Drug release study of the chitosan-based nanoparticles

Heliyon, Journal Year: 2021, Volume and Issue: 8(1), P. e08674 - e08674

Published: Dec. 24, 2021

Recently, multifunctional drug delivery systems (DDSs) have been designed to provide a comprehensive approach with multiple functionalities, including diagnostic imaging, targeted delivery, and controlled release. Chitosan-based nanoparticles (CSNPs) are employed as imaging delivering the particular sites in regulated manner. Drug release is an important factor ensuring high reproducibility, stability, quality control of CSNPs, scientific-based for developing CSNPs. Several factors influence from composition, composition ratio, ingredient interactions, preparation methods. Early, CSNPs were used improving solubility, pharmacokinetics, pharmacotherapeutics properties. Chitosan has developed toward system by exploring positively charged properties modifiable functional groups. Various modifications polymer backbone, charge, or groups will undoubtedly affect The significant on its therapeutic actions. Our review's objective was summarize discuss relationship between modification kinetics model. Kinetic models help describe rate, leading increased efficiency, accuracy, safety dose, optimizing device's design, evaluating improvement patient compatibility. In conclusion, almost all showed bi-phasic release, initial burst time followed manner achieving expected stimuli external can be applied. promising technique systems.

Language: Английский

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Applications of nanotechnology in drug delivery to the central nervous system

Biomedicine & Pharmacotherapy, Journal Year: 2019, Volume and Issue: 111, P. 666 - 675

Published: Jan. 3, 2019

In recent years, the researchers and drug designers have given growing attention to new nanotechnology strategies improve delivery central nervous system (CNS). Nanotechnology has a great potential affect treatment of neurological disorders, mainly Alzheimer's disease, Parkinson's brain tumors, stroke. With regard neurodegeneration, several studies showed that nanomaterials been successfully used for treatments CNS disorders. this regard, nanocarriers facilitated targeted chemotherapeutics resulting in efficient inhibition disease progression malignant tumors. Therefore, most efficacious application is use these substances enhances overall effect highlights importance nano-therapeutics. This study was conducted review evidence on applications designing systems with ability cross through blood-brain barrier (BBB) order transfer therapeutic agents CNS.

Language: Английский

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Application of Solid Lipid Nanoparticles to Improve the Efficiency of Anticancer Drugs

Nanomaterials, Journal Year: 2019, Volume and Issue: 9(3), P. 474 - 474

Published: March 22, 2019

Drug delivery systems have opened new avenues to improve the therapeutic effects of already-efficient molecules. Particularly, Solid Lipid Nanoparticles (SLNs) emerged as promising nanocarriers in cancer therapy. SLNs offer remarkable advantages such low toxicity, high bioavailability drugs, versatility incorporation hydrophilic and lipophilic feasibility large-scale production. Their molecular structure is crucial obtain quality SLN preparations it determined by relationship between composition preparation method. Additionally, allow overcoming several physiological barriers that hinder drug tumors are also able escape multidrug resistance mechanisms, characteristic cells. Focusing on cell delivery, can target cells different passive mechanisms take advantage tumor microenvironment, active surface modification SLNs, codelivery mechanisms. incorporate many drugs proven be effective types (i.e., breast, lung, colon, liver, brain), corroborating their potential. Finally, has taken into account there still some challenges face application anticancer treatments but possibilities seem high.

Language: Английский

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Recent updates on drug resistance in Mycobacterium tuberculosis

Journal of Applied Microbiology, Journal Year: 2019, Volume and Issue: 128(6), P. 1547 - 1567

Published: Oct. 9, 2019

Tuberculosis (TB) along with acquired immune deficiency syndrome and malaria rank among the top three fatal infectious diseases which pose threat to global public health, especially in middle low income countries. TB caused by Mycobacterium tuberculosis (Mtb) is an airborne disease one‐third of world's population gets infected leading nearly 1·6 million deaths annually. drugs are administered different combinations four first‐line (rifampicin, isoniazid, pyrazinamide ethambutol) form core treatment regimens initial phase 6–9 months. Several reasons account for failure therapy such as (i) late diagnosis, (ii) lack timely proper administration effective drugs, (iii) lower availability less toxic, inexpensive (iv) long duration, (v) nonadherence drug regimen (vi) evolution drug‐resistant strains. Drug‐resistant poses a significant challenge control programs. In background worldwide emergence 558 000 new cases resistance rifampicin year 2017 them, 82% becoming multidrug‐resistant (MDR‐TB), it essential continuously update knowledge on mechanisms molecular basis Mtb resistance. This narrative traditional review summarizes progress anti‐tubercular agents, their mode action Mtb. The aim this provide recent updates mechanisms, newly developed/repurposed anti‐TB agents pipeline international recommendations manage MDR‐TB. It based literature WHO guidelines aims facilitate better understanding clinical management.

Language: Английский

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Review on Natural, Incidental, Bioinspired, and Engineered Nanomaterials: History, Definitions, Classifications, Synthesis, Properties, Market, Toxicities, Risks, and Regulations

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(2), P. 177 - 177

Published: Jan. 6, 2022

Nanomaterials are becoming important materials in several fields and industries thanks to their very reduced size shape-related features. Scientists think that nanoparticles nanostructured originated during the Big Bang process from meteorites leading formation of universe Earth. Since 1990, term nanotechnology became popular due advances imaging technologies paved way specific industrial applications. Currently, synthesized on a large scale indispensable for many industries. This fact fosters supports research biochemistry, biophysics, biochemical engineering Recently, has been combined with other sciences fabricate new forms nanomaterials could be used, instance, diagnostic tools, drug delivery systems, energy generation/storage, environmental remediation as well agriculture food processing. In contrast traditional materials, features can integrated into nanoparticles, nanostructures, nanosystems by simply modifying scale, shape, composition. article first summarizes history nanotechnology. Followed progress led improved synthesis processes produce different nanostructures characterized The content finally presents various origins sources nanomaterials, strategies, toxicity, risks, regulations, self-aggregation.

Language: Английский

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Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives

International Journal of Nanomedicine, Journal Year: 2021, Volume and Issue: Volume 16, P. 1313 - 1330

Published: Feb. 1, 2021

Nanotechnology has been actively integrated as drug carriers over the last few years to treat various cancers. The main hurdle in clinical management of cancer is development multidrug resistance against chemotherapeutic agents. To overcome limitations chemotherapy, researchers have developing technological advances for significant progress oncotherapy by enabling delivery agents at increased content levels targeted spots. Several nano-drug systems designed tumor-targeting are evaluated preclinical and trials showed promising outcomes cancerous tumors' management. This review describes nanocarrier's importance managing different types cancers emphasizing nanocarriers nanotherapeutics. It also highlights recent nanocarriers-based systems, including polymeric nanocarriers, micelles, nanotubes, dendrimers, magnetic nanoparticles, solid lipid quantum dots (QDs). nanocarrier-based composites discussed terms their structure, characteristics, therapeutic applications oncology. conclude, challenges future exploration opportunities chemotherapeutics presented.

Language: Английский

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Functionalizing nanoparticles with cancer-targeting antibodies: A comparison of strategies

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 320, P. 180 - 200

Published: Jan. 21, 2020

Language: Английский

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Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

Cancer Cell International, Journal Year: 2021, Volume and Issue: 21(1)

Published: June 24, 2021

Abstract The study describes the current state of knowledge on nanotechnology and its utilization in medicine. focus this manuscript was properties, usage safety, potentially valuable applications chitosan-based nanomaterials. Chitosan nanoparticles have high importance nanomedicine, biomedical engineering, discovery development new drugs. reviewed studies regarding use for creating release systems with improved bioavailability, increased specificity sensitivity, reduced pharmacological toxicity Nowadays, effective cancer treatment is a global problem, recent advances nanomedicine are great importance. Special attention put application chitosan developing system anticancer drug delivery. Pre-clinical clinical support nanomedicine. This overviews last progresses utilization, stability, bioavailability nanoencapsulation their safety.

Language: Английский

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Methods for Reducing the Toxicity of Metal and Metal Oxide NPs as Biomedicine

Materials, Journal Year: 2020, Volume and Issue: 13(2), P. 279 - 279

Published: Jan. 8, 2020

The rapid development of medicine has forced equally progress in the field pharmaceuticals. In connection with expensive and time-consuming process finding new drugs, great emphasis is put on design use metal oxides nanoparticles nanomedicine. main focus comprehensive presentation both physicochemical properties possibilities using, particular, silver (Ag) gold (Au) nanoparticles, as well zinc oxide (ZnO) titanium (TiO

Language: Английский

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A review on anti-inflammatory activity of green synthesized zinc oxide nanoparticle: Mechanism-based approach

Bioorganic Chemistry, Journal Year: 2019, Volume and Issue: 94, P. 103423 - 103423

Published: Nov. 6, 2019

Language: Английский

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