Incidence and genetic risk of juvenile idiopathic arthritis in Norway by latitude DOI Creative Commons
Sigrid Hestetun, Hamid Khoshfekr Rudsari, Piotr Jahołkowski

et al.

Arthritis & Rheumatology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Objective We aimed to investigate the incidence of juvenile idiopathic arthritis (JIA) in three geographic regions Norway and whether potential regional differences are explained by environmental or genetic factors across regions. Methods conducted a register‐based cohort study including all Norwegian children born from 2004 2019, with follow‐up throughout 2020. The JIA diagnosis, defined at least two International Classification Diseases, Tenth Revision codes for JIA, was validated against medical records. rate (IR) hazard ratio (HR) were estimated North, Mid, South In subsample Mother, Father, Child Cohort Study (MoBa), risk assessed Results After median 9.1 (range 0.3–16.0) years follow‐up, we identified 1,184 patients 910,058 controls. IR JIA/100,000 person‐years 14.4 Norway, 25.9 North region, 17.9 Mid 12.5 region. HR (95% confidence interval [CI]) region 2.07 (1.77–2.43) 1.43 CI 1.23–1.67) compared Adjustments perinatal factors, socioeconomic status, early antibiotic exposure did not change our estimates substantially. MoBa (238 57,392 controls), association between birth no longer significant when adjusting factors. Conclusion found higher increasing latitude without evidence available explaining observed gradient. contrast, modified association, but further studies warranted.

Language: Английский

New Surgery and Hospital-diagnosed Infections in Elderly Patients with Inflammatory Bowel Disease Undergoing Surgery: A Nationwide Cohort Study DOI
Bente Mertz Nørgård, Olav Sivertsen Garvik, Floor Dijkstra Zegers

et al.

Journal of Crohn s and Colitis, Journal Year: 2024, Volume and Issue: 18(9), P. 1406 - 1414

Published: April 4, 2024

Abstract Background Elderly patients with inflammatory bowel disease [IBD] are fragile in many respects. Therefore, these patients, we studied postoperative complications [new abdominal surgery and serious infections after the first IBD surgery]. Methods This is a nationwide cohort study based on Danish health registries included undergoing surgery. The population was split into ulcerative colitis [UC] Crohn’s [CD]. exposed [elderly] constituted those at an age of ≥60 years surgery, unexposed [adults] 18–59 years. We estimated adjusted hazard ratios [aHRs] of: a] new within 2 years; b] [hospital-diagnosed] 6 12 months. for several confounders including type index [laparoscopic or open]. Results aHR among elderly UC CD were 0.69 [95% CI 0.58-0.83] 0.98 0.83-1.15], respectively. In UC, aHRs months 1.07 0.81-1.40] 0.85 0.67-1.08], CD, 1.45 1.12-1.88] 1.26 1.00-1.59], Conclusion did not have increased risk but had

Language: Английский

Citations

1
Breastfeeding Duration Is Not Associated With Offspring Inflammatory Bowel Disease Risk in Three Population-Based Birth Cohorts DOI Creative Commons
Manasi Agrawal,

Ketil Størdal,

Anne Vinkel Hansen

et al.

Clinical Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: 22(12), P. 2459 - 2467.e16

Published: May 9, 2024

Breastfeeding is critical for offspring health and development. Although many observational studies report a protective effect between breastfeeding inflammatory bowel disease (IBD), the relationship not well-understood.

Language: Английский

Citations

1
The validity of pathology codes for biopsy-confirmed kidney disease in the Danish National Patobank DOI Creative Commons

Marie Møller,

Iain Bressendorff, Rikke Borg

et al.

Clinical Kidney Journal, Journal Year: 2024, Volume and Issue: 17(8)

Published: July 9, 2024

ABSTRACT Background This study validates the application of Systematized Nomenclature Medicine second edition (SNOMED II) codes used to describe medical kidney biopsies in Denmark encoded form, aiming support robust epidemiological research on causes, treatments and prognosis diseases. Methods Kidney biopsy reports from 1 January 1998 31 December 2018 were randomly extracted Danish National Patobank, using SNOMED codes. A 5% sample was selected, nephrologists assessed corresponding records, assigning each case applied clinical diagnoses. Sensitivity, specificity, positive predictive values (PPV), negative Cohen's kappa coefficient for retrieved calculated. Results total 613 included. The primary disease groups glomerular (n = 368), tubulointerstitial 67), renal vascular 51), diabetic nephropathy 51) various disorders 40). Several group PPV combined high (94%), (85%) systemic diseases affecting (96%). Conversely, (62%), (60%) other (17%) showed lower PPV. Conclusions have a diseases, kidney, which they could be future research.

Language: Английский

Citations

1
Screening participants with inflammatory bowel disease or high colorectal cancer risk in Denmark: a cohort study DOI Creative Commons
Signe Bülow Therkildsen, Pernille Thordal Larsen, Sisse Helle Njor

et al.

Journal of Public Health Policy, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Individuals with inflammatory bowel disease (IBC) and high-risk individuals are advised to discuss participation their doctor not participate in colorectal cancer (CRC) screening. Yet a substantial proportion still the Danish faecal immunochemical test (FIT) screening have higher positive FIT rate than average-risk population. We estimated risk of false-positive among improve recommendations regarding participation. included 71,871 FIT-positive participants (2014–2017) who had subsequent colonoscopy within 3 months. Screening outcome 180 days was established by using registers. determined that 26,591 Participants IBC or high CRC significantly getting average population, resulting too many screening-related colonoscopies being performed these individuals, indicating need update protocols.

Language: Английский

Citations

1
Incidence and genetic risk of juvenile idiopathic arthritis in Norway by latitude DOI Creative Commons
Sigrid Hestetun, Hamid Khoshfekr Rudsari, Piotr Jahołkowski

et al.

Arthritis & Rheumatology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Objective We aimed to investigate the incidence of juvenile idiopathic arthritis (JIA) in three geographic regions Norway and whether potential regional differences are explained by environmental or genetic factors across regions. Methods conducted a register‐based cohort study including all Norwegian children born from 2004 2019, with follow‐up throughout 2020. The JIA diagnosis, defined at least two International Classification Diseases, Tenth Revision codes for JIA, was validated against medical records. rate (IR) hazard ratio (HR) were estimated North, Mid, South In subsample Mother, Father, Child Cohort Study (MoBa), risk assessed Results After median 9.1 (range 0.3–16.0) years follow‐up, we identified 1,184 patients 910,058 controls. IR JIA/100,000 person‐years 14.4 Norway, 25.9 North region, 17.9 Mid 12.5 region. HR (95% confidence interval [CI]) region 2.07 (1.77–2.43) 1.43 CI 1.23–1.67) compared Adjustments perinatal factors, socioeconomic status, early antibiotic exposure did not change our estimates substantially. MoBa (238 57,392 controls), association between birth no longer significant when adjusting factors. Conclusion found higher increasing latitude without evidence available explaining observed gradient. contrast, modified association, but further studies warranted.

Language: Английский

Citations

1