Recent advances and challenges in metal-based antimicrobial materials: a review of strategies to combat antibiotic resistance DOI Creative Commons
Chuanda Zhu,

Zhenli Diao,

Yuanyuan Yang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 9, 2025

Despite the availability of a series classical antibiotic drugs, bacterial infections continue to represent significant and urgent threat global human health. The emergence drug-resistant bacteria slow pace development have rendered current treatment methods inadequate in meeting clinical demands infections. Consequently, there is an increasingly vital need for safe, efficient, alternative novel antimicrobial agents medical healthcare field. Over past five years, has been notable expansion field nanomedicine with regard prevention control infectious diseases. objective this article provide comprehensive review latest research developments metal nanomaterials therapy. We begin by delineating gravity infection crisis, subsequently undertaking examination potential mechanisms through which nanoparticles may combat specific applications these diverse In conclusion, we eagerly anticipate future directions believe that continuous technological advancements innovations, will make even more outstanding contributions safeguarding health well-being.

Language: Английский

Supramolecular Coordination Complexes for Synergistic Cancer Therapy DOI
Yang Li, Feihe Huang, Peter J. Stang

et al.

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(8), P. 1174 - 1187

Published: April 1, 2024

ConspectusSupramolecular coordination complexes (SCCs) are predictable and size-tunable supramolecular self-assemblies constructed through directional bonds between readily available organic ligands metallic receptors. Based on planar 3D structures, SCCs can be mainly divided into two categories: metallacycles (e.g., rhomboidal, triangular, rectangular, hexagonal) metallacages tetrahedral, hexahedral, dodecahedral). The enable the efficient formation of with well-defined architectures geometries. exhibit several advantages, including good directionality, strong interaction force, tunable modularity, solution processability, making them highly attractive for biomedical applications, especially in cellular imaging cancer therapy. Compared their molecular precursors, demonstrate enhanced uptake a strengthened tumor accumulation effect, owing to inherently charged structures. These properties chemotherapeutic potential inherent platinum have promoted widespread application antitumor Furthermore, defined structures SCCs, achieved via design modification assembly elements introduction different functional groups, combat malignant tumors multipronged treatment modalities. Because development cancer-treatment methodologies integrated clinics has evolved from single-modality chemotherapy synergistic multimodal therapy, therapy is crucial. While some pioneering reviews explored bioapplications often categorized by specific function or focusing metal ligand types, comprehensive exploration multifunctionality critical gap current literature.In this Account, we focus platinum-based applications other metals, such as Pd-, Rh-, Ru-, Ir-based been Therrien Casini et al., garnered significant interest, unique advantages which enhance efficacy, considered prominent candidates therapies desirable properties, potent activity, exceptionally low systemic toxicity, active tumor-targeting ability, uptake. diverse diagnostic therapeutic modalities chemotherapy, photothermal photodynamic therapy) single platform based Consequently, herein, summarize our recent research particular emphasis cooperative interplay methods. In Conclusions section, present key advancements basis findings propose future directions that may significantly impact field.

Language: Английский

Citations

32
Nanozybiotics: Advancing Antimicrobial Strategies Through Biomimetic Mechanisms DOI
Caiyu Zhou, Qian Wang,

Haolin Cao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)

Published: June 14, 2024

Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies proving inadequate against the swift evolution microbial resistance. Therefore, there is an urgent need develop novel with mechanisms distinct from those existing antibiotics. Nanozybiotics, which nanozyme-based antimicrobials, mimic catalytic action lysosomal enzymes in innate immune cells kill infectious pathogens. This review reinforces concept nanozymes provides comprehensive summary recent research advancements on potential candidates. Initially, nanozybiotics categorized based their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting superior combating then discusses progress treating infections, confirming as translational nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, protective clothing, also considered. Finally, current challenges future prospects nanozybiotic-related products explored, emphasizing design capabilities for applications.

Language: Английский

Citations

20
Antimicrobial Phenolic Materials: From Assembly to Function DOI Creative Commons
Wanjun Xu, Zhixing Lin, Christina Cortez‐Jugo

et al.

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.

Language: Английский

Citations

5
Copper‐Based Nanozymes: Potential Therapies for Infectious Wounds DOI Open Access
Haojie Ge, Min Wang,

Xiaolong Wei

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Bacterial infections are a significant obstacle to the healing of acute and chronic wounds, such as diabetic ulcers burn injuries. Traditional antibiotics primary treatment for bacterial infections, but they present issues antibiotic resistance, limited efficacy, potential side effects. This challenge leads exploration nanozymes alternative therapeutic agents. Nanozymes nanomaterials with enzyme‐like activities. Owing their low production costs, high stability, scalability, multifunctionality, have emerged prominent focus in antimicrobial research. Among various types nanozymes, metal‐based offer several benefits, including broad‐spectrum activity robust catalytic properties. Specifically, copper‐based (CuNZs) shown considerable promoting wound healing. They exhibit strong effects, reduce inflammation, enhance tissue regeneration, making them highly advantageous use care. review describes dual functions CuNZs combating infection facilitating repair. Recent advancements design synthesis CuNZs, evaluating promotion, biosafety both vitro vivo on basis core components, critically important.

Language: Английский

Citations

4
Copper-based nanomaterials for the treatment of bacteria-infected wounds: material classification, strategies and mechanisms DOI
Wenqi Wang, Peng Gao,

Hengshuo Gui

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216205 - 216205

Published: Sept. 11, 2024

Language: Английский

Citations

18
Innovative Bio‐based Hydrogel Microspheres Micro‐Cage for Neutrophil Extracellular Traps Scavenging in Diabetic Wound Healing DOI Creative Commons

Yongqiang Xiao,

Tao Ding, Fang He

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(21)

Published: April 6, 2024

Abstract Neutrophil extracellular traps (NETs) seriously impede diabetic wound healing. The disruption or scavenging of NETs using deoxyribonuclease (DNase) cationic nanoparticles has been limited by liberating trapped bacteria, short half‐life, potential cytotoxicity. In this study, a positive correlation between the level in exudation and severity inflammation patients is established. Novel bio‐based hydrogel microspheres ‘micro‐cage’, termed mPDA‐PEI@GelMA, engineered integrating methylacrylyl gelatin (GelMA) with polyethyleneimine (PEI)‐functionalized mesoporous polydopamine (mPDA). This unique ‘micro‐cage’ construct designed to non‐contact scavenge surface, minimizing biological toxicity ensuring high biosafety. are introduced into along exudation, mPDA‐PEI immobilizes them inside through strong binding affinity cfDNA web structure. findings demonstrate that mPDA‐PEI@GelMA effectively mitigates pro‐inflammatory responses associated wounds both vivo vitro. work introduces novel nanoparticle strategy enhance healing processes, benefits clinical applications.

Language: Английский

Citations

17
Plasmonic Supramolecular Nanozyme‐Based Bio‐Cockleburs for Synergistic Therapy of Infected Diabetic Wounds DOI Open Access
Xin Wang,

Xudong Qin,

Yi Liu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Abstract Diabetic wounds are a major devastating complication of diabetes due to hyperglycemia, bacterial invasion, and persistent inflammation, the current antibiotic treatments can lead emergence multidrug‐resistant bacteria. Herein, bimetallic nanozyme‐based biomimetic bio‐cocklebur (GNR@CeO 2 @GNPs) is designed synthesized for diabetic wound management by depositing spiky ceria (CeO ) shells gold nanoparticles (GNPs) on nanorod (GNR) nanoantenna. The plasmonic‐enhanced nanozyme catalysis self‐cascade reaction properties simultaneously boost two‐step enzyme‐mimicking catalytic activity GNR@CeO @GNPs, leading significant improvement in overall therapeutic efficacy rather than mere additive effects. Under glucose activation 808 nm laser irradiation, @GNPs material captures photons promotes transfer hot electrons from GNR GNPs into CeO , realizing “butterfly effect” consuming local glucose, overcoming limited antibacterial efficiency an individual PTT modality, providing substantial reactive oxygen species. In vitro vivo experiments demonstrate material's exceptional antibiofilm against Gram‐negative Gram‐positive bacteria, which reduce promote collagen deposition, facilitate angiogenesis, thereby accelerating healing. This study provides promising new strategy develop nanozymes with cascade mode antibiotic‐free synergistic treatment infected wounds.

Language: Английский

Citations

17
Advancements in nanozymes research for the management of chronic wounds DOI

Duoduo Chen,

Guoxin Tan,

Shujian Tian

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157299 - 157299

Published: Nov. 1, 2024

Language: Английский

Citations

10
Facile Fabrication of Injectable Multifunctional Hydrogels Based on Gallium‐Polyphenol Networks with Superior Antibacterial Activity for Promoting Infected Wound Healing DOI Open Access

Minglang Zou,

Cuiping Chen, Ming-Da Wang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Multifunctional hydrogels hold significant promise for promoting the healing of infected wounds but often fall short in inhibiting antibiotic-resistant pathogens, and their clinical translation is limited by complex preparation processes high costs. In this study, a multifunctional hydrogel developed combining metal-phenolic networks (MPNs) formed tannic acid (TA) gallium ions (Ga3⁺) with chitosan (CS) through simple one-step method. The resulting CS-TA-Ga3⁺ (CTG) cost-effective exhibits desirable properties, including injectability, self-healing, pH responsiveness, hemostasis, antioxidant, anti-inflammatory, antibacterial activities. Importantly, CTG are effective against pathogens due to unique mechanism Ga3⁺. vivo studies demonstrate that promotes follicle formation collagen deposition, accelerating blood loss, suppressing bacterial growth, modulating inflammatory microenvironment. These findings highlight hydrogel's potential as an advanced translational dressing enhancing wounds.

Language: Английский

Citations

2
Recent advances in nanomaterials and their mechanisms for infected wounds management DOI Creative Commons
Jianping Zhu, Fan Xia,

Shuaifei Wang

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101553 - 101553

Published: Feb. 5, 2025

Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient

Language: Английский

Citations

2