Journal of Inflammation Research,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 6003 - 6021
Published: Dec. 1, 2023
The
maintenance
of
bone
homeostasis
is
dynamically
regulated
by
osteoblast-mediated
formation
and
osteoclast-mediated
resorption.
Abnormal
differentiation
osteoclast
insufficient
osteoblast
production
can
cause
diseases
such
as
osteoporosis.
As
one
the
highly
conserved
catabolic
pathways
in
eukaryotic
cells,
autophagy
plays
an
important
role
maintaining
cell
homeostasis,
stress
injury
repair,
proliferation
differentiation.
Numerous
studies
have
found
that
activity
essential
for
survival,
function
regulation
affect
metabolism
osteoblasts
osteoclasts,
thus
affecting
homeostasis.
Therefore,
using
a
theme,
this
review
outlines
basic
process
autophagy,
relationship
between
summarizes
latest
research
progress
common
autophagic
signaling
osteoclasts.
regulatory
effects
protein
molecules
natural
compounds
on
pathway
osteoclasts
discovered
current
are
summarized
discussed.
This
will
help
to
further
clarify
mechanism
osteoporosis,
understand
propose
new
therapeutic
strategies
ideas
anti-osteoporosis.
International Journal of Nanoscience,
Journal Year:
2023,
Volume and Issue:
22(05)
Published: May 17, 2023
Gardenia
blue
(GB)
is
a
natural
pigment
widely
used
in
textiles
and
food
industries
as
an
eco-friendly
alternative
to
synthetic
dyes
owing
its
safety,
biocompatibility
chemical
stability.
Herein
we
demonstrated
recyclable,
reusable
efficient
catalysis
system
for
the
biosynthesis
of
GB
from
geniposide
using
[Formula:
see
text]-glucosidase
embedded
copper
phosphate
hybrid
nanoflowers.
In
this
study,
promising
text]-glucosidase-secreting
actinomycete
was
isolated
identified
Streptomyces
variabilis
BGPA1.
The
secreted
enzyme
successfully
immobilized
nanoflowers
evidenced
by
scanning
electron
microscopy
(SEM)
Fourier-transform
infrared
spectroscopy
(FTIR)
analysis.
Results
revealed
functionality
prepared
bioconversion
into
genipin
which
interacts
with
glycine
yielding
pigment.
optimum
pH
temperature
were
found
be
6.0
50
∘
C,
respectively.
Interestingly,
text]-glucosidase–copper
retained
up
94%
their
initial
activity
after
15
cycles
repeated
usage,
indicating
remarkable
recyclability
reusability
biocatalytic
system.
This
study
suggests
that
could
potential
candidate
facile
production
GB.
Mediators of Inflammation,
Journal Year:
2023,
Volume and Issue:
2023, P. 1 - 11
Published: May 4, 2023
Ferroptosis
is
a
novel
form
of
programmed
cell
death
characterized
by
the
accumulation
iron-dependent
lipid
peroxides,
which
causes
membrane
injury.
Under
catalysis
iron
ions,
cells
deficient
in
glutathione
peroxidase
(GPX4)
cannot
preserve
balance
oxidative
metabolism,
and
buildup
reactive
oxygen
species
on
lipids
leads
to
death.
An
increasing
body
evidence
suggests
that
ferroptosis
plays
significant
role
development
occurrence
cardiovascular
diseases.
In
this
paper,
we
mainly
elaborated
molecular
mechanisms
regulating
its
impact
disease
lay
groundwork
for
future
studies
prophylaxis
treatment
patient
population.
Journal of Orthopaedic Surgery and Research,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: March 11, 2024
Abstract
Background
Cholesterol
(CHO)
is
an
essential
component
of
the
body.
However,
high
CHO
levels
in
body
can
damage
bone
mass
and
promote
osteoporosis.
accumulation
cause
osteoblast
apoptosis,
which
has
a
negative
effect
on
formation.
The
pathogenesis
osteoporosis
complicate
process
that
includes
oxidative
stress,
endoplasmic
reticulum
(ER)
inflammation.
Geniposide
(GEN)
natural
compound
with
anti-osteoporotic
effect.
roles
GEN
osteopathogenesis
are
still
unclear.
Our
previous
studies
demonstrated
could
reduce
osteoblasts
activation
ER
stress
osteoblasts.
molecular
mechanism
inhibiting
CHO-induced
apoptosis
needs
to
be
further
investigated.
Methods
MC3T3-E1
cells
were
treated
osteogenic
induction
medium
(OIM).
Ethanol-solubilized
cholesterol
(100
µM)
was
used
as
stimulator,
10
µM
25
geniposide
added
for
treatment.
alterations
protein
expression
detected
by
western
blot,
cell
analyzed
flow
cytometer.
Results
promoted
activating
osteoblasts,
while
alleviated
reduced
GLP-1R/ABCA1
pathway.
Inhibition
ABCA1
or
GLP-1R
eliminate
protective
activity
against
apoptosis.
Conclusion
mediating
Journal of Inflammation Research,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 6003 - 6021
Published: Dec. 1, 2023
The
maintenance
of
bone
homeostasis
is
dynamically
regulated
by
osteoblast-mediated
formation
and
osteoclast-mediated
resorption.
Abnormal
differentiation
osteoclast
insufficient
osteoblast
production
can
cause
diseases
such
as
osteoporosis.
As
one
the
highly
conserved
catabolic
pathways
in
eukaryotic
cells,
autophagy
plays
an
important
role
maintaining
cell
homeostasis,
stress
injury
repair,
proliferation
differentiation.
Numerous
studies
have
found
that
activity
essential
for
survival,
function
regulation
affect
metabolism
osteoblasts
osteoclasts,
thus
affecting
homeostasis.
Therefore,
using
a
theme,
this
review
outlines
basic
process
autophagy,
relationship
between
summarizes
latest
research
progress
common
autophagic
signaling
osteoclasts.
regulatory
effects
protein
molecules
natural
compounds
on
pathway
osteoclasts
discovered
current
are
summarized
discussed.
This
will
help
to
further
clarify
mechanism
osteoporosis,
understand
propose
new
therapeutic
strategies
ideas
anti-osteoporosis.
