Effects of Taekwondo training on thigh muscle cross-sectional area, health-related physical fitness, HbA1c, and GLP-1 in sedentary older women DOI Creative Commons
Jae‐Hyun Park, Bong‐Jo Kim, Minki Jeong

et al.

Frontiers in Sports and Active Living, Journal Year: 2025, Volume and Issue: 7

Published: April 3, 2025

Background Sedentary lifestyles in older individuals are associated with reduced physical function and an increased risk of metabolic diseases such as type 2 diabetes. Physical exercise can enhance muscle mass, insulin sensitivity, health. Taekwondo, a martial art that integrates both aerobic resistance components, may improve strength, balance, health individuals. This study investigated the effect long-term Taekwondo training on thigh cross-sectional area, related fitness, indicators sedentary women. Methods Seventeen participants (aged 65 years older, time 8 h more per day) were randomly assigned to group ( n = 9) control 8). Outcomes, including health-related Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), Glucagon-like peptide-1 (GLP-1) measured before after program. The underwent 60 min training, three times week 12 weeks. Variable changes over between groups analyzed using two-way repeated measures ANOVA performed significant interactions. Results exhibited reduction body weight, mass index, fat, mean arterial blood pressure p < 0.05), well lean lower limb 0.05). Improvements balance gait speed, stride observed indicating fall enhanced mobility. Laboratory analyses revealed triglyceride free fatty acids elevated HDL-cholesterol GLP-1 levels Increased area was inversely correlated fasting glucose, insulin, HOMA-IR, suggesting improved sensitivity glucose regulation. Conclusion Long-term fitness markers women, providing evidence its use effective intervention promote this population.

Language: Английский

Sarcopenic Obesity and Cardiometabolic Health and Mortality in Older Adults: a Growing Health Concern in an Ageing Population DOI Creative Commons
S. Goya Wannamethee, Janice L. Atkins

Current Diabetes Reports, Journal Year: 2023, Volume and Issue: 23(11), P. 307 - 314

Published: Aug. 11, 2023

Abstract Purpose of Review Sarcopenic obesity (SO) is a growing public health problem in older adults. Whether SO confers higher risk cardiometabolic disease and mortality than or sarcopenia alone still matter debate. We focus on recent findings Recent Findings associated with increased compared to non-sarcopenic obesity, but similar without obesity. cardiovascular (CVD), diabetes, physical disability alone. SO, the presence highest CVD chronic kidney disease. A definition diagnostic criteria for has recently been proposed (ESPEN EASO). Summary more adverse outcomes overall Future research required assess impact new outcomes.

Language: Английский

Citations

14
GLP-1 receptor agonists in the treatment of diabetic non–alcoholic steatohepatitis patients DOI Creative Commons
Ernest Adeghate

Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: 25(3), P. 223 - 232

Published: Feb. 11, 2024

Introduction Nonalcoholic fatty liver disease (NAFLD) is the most common hepatic affecting almost 30% of world population. Approximately 25% people with NAFLD develop nonalcoholic steatohepatitis (NASH), fulminant version disease. Diabetes mellitus present in 22.5% and 44.60% individuals NASH. This review was undertaken to examine current contribution glucagon-like peptide 1 (GLP-1) receptor agonists pharmacotherapy diabetic steatohepatitis.

Language: Английский

Citations

5
Sarcopenia: A dive into metabolism to promote a multimodal, preventive, and regenerative approach DOI Creative Commons
Virginia Boccardi

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 219, P. 111941 - 111941

Published: May 14, 2024

Sarcopenia, the age-related loss of skeletal muscle mass and function, poses a significant challenge in field gerontology, impacting health independence older adults. By synthesizing current research findings theoretical frameworks, this perspective elucidates multifaceted mechanisms underlying sarcopenia, mainly focusing on energy balance metabolic processes. Furthermore, manuscript explores implications sarcopenia overall outcomes, functional decline, quality life individuals.

Language: Английский

Citations

5
Nutrition of aging people with diabetes mellitus: Focus on sarcopenia DOI
Almog Shalit, Eleni Gerontiti,

Georgios Boutzios

et al.

Maturitas, Journal Year: 2024, Volume and Issue: 185, P. 107975 - 107975

Published: March 21, 2024

Language: Английский

Citations

4
New insight on the potential detrimental effect of metabolic syndrome on the Alzheimer disease neuropathology: Mechanistic role DOI Creative Commons

Naif H. Ali,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(23)

Published: Dec. 1, 2024

Abstract The metabolic syndrome or X is a clustering of different components counting insulin resistance (IR), glucose intolerance, visceral obesity, hypertension and dyslipidemia. It has been shown that IR dysregulation signalling play critical role in the development by initiating pathophysiology through induction glucolipotoxicity, impairment disposal triggering pro‐inflammatory response. Furthermore, unfavourably affects cognitive function neurodegenerative diseases such as Alzheimer disease (AD) inducing oxidative stress, neuroinflammation brain IR. These changes together with impair cerebrovascular reactivity leading to impairment. In addition, increases risk for AD. However, central mechanisms which amplify AD are not completely elucidated. Consequently, this narrative review aims revise from published articles association between regarding cellular subcellular pathways. conclusion, regarded potential factor neuropathology pathways initiation IR, activation inflammatory neuroinflammation.

Language: Английский

Citations

4
Medical Nutrition Therapy and Physical Exercise for Acute and Chronic Hyperglycemic Patients with Sarcopenia DOI Open Access
Ángel Luis Abad-González, Silvia Veses Martín, María Argente

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 499 - 499

Published: Jan. 29, 2025

A wide range of factors contribute to the overlap hyperglycemia—acute or chronic—and sarcopenia, as well their associated adverse consequences, which can lead impaired physical function, reduced quality life, and increased mortality risk. These include malnutrition (both overnutrition undernutrition) low levels activity. Hyperglycemia sarcopenia are interconnected through a vicious cycle events that mutually reinforce worsen each other. To explore this association, our review compiles evidence on: (i) impact hyperglycemia on motor muscle with focus mechanisms underlying biochemical changes in muscles individuals at risk diabetes sarcopenia; (ii) importance clinical assessment control under hyperglycemic conditions; (iii) potential benefits medical nutrition therapy activity muscle-targeted treatments for population. Based reviewed evidence, we conclude regular intake key functional nutrients, together structured supervised resistance and/or aerobic activity, help maintain euglycemia improve status all patients sarcopenia.

Language: Английский

Citations

0
Texture analysis of T1- and T2-weighted images identifies myofiber atrophy and grip strength decline in streptozotocin-induced type 1 diabetic sarcopenia rats DOI Creative Commons

Dong Xing,

Fang Liu,

Yufan Gao

et al.

Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 11, 2025

Type 1 diabetes mellitus is associated with accelerated skeletal muscle aging and sarcopenia, a condition characterized by mass function loss. Early noninvasive evaluation of microstructural damage critical for managing sarcopenia in diabetes. This study evaluated the potential MRI texture analysis as imaging tool to assess myofiber size grip strength alterations rat model diabetic sarcopenia. Twenty SD rats were randomly evenly allocated control (CON) (DS) groups. Blood glucose, body weight, forelimb measured weekly. In eighth week, axial T1WI T2WI scans performed extract 16 features gastrocnemius muscle. The fibers, including cross-sectional area, perimeter, minFeretDiam, was calculated from HE-stained images. Differences between two groups analyzed via t tests or Mann‒Whitney U tests. Receiver operating characteristic (ROC) conducted evaluate diagnostic performance features. Associations features, strength, assessed Spearman correlation analysis. DS group presented significant reductions (p < 0.001). Seven demonstrated high repeatability. Among them, T1WI_Entropy T2WI_Entropy significantly lower, whereas T1WI_Mean, T2WI_Mean, T2WI_Variance greater than 0.05 p ROC revealed that well differentiating CON (AUC 0.830 ~ 1.000). Strong correlations found parameters size. Muscle based on effectively differentiated type sarcopenic normal controls strong associations These findings indicate serve biomarkers diagnosing patients, suggesting are promising tools early detection monitoring atrophy

Language: Английский

Citations

0
Repeatability, reproducibility, and observer variability of body composition assessment with single-slice lumbar MRI DOI Creative Commons

Magdalena Nowak,

Luis Núñez,

CJ Hill

et al.

Discover Imaging., Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 13, 2025

Language: Английский

Citations

0
Personalised screening tool for early detection of sarcopenia in stroke patients: a machine learning-based comparative study DOI Creative Commons
Huan Yan, Juan Li, Yujie Li

et al.

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: Feb. 20, 2025

Sarcopenia is a common complication in patients with stroke, adversely affecting recovery and increasing mortality risk. However, no standardised tool exists for its screening this population. This study aims to identify factors influencing sarcopenia develop risk prediction model evaluate predictive performance. Data from 794 stroke were analysed assess demographic clinical characteristics. Variable selection was performed using least absolute shrinkage operator (LASSO) regression, followed by multivariate regression analysis. Logistic (LR), random forest (RF) XGBoost algorithms used construct models, the optimal subjected external validation. Internal validation conducted via bootstrap resampling, involved an additional cohort of 159 stroke. Model performance assessed area under curve (AUC), calibration curves decision analysis (DCA). Seven variables identified through LASSO The LR achieved highest AUC (0.805), outperforming RF (0.796) (0.780) models. Additionally, exhibited superior accuracy, precision, recall, specificity F1-score. External confirmed model's robustness, 0.816. Calibration DCA demonstrated their accuracy applicability. A model, presented as nomogram online calculator, developed Early may facilitate timely interventions improve patient outcomes.

Language: Английский

Citations

0
Bidirectional association between sarcopenia and depression: a systematic review and meta-analysis DOI
Xianzhong Meng,

Ze Wang,

Linyu Lyu

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 132, P. 105787 - 105787

Published: Feb. 21, 2025

Language: Английский

Citations

0