Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
169, P. 115812 - 115812
Published: Nov. 16, 2023
Gut
microbiota
(GM)
contributes
to
the
production
of
immune-regulatory
molecules
and
cytokines.
However,
our
understanding
regarding
intricate
relationship
between
Lactobacillus
plantarum
GM
on
regulation
immune
function
remained
limited.
To
investigate
effect
an
immunosuppressed
mouse
model,
we
employed
cyclophosphamide
treatment
conducted
various
analysis
including
H&E
(hematoxylin-eosin
staining),
immunohistochemistry,
16S
rRNA
gene
sequencing,
RT-PCR.
Our
results
demonstrated
that
administration
had
significant
immunoenhancing
effects
in
immune-suppressed
mice,
as
evidenced
by
restoration
functional
expression
specific
markers
spleen
increase
number
goblet
cells
intestine
(P
<
0.05).
Microbial
taxonomic
revealed
alterations
gut
composition,
characterized
a
decrease
richness
Firmicutes
proportion
Verrucomicrobia
Actinobacteria
following
treatment.
Furthermore,
significantly
suppressed
mRNA
inflammatory
cytokines
0.05),
which
were
subsequently
restored
after
plantarum.
These
observations
provide
valuable
insights
into
complex
interplay
probiotics,
microbiota,
system
functioning.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(2), P. 594 - 594
Published: Jan. 6, 2022
Intestinal
homeostasis
is
a
dynamic
balance
involving
the
interaction
between
host
intestinal
mucosa,
immune
barrier,
microecology,
nutrients,
and
metabolites.
Once
out
of
balance,
it
will
increase
risk
diseases
also
closely
associated
with
some
systemic
diseases.
Probiotics
(Escherichia
coli
Nissle
1917,
Akkermansia
muciniphila,
Clostridium
butyricum,
lactic
acid
bacteria
Bifidobacterium
spp.),
maintaining
gut
through
direct
intestine,
can
exist
as
specific
agent
to
prevent,
alleviate,
or
cure
intestinal-related
With
genetic
engineering
technology
advancing,
probiotics
show
targeted
therapeutic
properties.
The
aims
this
review
are
summarize
roles
potential
native
engineered
in
oncology,
inflammatory
bowel
disease,
obesity,
discussing
applications
these
probiotics.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(7), P. 2101 - 2101
Published: March 31, 2023
Cancer
immunotherapy
is
a
treatment
modality
that
aims
to
stimulate
the
anti-tumor
immunity
of
host
elicit
favorable
clinical
outcomes.
Immune
checkpoint
inhibitors
(ICIs)
gained
traction
due
lasting
effects
and
better
tolerance
in
patients
carrying
solid
tumors
comparison
conventional
treatment.
However,
significant
portion
may
present
primary
or
acquired
resistance
(non-responders),
thus,
they
have
limited
therapeutic
Resistance
ICIs
can
be
derived
from
host-related,
tumor-intrinsic,
environmental
factors.
Recent
studies
suggest
correlation
gut
microbiota
with
response
as
well
incidence
adverse
events.
Currently,
preclinical
aim
elucidate
unique
microbial
signatures
related
ICI
immunity,
employing
metagenomics
and/or
multi-omics.
Decoding
this
complex
relationship
provide
basis
for
manipulating
malleable
structure
enhance
success.
Here,
we
delve
into
factors
affecting
ICIs,
focusing
on
intricate
microbiome–immunity
interplay.
Additionally,
review
discuss
future
trends
directions
promising
field.
Pharmacological Research,
Journal Year:
2023,
Volume and Issue:
196, P. 106916 - 106916
Published: Sept. 9, 2023
In
the
wake
of
development
metagenomic,
metabolomic,
and
metatranscriptomic
approaches,
intricate
interactions
between
host
various
microbes
are
now
being
progressively
understood.
Numerous
studies
have
demonstrated
evident
changes
in
gut
microbiota
during
process
a
variety
diseases,
such
as
diabetes,
obesity,
aging,
cancers.
Notably,
is
viewed
potential
source
novel
therapeutics.
Currently,
Next-generation
probiotics
(NGPs)
gaining
popularity
therapeutic
agents
that
alter
affect
cancer
development.
Akkermansia
muciniphila
(A.
muciniphila),
representative
commensal
bacterium,
has
received
substantial
attention
over
past
decade
promising
NGP.
The
components
metabolites
A.
can
directly
or
indirectly
tumorigenesis,
particular
through
its
effects
on
antitumor
immunosurveillance,
including
stimulation
pattern
recognition
receptors
(PRRs),
which
also
leads
to
better
outcomes
situations,
prevention
curation
this
article,
we
systematically
summarize
role
tumorigenesis
(involving
gastrointestinal
non-gastrointestinal
cancers)
tumor
therapy.
particular,
carefully
discuss
some
critical
scientific
issues
need
be
solved
for
future
using
beneficial
bacterium
treatment,
might
provide
bright
clues
assistance
application
drugs
targeting
clinical
oncotherapy.
The World Journal of Men s Health,
Journal Year:
2023,
Volume and Issue:
41(4), P. 759 - 759
Published: Jan. 1, 2023
The
human
gut
microbiota
changes
under
the
influence
of
environmental
and
genetic
factors,
affecting
health.
Extensive
studies
have
revealed
that
microbiome
is
closely
associated
with
many
non-intestinal
diseases.
Among
these,
on
cancer
biology
efficacy
therapy
has
attracted
much
attention.
Prostate
cells
are
affected
by
direct
contact
local
tissues
urine,
a
relationship
between
prostate
been
suggested.
In
microbiota,
bacterial
composition
differs
depending
characteristics,
such
as
histological
grade
castration
resistance.
Moreover,
involvement
several
intestinal
bacteria
in
testosterone
metabolism
demonstrated,
suggesting
they
may
affect
progression
treatment
through
this
mechanism.
Basic
research
indicates
also
plays
an
important
role
underlying
multiple
mechanisms
owing
to
activity
microbial-derived
metabolites
components.
review,
we
describe
evidence
surrounding
emerging
cancer,
termed
"gut-prostate
axis."
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
169, P. 115812 - 115812
Published: Nov. 16, 2023
Gut
microbiota
(GM)
contributes
to
the
production
of
immune-regulatory
molecules
and
cytokines.
However,
our
understanding
regarding
intricate
relationship
between
Lactobacillus
plantarum
GM
on
regulation
immune
function
remained
limited.
To
investigate
effect
an
immunosuppressed
mouse
model,
we
employed
cyclophosphamide
treatment
conducted
various
analysis
including
H&E
(hematoxylin-eosin
staining),
immunohistochemistry,
16S
rRNA
gene
sequencing,
RT-PCR.
Our
results
demonstrated
that
administration
had
significant
immunoenhancing
effects
in
immune-suppressed
mice,
as
evidenced
by
restoration
functional
expression
specific
markers
spleen
increase
number
goblet
cells
intestine
(P
<
0.05).
Microbial
taxonomic
revealed
alterations
gut
composition,
characterized
a
decrease
richness
Firmicutes
proportion
Verrucomicrobia
Actinobacteria
following
treatment.
Furthermore,
significantly
suppressed
mRNA
inflammatory
cytokines
0.05),
which
were
subsequently
restored
after
plantarum.
These
observations
provide
valuable
insights
into
complex
interplay
probiotics,
microbiota,
system
functioning.
