Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

International Journal of Nanomedicine, Journal Year: 2017, Volume and Issue: Volume 12, P. 7291 - 7309

Published: Oct. 1, 2017

Nanotechnology has recently gained increased attention for its capability to effectively diagnose and treat various tumors. Nanocarriers have been used circumvent the problems associated with conventional antitumor drug delivery systems, including their nonspecificity, severe side effects, burst release damaging normal cells. improve bioavailability therapeutic efficiency of drugs, while providing preferential accumulation at target site. A number nanocarriers developed; however, only a few them are clinically approved drugs intended actions targeted sites. The present review is divided into three main parts: first part presents introduction relevance in anticancer second encompasses targeting mechanisms surface functionalization on third covers description selected tumors, breast, lungs, colorectal pancreatic applications relative these This increases understanding tumor treatment promising use nanotechnology.

Language: Английский

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Adapting liposomes for oral drug delivery

Acta Pharmaceutica Sinica B, Journal Year: 2018, Volume and Issue: 9(1), P. 36 - 48

Published: June 20, 2018

Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility safety. Despite the success of parenteral liposomes, oral delivery liposomes is impeded by various barriers such instability in gastrointestinal tract, difficulties crossing biomembranes, mass production problems. By modulating compositions lipid bilayers adding polymers or ligands, both stability permeability can be greatly improved for delivery. This review provides an overview challenges current approaches toward liposomes.

Language: Английский

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Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies

Cancers, Journal Year: 2022, Volume and Issue: 14(7), P. 1732 - 1732

Published: March 29, 2022

Colorectal cancer (CRC) is the second most deadly cancer. Global incidence and mortality are likely to be increased in coming decades. Although deaths associated with CRC very high high-income countries, fatalities related growing developing countries too. detected early entirely curable by surgery subsequent medications. However, recurrence rate high, drug resistance increases treatment failure rate. Access diagnosis of for survival somewhat possible developed countries. these facilities rarely available Highlighting current status CRC, its development, risk factors, management crucial creating public awareness. Therefore, this review, we have comprehensively discussed global epidemiology, resistance, challenges, preventive strategies CRC. Additionally, there a brief discussion on development pathways recommendations preventing treating

Language: Английский

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Low-Dose Apatinib Optimizes Tumor Microenvironment and Potentiates Antitumor Effect of PD-1/PD-L1 Blockade in Lung Cancer

Cancer Immunology Research, Journal Year: 2019, Volume and Issue: 7(4), P. 630 - 643

Published: Feb. 12, 2019

Abstract The lack of response to treatment in most lung cancer patients suggests the value broadening benefit anti–PD-1/PD-L1 monotherapy. Judicious dosing antiangiogenic agents such as apatinib (VEGFR2-TKI) can modulate tumor immunosuppressive microenvironment, which contributes resistance treatment. We therefore hypothesized that inhibiting angiogenesis could enhance therapeutic efficacy PD-1/PD-L1 blockade. Here, using a syngeneic mouse model, we demonstrated low-dose alleviated hypoxia, increased infiltration CD8+ T cells, reduced recruitment tumor-associated macrophages and decreased TGFβ amounts both serum. Combining with anti–PD-L1 significantly retarded growth, number metastases, prolonged survival models. Anticancer activity was evident after coadministration anti–PD-1 small cohort pretreated advanced non–small cell cancer. Overall, our work shows rationale for combination blockade apatinib.

Language: Английский

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Liposomes and Extracellular Vesicles as Drug Delivery Systems: A Comparison of Composition, Pharmacokinetics, and Functionalization

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 11(5)

Published: June 24, 2021

Over the past decades, lipid-based nanoparticle drug delivery systems (DDS) have caught attention of researchers worldwide, encouraging field to rapidly develop improved ways for effective delivery. One most prominent examples is liposomes, which are spherical shaped artificial vesicles composed lipid bilayers and able encapsulate both hydrophilic hydrophobic materials. At same time, biological nanoparticles naturally secreted by cells, called extracellular (EVs), emerged as promising more complex biocompatible DDS. In this review paper, differences similarities in composition evaluated, critical mediators that affect their pharmacokinetics elucidate. Different strategies been assessed tweak liposomes EVs explored, detailing effects on circulation targeting capacity, cytoplasmic therapeutic cargo. Finally, whether a hybrid system, consisting combination only constituents vesicles, could offer best worlds discussed. Through these topics, novel leads further research provided and, importantly, gain insight what liposome EV can learn from each other.

Language: Английский

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Drug resistance in cancer: mechanisms and tackling strategies

Pharmacological Reports, Journal Year: 2020, Volume and Issue: 72(5), P. 1125 - 1151

Published: July 22, 2020

Language: Английский

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<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

International Journal of Nanomedicine, Journal Year: 2020, Volume and Issue: Volume 15, P. 2439 - 2483

Published: April 1, 2020

Abstract: Many types of research have distinctly addressed the efficacy natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these vitro vivo effects not been able to be translated clinical use because several factors such as inefficient systemic delivery bioavailability promising agents that significantly contribute this disconnection. Over past decades, extraordinary advances made successfully on development novel drug systems encapsulation active including organic, inorganic hybrid nanoparticles. The advanced formulas are confirmed benefits over conventional previously manner solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, physical chemical degradation. current review highlights nanocarrier compounds, their method preparation, type ingredients, biomedical applications. Keywords: nanomedicine, metabolite, application, carrier formulation,

Language: Английский

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Multifunctional graphene oxide nanoparticles for drug delivery in cancer

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 350, P. 26 - 59

Published: Aug. 13, 2022

Language: Английский

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Bioactive Loaded Novel Nano-Formulations for Targeted Drug Delivery and Their Therapeutic Potential

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(5), P. 1091 - 1091

Published: May 19, 2022

Plant-based medicines have received a lot of attention in recent years. Such been employed to treat medical conditions since ancient times, and those times only the observed symptoms were used determine dose accuracy, efficacy, therapy. Rather than novel formulations, current research work on plant-based has mostly concentrated medicinal active phytoconstituents. In past decades, however, researchers made significant progress developing “new drug delivery systems” (NDDS) enhance therapeutic efficacy reduce unwanted effects bioactive compounds. Nanocapsules, polymer micelles, liposomes, nanogels, phytosomes, nano-emulsions, transferosomes, microspheres, ethosomes, injectable hydrogels, polymeric nanoparticles, dendrimers, other innovative formulations all created using compounds plant extracts. The can improve solubility, bioavailability, stability, tissue distribution, protection from physical chemical damage, prolonged targeted administration, name few. study summarizes existing development new with focus herbal components.

Language: Английский

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A detailed insight of the tumor targeting using nanocarrier drug delivery system

Drug Delivery, Journal Year: 2023, Volume and Issue: 30(1)

Published: March 3, 2023

Human struggle against the deadly disease conditions is continued since ages. The contribution of science and technology in fighting these diseases cannot be ignored exclusively due to invention novel procedure products, extending their size ranges from micro nano. Recently nanotechnology has been gaining more consideration for its ability diagnose treat different cancers. Different nanoparticles have used evade issues related with conservative anticancer delivery systems, including nonspecificity, adverse effects burst release. These nanocarriers including, solid lipid (SLNs), liposomes, nano carriers (NLCs), micelles, nanocomposites, polymeric magnetic nanocarriers, brought revolutions antitumor drug delivery. Nanocarriers improved therapeutic efficacy drugs better accumulation at specific site sustained release, bioavailability apoptosis cancer cells while bypassing normal cells. In this review, targeting techniques surface modification on are discussed briefly possible challenges opportunities. It can concluded that understanding role nanomedicine tumor treatment significant, therefore, modern progressions arena essential considered a prosperous today an affluent future patients.

Language: Английский

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