Identification and exploration of anticancer activity of novel peptides isolated from the edible bivalve Callista chione in hepatic and colon cancer cell lines

Toxicology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 101915 - 101915

Published: Jan. 1, 2025

Language: Английский

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Electrospun Magnetic Nanofiber Mats for Magnetic Hyperthermia in Cancer Treatment Applications—Technology, Mechanism, and Materials

Polymers, Journal Year: 2023, Volume and Issue: 15(8), P. 1902 - 1902

Published: April 15, 2023

The number of cancer patients is rapidly increasing worldwide. Among the leading causes human death, can be regarded as one major threats to humans. Although many new treatment procedures such chemotherapy, radiotherapy, and surgical methods are nowadays being developed used for testing purposes, results show limited efficiency high toxicity, even if they have potential damage cells in process. In contrast, magnetic hyperthermia a field that originated from use nanomaterials, which, due their properties other characteristics, clinical trials solutions treatment. Magnetic nanomaterials increase temperature nanoparticles located tumor tissue by applying an alternating field. A very simple, inexpensive, environmentally friendly method fabrication various types functional nanostructures adding additives spinning solution electrospinning process, which overcome limitations this challenging Here, we review recently electrospun nanofiber mats support therapy, targeted drug delivery, diagnostic therapeutic tools, techniques

Language: Английский

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α‐Fe₂O₃@Ag and Fe₃O₄@Ag Core‐Shell Nanoparticles: Green Synthesis, Magnetic Properties and Cytotoxic Performance

ChemistryOpen, Journal Year: 2023, Volume and Issue: 12(6)

Published: June 1, 2023

This work provides the synthetic route for arrangement of Fe

Language: Английский

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Selenium Modification of Natural Products and Its Research Progress

Foods, Journal Year: 2023, Volume and Issue: 12(20), P. 3773 - 3773

Published: Oct. 13, 2023

The selenization of natural products refers to the chemical modification method artificially introducing selenium atoms into interact with functional groups in target molecule form selenides. Nowadays, even though scientists fields involving organic compounds have achieved numerous results due their continuous investment, few comprehensive and systematic summaries relating research can be found. present paper summarizes methods several kinds important products, such as polysaccharides, proteins/polypeptides, polyphenols, lipids, cyclic compounds, well basic principles or mechanisms selenizing methods. On this basis, explored future development trend field selenized it is hoped provide some suggestions for directional application active ingredients.

Language: Английский

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The effect of initial temperature on the mechanical interaction of 3DN5/5OTF protein-based structures using molecular dynamics simulation

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 231, P. 123235 - 123235

Published: Jan. 11, 2023

Language: Английский

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Synthesis and Characterization of Supermagnetic Nanocomposites Coated with Pluronic F127 as a Contrast Agent for Biomedical Applications

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 740 - 740

Published: Feb. 23, 2023

Nanomedicine has garnered significant interest owing to advances in drug delivery, effectively demonstrated the treatment of certain diseases. Here, smart supermagnetic nanocomposites based on iron oxide nanoparticles (MNPs) coated with Pluronic F127 (F127) were developed for delivery doxorubicin (DOX) tumor tissues. The XRD patterns all samples revealed peaks consistent Fe3O4, as shown by their indices (220), (311), (400), (422), (511), and (440), demonstrating that structure Fe3O4 did not change after coating process. After loading DOX, as-prepared drug-loading efficiency capacity percentages 45 ± 0.10 17 0.58% MNP-F127-2-DOX 65 0.12 13 0.79% MNP-F127-3-DOX, respectively. Moreover, a better DOX release rate was observed under acidic conditions, which may be credited pH sensitivity polymer. In vitro analysis survival approximately 90% HepG2 cells treated PBS MNP-F127-3 nanocomposites. Furthermore, decreased, confirming cellular inhibition. Hence, synthesized showed great promise liver cancer treatment, overcoming limitations traditional therapies.

Language: Английский

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Exogenous Chitosan Nanoparticles Modulated Drought Stress Through Changing Yield, Biochemical Attributes, and Fatty Acid Profile of Common Bean (Phaseolus Vulgaris L.) Cultivars

Gesunde Pflanzen, Journal Year: 2023, Volume and Issue: 75(6), P. 2463 - 2476

Published: Aug. 9, 2023

Language: Английский

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Investigating and comparing the mechanical behavior of multicellular structures made with PLA and ABS under lateral loading

Proceedings of the Institution of Mechanical Engineers Part L Journal of Materials Design and Applications, Journal Year: 2023, Volume and Issue: 237(9), P. 1952 - 1963

Published: March 20, 2023

In this research, multicellular structures using two materials acrylonitrile butadiene styrene and Polylactic Acid in various geometries were investigated. At the beginning of samples with a thickness 1 mm made 3D printers. These subjected to quasi-static loading force-displacement curves extracted for them. Subsequently, LS-DYNA finite element software was used simulate under tested experimental mode simulated. After comparing numerical results ensuring correctness simulations, different states simulated total 6 30 examined. The obtained research showed that increase number cells, amount specific energy absorption increased. It also found square cores, cores each row column corresponds force peaks increases cores.

Language: Английский

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Effect of Eleutheroside E on an MPTP-Induced Parkinson’s Disease Cell Model and Its Mechanism

Molecules, Journal Year: 2023, Volume and Issue: 28(9), P. 3820 - 3820

Published: April 29, 2023

This research investigated the effects of eleutheroside E (EE) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease cell model and its mechanism. Methods: To create a disease, MPTP (2500 μmol/L) was administered to rat adrenal pheochromocytoma cells (PC-12) produce an group. Selegiline (50 had been positive group beforehand. The divided into low-, medium-, high-concentration groups, in which were pretreated with at concentrations 100 μmol/L, 300 500 μmol/L. Next, added separately. CCK-8 method used measure survival rate. Apart from method, mitochondrial membrane potential detection, reactive oxygen species (ROS) other methods also adopted verify effect low, medium, high MPTP-induced model. Western blot analysis detect changes expression intracellular proteins CytC, Nrf2, NQO1 clarify results are as follows. Compared group, rates all increased. medium ROS levels decreased. Moreover, apoptosis rate decreased upregulated. Conclusion: Eleutheroside can improve PC-12 by increasing reducing level (ROS). is regulated proteins.

Language: Английский

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Effect of Silibinin on the Expression of Mir-20b, Bcl2L11, and Erbb2 in Breast Cancer Cell Lines

Molecular Biotechnology, Journal Year: 2023, Volume and Issue: 65(12), P. 1979 - 1990

Published: March 11, 2023

Language: Английский

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