Yiqi Yangxue formula inhibits cartilage degeneration in knee osteoarthritis by regulating LncRNA-UFC1/miR-34a/MMP-13 axis DOI Creative Commons
Ting Zhao,

X. Y. Wang,

Zhaofu Li

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118930 - 118930

Published: Oct. 10, 2024

Language: Английский

Integrated Network Pharmacology, Machine Learning and Experimental Validation to Identify the Key Targets and Compounds of TiaoShenGongJian for the Treatment of Breast Cancer DOI Open Access
Huiyan Ying, Weikaixin Kong, Xiangwei Xu

et al.

OncoTargets and Therapy, Journal Year: 2025, Volume and Issue: Volume 18, P. 49 - 71

Published: Jan. 1, 2025

TiaoShenGongJian (TSGJ) decoction, a traditional Chinese medicine for breast cancer, has unknown active compounds, targets, and mechanisms. This study identifies TSGJ's key targets compounds cancer treatment through network pharmacology, machine learning, experimental validation. Bioactive components of TSGJ were identified from the TCMSP database, cancer-related GeneCards, PharmGkb, RNA-seq datasets. Intersection these revealed therapeutic TSGJ. PPI analysis was performed via STRING, learning methods (SVM, RF, GLM, XGBoost) validated by GSE70905, GSE70947, GSE22820, TCGA-BRCA Pathway analyses molecular docking performed. core compounds' effectiveness confirmed MTT RT-qPCR assays. 160 common identified, with 30 hub analysis. Five predictive (HIF1A, CASP8, FOS, EGFR, PPARG) screened SVM. Their diagnostic, biomarker, immune, clinical values validated. Quercetin, luteolin, baicalein as components. Molecular their strong affinities predicted targets. These modulated induced cytotoxicity in cell lines similar way reveals main against supporting its potential prevention treatment.

Language: Английский

Citations

0
Unraveling the Mechanisms of Shaoyang Shenggu Decoction in Treating Knee Osteoarthritis through Mass Spectrometry and Bioinformatics DOI

Jingchi Li,

Wenhao Yang, Yunlong Xiao

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119835 - 119835

Published: April 1, 2025

Language: Английский

Citations

0
Deciphering the Role of LncRNAs in Osteoarthritis: Inflammatory Pathways Unveiled DOI Creative Commons

Kangyi Hu,

Haonan Wen,

Ting Song

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 6563 - 6581

Published: Sept. 1, 2024

Long non-coding RNA (LncRNA), with transcripts over 200 nucleotides in length, play critical roles numerous biological functions and have emerged as significant players the pathogenesis of osteoarthritis (OA), an inflammatory condition traditionally viewed a degenerative joint disease. This review comprehensively examines influence LncRNA on processes driving OA progression, focusing their role regulating gene expression, cellular activities, pathways. Notably, LncRNAs such MALAT1, H19, HOTAIR are upregulated exacerbate milieu by modulating key signaling pathways like NF-κB, TGF-β/SMAD, Wnt/β-catenin. Conversely, MEG3 GAS5, which downregulated OA, show potential dampening responses protecting against cartilage degradation influencing miRNA interactions cytokine production. By enhancing our understanding LncRNA' inflammation, we can better leverage them biomarkers for disease develop innovative therapeutic strategies management. paper aims to delineate mechanisms propose novel targets intervention.

Language: Английский

Citations

1
Yiqi Yangxue formula inhibits cartilage degeneration in knee osteoarthritis by regulating LncRNA-UFC1/miR-34a/MMP-13 axis DOI Creative Commons
Ting Zhao,

X. Y. Wang,

Zhaofu Li

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118930 - 118930

Published: Oct. 10, 2024

Language: Английский

Citations

0