Ferroptosis as a promising therapeutic strategy for melanoma DOI Creative Commons
Na Ta, Xiaodong Jiang, Yongchun Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 19, 2023

Malignant melanoma (MM) is the most common and deadliest type of skin cancer associated with high mortality rates across all races ethnicities. Although present treatment options combined surgery provide short-term clinical benefit in patients early diagnosis non-metastatic MM significantly increases probability survival, no efficacious treatments are available for MM. The etiology pathogenesis complex. Acquired drug resistance a pool prognosis advanced-stage Thus, these require new therapeutic strategies to improve their response prognosis. Multiple studies have revealed that ferroptosis, non-apoptotic form regulated cell death (RCD) characterized by iron dependant lipid peroxidation, can prevent development Recent indicated targeting ferroptosis promising strategy This review article summarizes core mechanisms underlying cells its potential role as target We emphasize emerging types small molecules inducing pathways boosting antitumor activity BRAFi immunotherapy uncover beneficial effects treat also summarize application nanosensitizer-mediated unique dynamic ferroptosis-based nanodrug suggests pharmacological induction may be

Language: Английский

Injectable hydrogels for personalized cancer immunotherapies DOI Open Access
Neda Mohaghegh, Amir Ahari, Fatemeh Zehtabi

et al.

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 172, P. 67 - 91

Published: Oct. 6, 2023

Language: Английский

Citations

32
Recent Advances in Hydrogel-Based Phototherapy for Tumor Treatment DOI Creative Commons
Shuaiqi Gan, Yongzhi Wu, Xu Zhang

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(4), P. 286 - 286

Published: April 1, 2023

Phototherapeutic agent-based phototherapies activated by light have proven to be safe modalities for the treatment of various malignant tumor indications. The two main include photothermal therapy, which causes localized thermal damage target lesions, and photodynamic chemical generated reactive oxygen species (ROS). Conventional suffer a major shortcoming in their clinical application due phototoxicity, primarily arises from uncontrolled distribution phototherapeutic agents vivo. For successful antitumor phototherapy, it is essential ensure generation heat or ROS specifically occurs at site. To minimize reverse side effects phototherapy while improving its therapeutic performance, extensive research has focused on developing hydrogel-based treatment. utilization hydrogels as drug carriers allows sustained delivery sites, thereby limiting adverse effects. Herein, we summarize recent advancements design offer comprehensive overview latest advances combination with other treatment, discuss current status phototherapy.

Language: Английский

Citations

26
Biological Applications of Thermoplasmonics DOI Creative Commons
Victoria Thusgaard Ruhoff, Mohammad Reza Arastoo, Guillermo Moreno-Pescador

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(3), P. 777 - 789

Published: Jan. 6, 2024

Thermoplasmonics has emerged as an extraordinarily versatile tool with profound applications across various biological domains ranging from medical science to cell biology and biophysics. The key feature of nanoscale plasmonic heating involves remote activation by applying laser irradiation nanostructures that are designed optimally convert light into heat. This unique capability paves the way for a diverse array applications, facilitating exploration critical processes such differentiation, repair, signaling, protein functionality, advancement biosensing techniques. Of particular significance is rapid heat cycling can be achieved through thermoplasmonics, which ushered in remarkable technical innovations accelerated amplification DNA quantitative reverse transcription polymerase chain reaction. Finally, photothermal therapy have recently completed clinical trials results prostate cancer, will inevitably lead implementation number diseases future. Within this review, we offer survey latest advancements burgeoning field keen emphasis on its transformative within realm biosciences.

Language: Английский

Citations

16
Bridging the gaps in cancer photothermal therapy through the intersection of nanotechnology and cell membrane coating DOI
Shumin Yang, Huachun Pan, Blassan P. George

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149641 - 149641

Published: Feb. 15, 2024

Language: Английский

Citations

16
Integrated Copper Nanomaterials‐Decorated Microsphere Photothermal Platform for Comprehensive Melanoma Treatment DOI Creative Commons
Xinyi Zhang, Mengya Zhang,

Hengqing Cui

et al.

Small Structures, Journal Year: 2024, Volume and Issue: 5(6)

Published: April 1, 2024

Patients who undergo resection for melanoma face challenges, such as delayed healing and radiation dermatitis. Moreover, incomplete tumor is a key factor contributing to poor prognosis increased recurrence rates. However, therapeutic platform that can effectively prevent promote wound remains challenge. Hence, pioneering approach presented using melanoma‐derived cancer cell membrane (CM) antigen encapsulate copper (Cu)‐based metal‐organic framework (MOF) nanomaterials fabricate termed MOF@CM. Then MOF@CM adsorbed onto polydopamine (PDA)‐modified poly lactic‐co‐glycolic acid (PLGA) porous microspheres (PLGA/PDA) develop the nanomaterials‐decorated PLGA/PDA‐CCM (PLGA/PDA loaded with CM‐coated MOF). It exerts homologous targeting photothermal effects, inducing immunogenic death. Simultaneously, sustained release of shows enhanced presentation in dendritic cells (DCs) help CpG, induces DC maturation activated immune responses, acting an effective vaccine recurrence. The harnesses combined advantages local thermal effect presence Cu‐based MOF, which endow antibacterial properties stimulate angiogenesis, thereby facilitating mitigating This integrated microsphere treatment represents promising strategy addressing melanoma.

Language: Английский

Citations

13
Innovation applications of MXenes in biomedicine DOI
Ali Mohammad Amani, Lobat Tayebi, Ehsan Vafa

et al.

Materials Today Communications, Journal Year: 2024, Volume and Issue: 40, P. 109929 - 109929

Published: July 23, 2024

Language: Английский

Citations

13
Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy DOI
Ke Ma,

Kezheng Chen,

Sheng‐Lin Qiao

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: 24(4)

Published: March 19, 2024

Abstract Layered double hydroxides (LDH) are a class of functional anionic clays that typically consist orthorhombic arrays metal with anions sandwiched between the layers. Due to their unique properties, including high chemical stability, good biocompatibility, controlled drug loading, and enhanced bioavailability, LDHs have many potential applications in medical field. Especially fields bioimaging tumor therapy. This paper reviews research progress nanocomposites field imaging First, structure advantages LDH discussed. Then, several commonly used methods for preparation presented, co‐precipitation, hydrothermal ion exchange methods. Subsequently, recent advances layered cancer therapy highlighted. Finally, based on current research, we summaries prospects challenges diagnosis

Language: Английский

Citations

11
Mesoporous Silica Nanoparticles as an Ideal Platform for Cancer Immunotherapy: Recent Advances and Future Directions. DOI Creative Commons

Varsha Godakhindi,

Mubin Tarannum,

Sudip Kumar Dam

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)

Published: April 23, 2024

Abstract Cancer immunotherapy recently transforms the traditional approaches against various cancer malignancies. Immunotherapy includes systemic and local treatments to enhance immune responses involves strategies such as checkpoints, vaccines, modulatory agents, mimetic antigen‐presenting cells, adoptive cell therapy. Despite promising results, these still suffer from several limitations including lack of precise delivery immune‐modulatory agents target cells off‐target toxicity, among others, that can be overcome using nanotechnology. Mesoporous silica nanoparticles (MSNs) are investigated improve aspects attributed advantageous structural features this nanomaterial. MSNs engineered alter their properties size, shape, porosity, surface functionality, adjuvanticity. This review explores immunological use vehicles for immune‐adjuvants, (APCs). The also details current remodel tumor microenvironment positively reciprocate toward anti‐tumor in combination with other therapies photodynamic/thermal therapeutic effect cancer. Last, present demands future scenarios discussed.

Language: Английский

Citations

11
Nanoparticle-mediated thermal Cancer therapies: Strategies to improve clinical translatability DOI Creative Commons
Martin Bravo, Beatrice Fortuni, Paul Mulvaney

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 372, P. 751 - 777

Published: July 4, 2024

Despite significant advances, cancer remains a leading global cause of death. Current therapies often fail due to incomplete tumor removal and nonspecific targeting, spurring interest in alternative treatments. Hyperthermia, which uses elevated temperatures kill cells or boost their sensitivity radio/chemotherapy, has emerged as promising alternative. Recent advancements employ nanoparticles (NPs) heat mediators for selective cell destruction, minimizing damage healthy tissues. This approach, known NP hyperthermia, falls into two categories: photothermal (PTT) magnetothermal (MTT). PTT utilizes NPs that convert light heat, while MTT magnetic activated by alternating fields (AMF), both achieving localized damage. These methods offer advantages like precise minimal invasiveness, reduced systemic toxicity. However, the efficacy hyperthermia depends on many factors, particular, properties, microenvironment (TME), TME-NP interactions. Optimizing this treatment requires accurate monitoring strategies, such nanothermometry biologically relevant screening models can better mimic physiological features human body. review explores state-of-the-art NP-mediated discussing available nanomaterials, strengths weaknesses, characterization methods, future directions. Our particular focus lies preclinical techniques, providing an updated perspective relevance journey towards clinical trials.

Language: Английский

Citations

11
The future of plant based green carbon dots as cancer Nanomedicine: From current progress to future Perspectives and beyond DOI Creative Commons
Hui Jing Hong, Ali A. Shati, Mohammad Y. Alfaifi

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 1, 2024

The emergence of carbon dots (CDs) as anticancer agents had sparked a transformation in cancer research and treatment strategies. These fluorescent CDs, initially introduced the early 2000 s, possess exceptional biocompatibility, tunable fluorescence, surface modification capabilities, positioning them promising tools biomedical applications.

Language: Английский

Citations

10