The role of insufficient sleep and circadian misalignment in obesity

Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 19(2), P. 82 - 97

Published: Oct. 24, 2022

Language: Английский

---

Circadian rhythms and disorders of the timing of sleep

The Lancet, Journal Year: 2022, Volume and Issue: 400(10357), P. 1061 - 1078

Published: Sept. 1, 2022

Language: Английский

---

Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements

Nutrients, Journal Year: 2022, Volume and Issue: 14(19), P. 3934 - 3934

Published: Sept. 22, 2022

Melatonin has become a popular dietary supplement, most known as chronobiotic, and for establishing healthy sleep. Research over the last decade into cancer, Alzheimer’s disease, multiple sclerosis, fertility, PCOS, many other conditions, combined with COVID-19 pandemic, led to greater awareness of melatonin because its ability act potent antioxidant, immune-active agent, mitochondrial regulator. There are distinct similarities between vitamin D in depth breadth their impact on health. Both hormones, affect systems through immune-modulating, anti-inflammatory functions, found skin, responsive sunlight darkness. In fact, there may be widespread concern about deficiency “sunlight deficiency” reduced secretion result “darkness from overexposure artificial blue light. The trend toward use supplements resulted safety, especially higher doses, long-term use, application certain populations (e.g., children). This review aims evaluate recent data melatonin’s mechanisms, clinical uses beyond sleep, safety concerns, thorough summary therapeutic considerations concerning supplementation, including different formats available (animal, synthetic, phytomelatonin), dosing, timing, contraindications, nutrient combinations.

Language: Английский

---

Reducing nighttime light exposure in the urban environment to benefit human health and society

Science, Journal Year: 2023, Volume and Issue: 380(6650), P. 1130 - 1135

Published: June 15, 2023

Nocturnal light pollution can have profound effects on humans and other organisms. Recent research indicates that nighttime outdoor lighting is increasing rapidly. Evidence from controlled laboratory studies demonstrates nocturnal exposure strain the visual system, disrupt circadian physiology, suppress melatonin secretion, impair sleep. There a growing body of work pointing to adverse human health, including risk chronic diseases, but this knowledge in more nascent stage. In Review, we synthesize recent context-specific factors physiology relevant relation health society, identify critical areas for future research, highlight policy steps recommendations mitigating urban environment.

Language: Английский

---

The sleep–circadian interface: A window into mental disorders

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(9)

Published: Feb. 23, 2024

Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the quality, continuity, timing of sleep can precipitate or exacerbate psychiatric symptoms in susceptible individuals, while treatments that target sleep-circadian disturbances alleviate psychopathology. Conversely, poor disrupt clock-controlled processes. Despite progress elucidating underlying mechanisms, a cohesive approach integrates dynamic interactions between disorder with both processes is lacking. This review synthesizes recent evidence for dysfunction as transdiagnostic contributor range disorders, an emphasis on biological mechanisms. We highlight observations from adolescent young adults, who at greatest risk developing whom early detection intervention promise benefit. In particular, we aim a) integrate factors implicated pathophysiology treatment mood, anxiety, psychosis spectrum perspective; b) need reframe existing knowledge adopt integrated which recognizes interaction factors; c) identify important gaps opportunities further research.

Language: Английский

---

Circadian Rhythms, Chrononutrition, Physical Training, and Redox Homeostasis—Molecular Mechanisms in Human Health

Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 138 - 138

Published: Jan. 11, 2024

A multitude of physiological processes, human behavioral patterns, and social interactions are intricately governed by the complex interplay between external circumstances endogenous circadian rhythms. This multidimensional regulatory framework is susceptible to disruptions, in contemporary society, there a prevalent occurrence misalignments system environmental cues, phenomenon frequently associated with adverse health consequences. The onset most current chronic diseases intimately connected alterations lifestyle practices under various facets, including following: reduced physical activity, exposure artificial light, also acknowledged as light pollution, sedentary behavior coupled consuming energy-dense nutriments, irregular eating frameworks, disruptions sleep patterns (inadequate quality duration), engagement shift work, known jetlag. rapid evolution life domestic routines has significantly outpaced rate genetic adaptation. Consequently, underlying rhythms exposed multiple shifts, thereby elevating susceptibility disease predisposition. comprehensive review endeavors synthesize existing empirical evidence that substantiates conceptual integration clock, biochemical molecular homeostasis, oxidative stress, stimuli imparted exercise, sleep, nutrition.

Language: Английский

---

Higher vulnerability to poor circadian light hygiene in individuals with a history of COVID-19

Chronobiology International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: Jan. 6, 2025

Seven-day actigraphy was performed within 1 month in 122 community-dwelling adults (mean age 24.40 y, 31 (25.4%) men) the same city of Tyumen, Russia. Groups with different COVID-19 status (present, COVID-19(+),

Language: Английский

---

Human-Centric Lighting: Foundational Considerations and a Five-Step Design Process

Frontiers in Neurology, Journal Year: 2021, Volume and Issue: 12

Published: Jan. 27, 2021

At its best, human-centric lighting considers the visual and non-visual effects of light in support positive human outcomes. worst, it is a marketing phrase used to healthwash products or design solutions. There no doubt that environmental contributes health, but how might one practice given both credible potential implausible hype? Marketing literature filled with promises. Technical societies have summarized science not yet offered guidance. Meanwhile, designers are middle, attempting distinguish knowledge from which dubious make decisions affect people directly. This article intended to: (1) empower reader fundamental understandings ways affects health; (2) provide process for can dovetail decision-making already part designer's workflow.

Language: Английский

---

Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement

American Journal of Respiratory and Critical Care Medicine, Journal Year: 2023, Volume and Issue: 207(7), P. e49 - e68

Published: March 31, 2023

Section:ChooseTop of pageAbstract <

Language: Английский

---

Associations between light exposure and sleep timing and sleepiness while awake in a sample of UK adults in everyday life

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(42)

Published: Oct. 9, 2023

Experimental and interventional studies show that light can regulate sleep timing sleepiness while awake by setting the phase of circadian rhythms supporting alertness. The extent to which differences in exposure explain variations within between individuals everyday life remains less clear. Here, we establish a method address this deficit, incorporating an open-source wearable wrist-worn logger (SpectraWear) smartphone-based online data collection. We use it simultaneously record longitudinal (in melanopic equivalent daylight illuminance), timing, subjective alertness over seven days convenience sample 59 UK adults without externally imposed challenge (e.g., shift work or jetlag). Participants reliably had strong daily but frequently were exposed during daytime more pre-bedtime episodes than recommended [T. M. Brown et al. , PLoS Biol. 20 e3001571 (2022)]. Prior several hours was associated with lower with, particular, brighter late episode after wake linked reduced early morning (sleep inertia). Higher longer onset latency. Early correlated reproducible robust patterns higher daytime/lower night-time exposure. Our study establishes for collecting health/performance provides evidence associations important determinants health performance.

Language: Английский

---