Light, lighting and human health DOI
P.R. Boyce

Lighting Research & Technology, Journal Year: 2021, Volume and Issue: 54(2), P. 101 - 144

Published: April 28, 2021

Light can impact human health via the visual and non-visual systems originating in retina of eye or as optical radiation falling on skin. This paper provides a summary what is known about these impacts. Topics covered include aspects lighting likely to cause eyestrain headaches; increase risk falls; induce circadian disruption; enhance sleep; mitigate Alzheimer’s disease depression; produce tissue damage; alleviate diseases through phototherapy inactivate viruses germicidal irradiation. It concluded that undoubtedly influenced by lighting, but there are four conditions should be attached such simple assertion. First, either positive negative. Second, affected many factors other than lighting. Third, severity effects light exposure vary widely from short-lived trivial long-term fatal. Fourth, same have very different impacts for individuals depending their age medical status. Taken together, imply care required when judging veracity relevance broad assertions benefits health.

Language: Английский

Rhythms of life: circadian disruption and brain disorders across the lifespan DOI Open Access
Ryan W. Logan, Colleen A. McClung

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 20(1), P. 49 - 65

Published: Nov. 20, 2018

Language: Английский

Citations

532
Measuring sleep quality in older adults: a comparison using subjective and objective methods DOI Creative Commons
Glenn J. Landry, John R. Best, Teresa Liu‐Ambrose

et al.

Frontiers in Aging Neuroscience, Journal Year: 2015, Volume and Issue: 7

Published: Sept. 7, 2015

Sleep quality decreases with aging and thus sleep complaints are prevalent in older adults, particularly for those cognitive impairment dementia. For emerging evidence suggests poor increases risk of developing Given the population – impending economic burden associated increasing numbers dementia patients there is pressing need to improve among adults. As such, research efforts have increased focus on investigating association between age-related changes decline a complex construct evaluate empirically, yet Pittsburg Quality Index (PSQI) commonly used studies as their only measure quality. Furthermore, PSQI may not be best due its reliance capacity reflect past month. Further study needed determine PSQI's validity Thus, current examined 78 community dwelling adults 55+ predictive objective (as measured by actigraphy). We compared two subjective measures Consensus Diary (CSD) actigraphy (MotionWatch 8; camntech). Our results suggest perceived quite different from reality, at least 55+. Importantly, we show this difference unrelated age, gender, education, or status (assessed using standard screens). Previous shown valuable tool assessing quality; however, our findings indicate should substitute actigraphy, vice versa. Hence, conclude practice include both when examining (i.e., PSQI, CSD,

Language: Английский

Citations

407
Recommendations for daytime, evening, and nighttime indoor light exposure to best support physiology, sleep, and wakefulness in healthy adults DOI Creative Commons
Timothy M. Brown, George C. Brainard, Christian Cajochen

et al.

PLoS Biology, Journal Year: 2022, Volume and Issue: 20(3), P. e3001571 - e3001571

Published: March 17, 2022

Ocular light exposure has important influences on human health and well-being through modulation of circadian rhythms sleep, as well neuroendocrine cognitive functions. Prevailing patterns do not optimally engage these actions for many individuals, but advances in our understanding the underpinning mechanisms emerging lighting technologies now present opportunities to adjust promote optimal physical mental performance. A newly developed, international standard provides a SI-compliant way quantifying influence intrinsically photosensitive, melanopsin-expressing, retinal neurons that mediate effects. The report recommendations lighting, based an expert scientific consensus expressed easily measured quantity (melanopic equivalent daylight illuminance (melaponic EDI)) defined within this standard. are supported by detailed analysis sensitivity circadian, neuroendocrine, alerting responses ocular provide straightforward framework inform design practice.

Language: Английский

Citations

331
The impact of daytime light exposures on sleep and mood in office workers DOI
Mariana G. Figueiro,

Bryan Steverson,

Judith Heerwagen

et al.

Sleep Health, Journal Year: 2017, Volume and Issue: 3(3), P. 204 - 215

Published: April 23, 2017

Language: Английский

Citations

239
Light as a circadian stimulus for architectural lighting DOI
Mark S. Rea,

MG Figueiro

Lighting Research & Technology, Journal Year: 2016, Volume and Issue: 50(4), P. 497 - 510

Published: Dec. 6, 2016

Consideration is being given to the adoption of a new metric characterizing light as it affects human circadian system. Much has been learned over past couple decades about stimulus for system regulation, so appropriate that these discussions take place. The present paper develops an argument adopting quantifying in architectural spaces. (a) was developed from several lines biophysical research, including those basic retinal neurophysiology; (b) validated controlled experiments; and (c) used successfully number real-world applications. Any metrics should each foundational points into consideration.

Language: Английский

Citations

228
Time-restricted Eating for the Prevention and Management of Metabolic Diseases DOI Open Access
Emily N. C. Manoogian, Lisa S. Chow, Pam R. Taub

et al.

Endocrine Reviews, Journal Year: 2021, Volume and Issue: 43(2), P. 405 - 436

Published: Sept. 22, 2021

Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE, humans) are an emerging behavioral intervention approach based on the understanding of role circadian rhythms in physiology metabolism. In this approach, all calorie intake is restricted within a consistent interval less than 12 hours without overtly attempting to reduce calories. This article will summarize origin TRF/TRE starting with concept chronic rhythm disruption increasing risk for metabolic diseases. Circadian usually perceived as sleep-wake cycle dependent arising from central nervous system. However, recent discovery peripheral organs plasticity these response changes nutrition availability raised possibility that adopting daily short window can sustain robust rhythm. Preclinical animal studies have demonstrated proof identified potential mechanisms driving TRF-related benefits. Pilot human reported promising results reducing obesity, diabetes, cardiovascular Epidemiological indicated maintaining long overnight fast, which similar TRE, significantly risks Despite early successes, more clinical mechanistic needed implement TRE alone or adjuvant lifestyle prevention management

Language: Английский

Citations

208
The inner clock—Blue light sets the human rhythm DOI
Siegfried Wahl,

Moritz Engelhardt,

Patrick Schaupp

et al.

Journal of Biophotonics, Journal Year: 2019, Volume and Issue: 12(12)

Published: Aug. 21, 2019

Visible light synchronizes the human biological clock in suprachiasmatic nuclei of hypothalamus to solar 24-hour cycle. Short wavelengths, perceived as blue color, are strongest synchronizing agent for circadian system that keeps most and psychological rhythms internally synchronized. Circadian rhythm is important optimum function organisms sleep-wake disruptions or chronic misalignment often may lead psychiatric neurodegenerative illness. The beneficial effect on synchronization, sleep quality, mood, cognitive performance depends not only spectral composition but also timing exposure its intensity. Exposure during day suppress melatonin secretion, hormone produced by pineal gland plays crucial role entrainment. While keeping organism's wellbeing, alertness, day, low-intensity directly before bedtime, have serious implications phase cycle durations. This rises inevitably need solutions improve today's modern society where emitting devices ever increasing.

Language: Английский

Citations

206
Intrinsically Photosensitive Retinal Ganglion Cells of the Human Retina DOI Creative Commons
Ludovic S. Mure

Frontiers in Neurology, Journal Year: 2021, Volume and Issue: 12

Published: March 25, 2021

Light profoundly affects our mental and physical health. In particular, light, when not delivered at the appropriate time, may have detrimental effects. mammals, light is perceived only by rods cones but also a subset of retinal ganglion cells that express photopigment melanopsin renders them intrinsically photosensitive (ipRGCs). ipRGCs participate in contrast detection play critical roles non-image-forming vision, set responses include circadian entrainment, pupillary reflex (PLR), modulation sleep/alertness, mood. are found human retina, their response to has been characterized indirectly through suppression nocturnal melatonin PLR. However, until recently, had rarely investigated directly. This gap progressively being filled as, over last years, an increasing number studies provided descriptions morphology, gene expression. Here, I review progress knowledge ipRGCs, different morphological functional subtypes described so far how they match murine subtypes. highlight questions remain be addressed. Investigating as these few major role well-being. Additionally, display increased vulnerability or resilience certain disorders compared conventional RGCs, deeper function could help identify therapeutic approaches develop diagnostic tools. Overall, better understanding eye will deliver precise usage recommendations implement light-based interventions improve cognitive performance, mood, life quality.

Language: Английский

Citations

107
New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases DOI Creative Commons
Yujie Sun,

Qiankun Lv,

Junyi Liu

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: 205, P. 106791 - 106791

Published: Jan. 6, 2025

Neurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial (ISF), facilitates movement metabolic substances within brain, serving functions akin to those peripheral lymphatic system. This emerging waste clearance mechanism offers a novel perspective on removal pathological in ND. article elucidates recent discoveries regarding system updates relevant concepts model. It discusses potential roles ND, including Alzheimer's disease (AD), Parkinson's (PD), multiple atrophy (MSA), proposes as therapeutic target for these conditions.

Language: Английский

Citations

2
Endocrine Effects of Circadian Disruption DOI Open Access
Tracy A. Bedrosian, Laura K. Fonken, Randy J. Nelson

et al.

Annual Review of Physiology, Journal Year: 2015, Volume and Issue: 78(1), P. 109 - 131

Published: July 25, 2015

Disruption of circadian rhythms, provoked by artificial lighting at night, inconsistent sleep-wake schedules, and transmeridian air travel, is increasingly prevalent in modern society. Desynchrony biological rhythms from environmental light cycles has dramatic consequences for human health. In particular, disrupting homeostatic oscillations endocrine tissues the hormones that these regulate can have cascading effects on physiology behavior. Accumulating evidence suggests chronic disruption organization function may lead to metabolic, reproductive, sleep, mood disorders. This review discusses control systems distorting rhythmicity systems.

Language: Английский

Citations

150