interventions need address underlying problems, as might be achieved by behavioural therapies or structured, cognitive like mindfulness‐based programs. The time intensity relatively high costs such tactics has limited their widespread adoption though. With sample 606 full‐time working adults, current study tests potential effectiveness short, inexpensive, app‐based, self‐help mindfulness meditation programme promoting quantity. Using longitudinal randomised experimental design, authors compared utility 10‐day with passive control group, well an active group that engaged 10 days mind‐wandering exercises. benefits emerged immediately after intervention but seemingly wore off about three months later. Acknowledging interactions between sleep, depression anxiety, we measured two latter variables. We find was on depression, not anxiety. These insights offer implications both research practice.

Language: Английский

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Crosstalk Between Aging, Circadian Rhythm, and Melatonin

Rejuvenation Research, Journal Year: 2023, Volume and Issue: 26(6), P. 229 - 241

Published: Oct. 17, 2023

Circadian rhythms (CRs) are 24-hour periodic oscillations governed by an endogenous circadian pacemaker located in the suprachiasmatic nucleus (SCN), which organizes physiology and behavior of organisms. rhythm disruption (CRD) is also indicative aging process. In mammals, melatonin primarily synthesized pineal gland participates a variety multifaceted intracellular signaling networks has been shown to synchronize CRs. Endogenous synthesis its release tend decrease progressively with advancing age. Older individuals experience frequent CR disruption, hastens process aging. A profound understanding relationship between CRs potential improve existing treatments facilitate development novel chronotherapies that target age-related disorders. This review article aims examine regulatory mechanisms plays key role signaling. We describe basic architecture molecular clock functional decline age detail. Furthermore, we discuss regulation redox homeostasis during Moreover, protective effect exogenous supplementation age-dependent sheds light on this pleiotropic molecule how it can be used as effective chronotherapeutic medicine.

Language: Английский

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A single-cell transcriptomic atlas of the prefrontal cortex across the human lifespan

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract The dorsolateral prefrontal cortex is central to higher cognitive functions and particularly vulnerable age-related decline. To advance our understanding of the molecular mechanisms underlying brain development, maturation, aging, we constructed a detailed single-cell transcriptomic atlas human cortex, encompassing over 1.3 million nuclei from 284 postmortem samples spanning full lifespan (0-97 years). This reveals distinct phases activity: dynamic developmental period, stabilization during midlife, subtle yet coordinated changes in late adulthood. Modeling non-linear age trends across shows ten trajectories entire transcriptome all cell types, with notable findings neurons microglia, linked neurodevelopmental disorders Alzheimer’s disease risk, respectively. Moreover, excitatory exhibit convergence gene expression patterns lifespan, suggesting emergence common signature aging. Pseudotime analysis tracing progression cellular lineages throughout life key clusters that reflect as well their connection brain-related diseases. We uncover significant circadian rhythm reprogramming adulthood, characterized by disruption core clock rhythmicity new rhythmic patterns, within microglia oligodendrocytes. comprehensive provides baseline for transitions development through successful aging cortex.

Language: Английский

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Prospective analysis of sleep characteristics, chronotype, and risk of breast cancer in the california teachers study

Cancer Causes & Control, Journal Year: 2023, Volume and Issue: 35(4), P. 597 - 604

Published: Nov. 9, 2023

Abstract Purpose Poor sleep quality and evening chronotype were associated with increased risk of breast cancer in a previous retrospective study the California Teachers Study (CTS). The present analysis examines these factors prospectively same cohort women. Methods From CTS, we included 1,085 incident cases 38,470 cancer-free participants from 2012 through 2019. We calculated time at used Cox proportional hazards regression models to estimate hazard ratios (HRs) control for such as age, race, body mass index, family history cancer, reproductive history. examined quality, latency, duration, disturbance, medication use, based on shortened version Pittsburgh Sleep Quality Index, well (preference morning or activity). This was limited women who post-menopausal they answered sleep-related questions. Results Measures did not appear be subsequent risk. HR chronotypes compared somewhat elevated (HR 1.19, 95% CI 1.04, 1.36). Conclusion While measures duration this prospective analysis, modestly observed consistent prior analysis.

Language: Английский

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Association of sleep duration, chronotype, social jetlag, and sleep disturbance with phenotypic age acceleration: A cross-sectional analysis

Sleep Health, Journal Year: 2024, Volume and Issue: 10(1), P. 122 - 128

Published: Jan. 21, 2024

Language: Английский

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Chronic Astrocytic TNFα Production in the Preoptic-Basal Forebrain Causes Aging-like Sleep–Wake Disturbances in Young Mice

Cells, Journal Year: 2024, Volume and Issue: 13(11), P. 894 - 894

Published: May 22, 2024

Sleep disruption is a frequent problem of advancing age, often accompanied by low-grade chronic central and peripheral inflammation. We examined whether neuroinflammation in the preoptic basal forebrain area (POA-BF), critical sleep-wake regulatory structure, contributes to this disruption. developed targeted viral vector designed overexpress tumor necrosis factor-alpha (TNFα), specifically astrocytes (AAV5-GFAP-TNFα-mCherry), injected it into POA young mice induce heightened within POA-BF. Compared control (treated with AAV5-GFAP-mCherry), astrocytic TNFα overproduction POA-BF exhibited signs increased microglia activation, indicating local inflammatory milieu. These also aging-like changes organization physical performance, including (a) impaired functions characterized disruptions sleep waking during light dark phases, respectively, reduced ability compensate for loss; (b) dysfunctional VLPO sleep-active neurons, indicated fewer neurons expressing c-fos after suvorexant-induced sleep; (c) compromised performance as demonstrated decline grip strength. findings suggest that inflammation-induced dysfunction sleep- wake-regulatory mechanisms may be component disturbances aging.

Language: Английский

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Mutational Signatures in Gastric Cancer and Their Clinical Implications

Cancers, Journal Year: 2023, Volume and Issue: 15(15), P. 3788 - 3788

Published: July 26, 2023

Gastric cancer is characterised by high inter- and intratumour heterogeneity. The majority of patients are older than 65 years the global burden this disease increasing due to aging population. usually diagnosed at advanced stages, which a consequence nonspecific symptoms. Few improvements have been made level noninvasive molecular diagnosis sporadic gastric cancer, therefore mortality rate remains high. A new field mutational signatures has emerged in past decade with advances genome sequencing technology. These distinct patterns genome, caused exogenous endogenous processes, can be associated tumour aetiology progression, could provide novel perception on treatment possibilities. This review assesses found summarises their potential for use clinical setting as diagnostic or prognostic biomarkers. Associated options biomarkers already implemented discussed, together those that still being explored studies.

Language: Английский

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Circadian disruption does not alter tumorigenesis in a mouse model of lymphoma

F1000Research, Journal Year: 2023, Volume and Issue: 12, P. 49 - 49

Published: Sept. 28, 2023

Disruption of natural light cycles, as experienced by shift workers, is linked to enhanced cancer incidence. Several mouse models develop more severe disease when exposed irregular light/dark supporting the connection between circadian disruption and increased risk. Cryptochrome 2 (CRY2), a repressive component molecular clock, facilitates turnover oncoprotein c-MYC, one mechanism that may link clock tumorigenesis. In Eμ-MYC mice, which express transgenic

Language: Английский

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