Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine

Journal of Nanomaterials, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 26

Published: Feb. 27, 2019

The study of nanostructured drug delivery systems allows the development novel platforms for efficient transport and controlled release molecules in harsh microenvironment diseased tissues living systems, thus offering a wide range functional nanoplatforms smart application biotechnology nanomedicine. This article highlights recent advances nanocarriers composed organic (including polymeric micelles vesicles, liposomes, dendrimers, hydrogels) inorganic quantum dots, gold mesoporous silica nanoparticles) materials. Despite remarkable developments synthetic methodologies, most all nanocarriers’ action is associated with number unwanted side effects that diminish their use nanomedicine applications. some critical issues design engineering nanocarrier applications, arising from complex environment multiform interactions established within specific biological media.

Language: Английский

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Therapeutic Nanoparticles and Their Targeted Delivery Applications

Molecules, Journal Year: 2020, Volume and Issue: 25(9), P. 2193 - 2193

Published: May 8, 2020

Nanotechnology offers many advantages in various fields of science. In this regard, nanoparticles are the essential building blocks nanotechnology. Recent advances nanotechnology have proven that acquire a great potential medical applications. Formation stable interactions with ligands, variability size and shape, high carrier capacity, convenience binding both hydrophilic hydrophobic substances make favorable platforms for target-specific controlled delivery micro- macromolecules disease therapy. Nanoparticles combined therapeutic agents overcome problems associated conventional therapy; however, some issues like side effects toxicity still debated should be well concerned before their utilization biological systems. It is therefore important to understand specific properties strategies. Here, we provide an overview on unique features We emphasize type clinically used specificity applications, as current strategies diseases such cancer, infectious, autoimmune, cardiovascular, neurodegenerative, ocular, pulmonary diseases. Understanding characteristics environment will enable us establish novel treatment, prevention, diagnosis diseases, particularly untreatable ones.

Language: Английский

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Porous scaffolds for bone regeneration

Journal of Science Advanced Materials and Devices, Journal Year: 2020, Volume and Issue: 5(1), P. 1 - 9

Published: Feb. 7, 2020

Globally, bone fractures due to osteoporosis occur every 20 s in people aged over 50 years. The significant healthcare costs required manage this problem are further exacerbated by the long healing times experienced with current treatment practices. Novel approaches such as tissue engineering, is using biomaterial scaffolds stimulate and guide regeneration of damaged that cannot heal spontaneously. Scaffolds provide a three-dimensional network mimics extra cellular micro-environment supporting viability, attachment, growth migration cells whilst maintaining structure regenerated vivo. osteogenic capability scaffold influenced interconnections between pores which facilitate cell distribution, integration host capillary ingrowth. Hence, preparation applicable pore size interconnectivity issue engineering. To be effective however vivo, must also cope requirements for physiological mechanical loading. This review focuses on relationship porosity subsequent osteogenesis, vascularisation degradation during regeneration.

Language: Английский

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Breast cancer: Biology, biomarkers, and treatments

International Immunopharmacology, Journal Year: 2020, Volume and Issue: 84, P. 106535 - 106535

Published: April 29, 2020

Language: Английский

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Recent advances in polymeric drug delivery systems

Biomaterials Research, Journal Year: 2020, Volume and Issue: 24(1)

Published: June 6, 2020

Abstract Background Polymeric drug delivery systems have been achieved great development in the last two decades. has defined as a formulation or device that enables introduction of therapeutic substance into body. Biodegradable and bio-reducible polymers make magic possible choice for lot new systems. The future prospects research practical applications required field. Main body Natural such arginine, chitosan, dextrin, polysaccharides, poly (glycolic acid), (lactic hyaluronic acid treated polymeric Synthetic (2-hydroxyethyl methacrylate), poly(N-isopropyl acrylamide)s, poly(ethylenimine)s, dendritic polymers, biodegradable bio-absorbable also discussed delivery. Targeting delivery, biomimetic bio-related systems, drug-free macromolecular therapeutics In gene virial vectors non-virial briefly analyzed. are polyethylenimine derivatives, copolymers, conjugated DNA conjugates RNA Conclusion based on natural synthetic rapidly emerging to pharmaceutical fields. fruitful progresses made application biocompatible copolymers dendrimers cancer treatment, including their use potent anticancer drugs. Combining perspectives from biological fields will provide paradigm design

Language: Английский

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Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

Biomaterials, Journal Year: 2019, Volume and Issue: 224, P. 119491 - 119491

Published: Sept. 14, 2019

Language: Английский

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Nanomedicine review: clinical developments in liposomal applications

Cancer Nanotechnology, Journal Year: 2019, Volume and Issue: 10(1)

Published: Dec. 1, 2019

Abstract Background In recent years, disease treatment has evolved strategies that require increase in pharmaceutical agent’s efficacy and selectivity while decreasing their toxicity normal tissues. These requirements have led to the development of nanoscale liposome systems for drug release. This review focuses on lipid features, pharmacological properties liposomal formulations clinical studies application. Main body Several lipids are available, but could affect or efficiency formulations. Many been developed currently market. Proper selection is essential effect be improved. Most use mainly zwitterionic, cationic anionic lipids, PEG and/or cholesterol, which different effects stability, pharmacokinetics delivery formulation. Clinical trials shown liposomes pharmacologically pharmacokinetically more efficient than drug-alone treating acute myeloid leukemia, hepatitis A, pain management, ovary, gastric breast lung cancer, among others. Conclusion Liposomal less toxic drugs alone better parameters. Although they seem first choice various diseases, further research about dosage regimen regarding dose time needs carried out.

Language: Английский

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Magnetic Nanoparticles in Cancer Therapy and Diagnosis

Advanced Healthcare Materials, Journal Year: 2020, Volume and Issue: 9(9)

Published: March 20, 2020

There is urgency for the development of nanomaterials that can meet emerging biomedical needs. Magnetic nanoparticles (MNPs) offer high magnetic moments and surface-area-to-volume ratios make them attractive hyperthermia therapy cancer targeted drug delivery. Additionally, they function as contrast agents resonance imaging (MRI) improve sensitivity biosensors diagnostic tools. Recent advancements in nanotechnology have resulted realization next generation MNPs suitable these other applications. This review discusses methods utilized fabrication engineering MNPs. progress use therapy, controlling release, MRI, biosensing also critically reviewed. Finally, challenges field potential opportunities toward improving their properties are discussed.

Language: Английский

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Emerging trends in the novel drug delivery approaches for the treatment of lung cancer

Chemico-Biological Interactions, Journal Year: 2019, Volume and Issue: 309, P. 108720 - 108720

Published: June 18, 2019

Language: Английский

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Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy

Seminars in Cancer Biology, Journal Year: 2019, Volume and Issue: 69, P. 166 - 177

Published: Nov. 9, 2019

Language: Английский

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