Synthesis and characterization of cerium oxide-bacteriocin nanohybride with synergistic biological activities DOI Open Access

Sana M.H. Al-Shimmary,

Zina Hashem Shehab, Emad Hamdi Jassim

et al.

Egyptian Journal of Basic and Applied Sciences, Journal Year: 2024, Volume and Issue: 12(1), P. 1 - 16

Published: Dec. 17, 2024

The creation of adjuvants that can increase the effectiveness therapeutically accessible antibiotics is overall strategy due to limited therapeutic choices available for treating multidrug-resistant (MDR) infections. Thus, goal this work was create a novel cerium oxide-bacteriocin nanohybrid (CeO2-bacteriocin nanohybrid), which purified from Lactobacillus acidophilus (L. acidophilus) and may help bacteriocins become more bioactive overcome several obstacles. Characterization nanohybrids via methods has been performed. X-ray diffraction (XRD) revealed an average crystallite size 37.19 nm. Transmission electron microscopy (TEM) confirmed CeO2-bacteriocin composed regular spheres oval shapes with sizes ranging 6 61 Scanning (SEM) demonstrated structure tended be spherical, varying between 45 65 As result, showed strong antibacterial activity than bacteriocin alone, there were highly significant (p ≤ 0.01)differences in effects alone on growth each tested bacteria Minimum Inhibition Concentration Bactericidal against MDR Staphylococcus aureus XDR Acinetobacter baumannii recorded. promising antibiofilm all bacteria. new considered choice as antioxidant compound DPPH (2,2-diphenyl-1-picrylhydrazyl) vitro cytotoxicity breast cancer cells (MDA-MB-231 cells).

Language: Английский

Green synthesis of metal oxide nanoparticles, and their various applications DOI Creative Commons
Uyiosa Osagie Aigbe, Otolorin Adelaja Osibote

Journal of Hazardous Materials Advances, Journal Year: 2024, Volume and Issue: 13, P. 100401 - 100401

Published: Jan. 13, 2024

Bio-synthesized metal oxide (MeO) nanoparticles (NPs) have triggered a huge global research interest owing to their advancement and various environmental remediation, personal care products, medical, energy, sensing, water treatment applications. They demonstrate developing assets in industries, remarkably with heightened physicochemical, optical, mechanical, electronic attributes. The physical chemical routes been sticking point the production of MeO NPs, natural risks linked utilizing these approaches. growth NPs via biologic method employing plants microorganisms as precursor material for metal-ions (MIs) reduction stabilization has focus scientists recent years. Hence, this review, comprehensive brief bio-synthesis approaches using plant extracts (PEs) microorganism components well factors affecting bio-production applications toxicity were considered.

Language: Английский

Citations

48
The regulatory mechanisms of cerium oxide nanoparticles in oxidative stress and emerging applications in refractory wound care DOI Creative Commons
Lijun Yi,

Lijian Yu,

Shouying Chen

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 2, 2024

Cerium oxide nanoparticles (CeNPs) have emerged as a potent therapeutic agent in the realm of wound healing, attributing their efficacy predominantly to exceptional antioxidant properties. Mimicking activity endogenous enzymes, CeNPs alleviate oxidative stress and curtail generation inflammatory mediators, thus expediting healing process. Their application spans various disease models, showcasing potential treating responses infections, particularly stress-induced chronic wounds such diabetic ulcers, radiation-induced skin injuries, psoriasis. Despite promising advancements laboratory studies, clinical translation is challenged by several factors, including biocompatibility, toxicity, effective drug delivery, development multifunctional compounds. Addressing these challenges necessitates CeNP synthesis functionalization, novel nano delivery systems, comprehensive bio effectiveness safety evaluations. This paper reviews progress highlighting mechanisms, applications, challenges, future perspectives therapeutics.

Language: Английский

Citations

9
二氧化铈纳米颗粒: 生物医学应用和毒性 DOI

Xiaoxuan Fu,

Peng Li, Xi Chen

et al.

Journal of Zhejiang University SCIENCE B, Journal Year: 2024, Volume and Issue: 25(5), P. 361 - 388

Published: May 1, 2024

Language: Английский

Citations

8
Recent progress and drug delivery applications of surface-functionalized inorganic nanoparticles in cancer therapy DOI
Alam Zeb,

Maleeha Gul,

Thi‐Thao‐Linh Nguyen

et al.

Journal of Pharmaceutical Investigation, Journal Year: 2023, Volume and Issue: 53(6), P. 743 - 779

Published: Sept. 16, 2023

Language: Английский

Citations

12
The Role of Inorganic Nanomaterials in Overcoming Challenges in Colorectal Cancer Diagnosis and Therapy DOI Creative Commons
Jun Wang, Hui Wang, Falong Zou

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 409 - 409

Published: March 25, 2025

Colorectal cancer poses a significant threat to human health due its high aggressiveness and poor prognosis. Key factors impacting patient outcomes include post-surgical recurrence, chemotherapeutic drug resistance, insensitivity immunotherapy. Consequently, early diagnosis the development of effective targeted therapies are essential for improving prevention treatment strategies. Inorganic nanomaterials have gained prominence in colorectal owing their unique size, advantageous properties, modifiability. Various types inorganic nanomaterials—such as metal-based, metal oxide, quantum dots, magnetic nanoparticles, carbon-based, rare-earth nanomaterials—have demonstrated potential enhancing multimodal imaging, delivery, synergistic therapies. These advancements underscore critical role therapeutic outcomes. This review highlights properties nanomaterials, summarizes recent applications progress treatment, discusses challenges translating these materials into clinical use. It aims provide valuable insights future research application management.

Language: Английский

Citations

0
Eco-friendly synthesis of Ag/CeO2 and CuO/CeO2 nanocomposites using Curcuma longa extract and assessment of their antioxidant, antifungal, and cytotoxic activities DOI Creative Commons
Khaled M. Elattar,

Abeer A. Ghoniem,

Fatimah Al-Otibi

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(16), P. 12100 - 12116

Published: Jan. 1, 2025

Ag/CeO 2 and CuO/CeO nanocomposites were synthesized using Curcuma longa extract showed notable antioxidant, antifungal activity against M. phaseolina , cytotoxicity toward MCF-7 cells.

Language: Английский

Citations

0
Fabrication of polydopamine-altered PCL/PLGA nanofibrous scaffolds on cerium to enhance cytocompatibility, microbial inhibition, and improved osteogenic properties for tissue regeneration in orofacial treatment DOI
Chong Luo,

Cheng Kang,

Shi Qiu

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 766, P. 151852 - 151852

Published: April 18, 2025

Language: Английский

Citations

0
Cerium oxide nanoparticles for surgery, plastic surgery and aesthetic medicine DOI
Н.Е. Мантурова, Stupin Va, Ekaterina Silina

et al.

Plastic Surgery and Aesthetic Medicine, Journal Year: 2023, Volume and Issue: 3, P. 120 - 120

Published: Jan. 1, 2023

Language: Английский

Citations

5
Synthesis and characterization of cerium oxide-bacteriocin nanohybride with synergistic biological activities DOI Open Access

Sana M.H. Al-Shimmary,

Zina Hashem Shehab, Emad Hamdi Jassim

et al.

Egyptian Journal of Basic and Applied Sciences, Journal Year: 2024, Volume and Issue: 12(1), P. 1 - 16

Published: Dec. 17, 2024

The creation of adjuvants that can increase the effectiveness therapeutically accessible antibiotics is overall strategy due to limited therapeutic choices available for treating multidrug-resistant (MDR) infections. Thus, goal this work was create a novel cerium oxide-bacteriocin nanohybrid (CeO2-bacteriocin nanohybrid), which purified from Lactobacillus acidophilus (L. acidophilus) and may help bacteriocins become more bioactive overcome several obstacles. Characterization nanohybrids via methods has been performed. X-ray diffraction (XRD) revealed an average crystallite size 37.19 nm. Transmission electron microscopy (TEM) confirmed CeO2-bacteriocin composed regular spheres oval shapes with sizes ranging 6 61 Scanning (SEM) demonstrated structure tended be spherical, varying between 45 65 As result, showed strong antibacterial activity than bacteriocin alone, there were highly significant (p ≤ 0.01)differences in effects alone on growth each tested bacteria Minimum Inhibition Concentration Bactericidal against MDR Staphylococcus aureus XDR Acinetobacter baumannii recorded. promising antibiofilm all bacteria. new considered choice as antioxidant compound DPPH (2,2-diphenyl-1-picrylhydrazyl) vitro cytotoxicity breast cancer cells (MDA-MB-231 cells).

Language: Английский

Citations

0