Recent advances in spatio-temporally controllable systems for management of glioma DOI Creative Commons
Huiwen Zhang,

Wanqi Zhu,

Wei Pan

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(5), P. 100954 - 100954

Published: Aug. 23, 2024

Malignant glioma remains one of the most aggressive intracranial tumors with devastating clinical outcomes despite great advances in conventional treatment approaches, including surgery and chemotherapy. Spatio-temporally controllable approaches to are now being actively investigated due preponderance, spatio-temporal adjustability, minimally invasive, repetitive properties, etc. External stimuli can be readily controlled by adjusting site density exert cytotoxic on tissue avoid undesired injury normal tissues. It is worth noting that removability external allows for on-demand treatment, which effectively reduces occurrence side effects. In this review, we highlight recent advancements drug delivery systems spatio-temporally treatments glioma, focusing mechanisms design principles sensitizers utilized these therapies. Moreover, potential challenges regarding therapy also described, aiming provide insights into future field their applications.

Language: Английский

Emerging nanoplatforms towards microenvironment-responsive glioma therapy DOI

Nigam Sekhar Tripathy,

Liza Sahoo,

Safal Kumar Paikray

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(2)

Published: Jan. 15, 2025

Language: Английский

Citations

1
Biomimetic Nanoparticle Based Targeted mRNA Vaccine Delivery as a Novel Therapy for Glioblastoma Multiforme DOI
Tanvir Ahmed,

Kazi Tasnuva Alam

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(3)

Published: Feb. 21, 2025

Language: Английский

Citations

1
Stimuli-Responsive Polymeric Nanocarriers Accelerate On-Demand Drug Release to Combat Glioblastoma DOI
Muhammad Ismail,

Yibin Wang,

Yundong Li

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Glioblastoma multiforme (GBM) is a highly malignant brain tumor with poor prognosis and limited treatment options. Drug delivery by stimuli-responsive nanocarriers holds great promise for improving the modalities of GBM. At beginning review, we highlighted stimuli-active polymeric carrying therapies that potentially boost anti-GBM responses employing endogenous (pH, redox, hypoxia, enzyme) or exogenous stimuli (light, ultrasonic, magnetic, temperature, radiation) as triggers controlled drug release mainly via hydrophobic/hydrophilic transition, degradability, ionizability, etc. Modifying these target ligands further enhanced their capacity to traverse blood-brain barrier (BBB) preferentially accumulate in glioma cells. These unique features lead more effective cancer minimal adverse reactions superior therapeutic outcomes. Finally, review summarizes existing difficulties future prospects treating Overall, this offers theoretical guidelines developing intelligent versatile facilitate precise GBM clinical settings.

Language: Английский

Citations

8
Plant-Derived Exosomes in Therapeutic Nanomedicine, Paving the Path Toward Precision Medicine DOI
Min Zheng, Vivek P. Chavda, Dixa A. Vaghela

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156087 - 156087

Published: Sept. 26, 2024

Language: Английский

Citations

5
Biomimetic nanoparticle-driven strategies for targeted drug delivery in glioblastoma DOI Creative Commons
Khushi N. Panchal, Srinivas Mutalik, Jyothsna Manikkath

et al.

Journal of Nanoparticle Research, Journal Year: 2024, Volume and Issue: 26(8)

Published: Aug. 1, 2024

Abstract Glioblastoma (GBM), the most prevalent primary brain tumor in adults, remains highly challenging due to its invasive nature, limited treatment effectiveness, and short median survival durations. Standard of care includes surgery, radiation, chemotherapy, treating fields; however, there has been little improvement rates. Biomimetic nanoparticles (NPs), coated with cell membranes endogenous components, have immense potential for improving chemotherapy GBM, by imitating cellular architecture eluding immune clearance. With more individualized efficient drug delivery, immunotherapeutic approaches biomimetic NPs may increase patient This article summarizes main research on GBM therapy, focusing classification, mechanisms, advantages, challenges, along advancements development vaccines.

Language: Английский

Citations

3
The anti-glypican 1 AT101 antibody as targeting agent to effectively deliver chitosan nanobubbles to glioblastoma cells DOI
Federica Di Cintio, Monica Argenziano, Anna Scomparin

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Dec. 2, 2024

Background Recently, we developed AT101, an IgM-class mouse monoclonal antibody directed against glypican-1 (GPC1), a proteoglycan that can be considered as useful target for glioblastoma multiforme (GBM) treatment being specifically and highly expressed on GBM cell surface. Here, proposed the use of AT101 targeting agent in drug delivery nanoplatfom to effectively deliver chitosan nanobubbles (NBs) treatment.

Language: Английский

Citations

2
Precision Population Cancer Medicine in Brain Tumors: A Potential Roadmap to Improve Outcomes and Strategize the Steps to Bring Interdisciplinary Interventions DOI Open Access
Umesh Velu, Anshul Singh,

Roselin Nittala

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 12, 2024

Brain tumors, a significant health burden, rank as the second leading cause of cancer among adolescents and young adults eighth most common in older adults. Despite treatment advances, outcomes for many brain tumor types, especially glioblastoma multiforme (GBM), remain poor. Precision population medicine (PPCM) offers promising avenues improving management. This comprehensive review delves into current landscape diagnosis treatment, with primary focus on potential PPCM to enhance care. The explores several key areas where approaches show promise. In genetics molecular biology, genetic heterogeneity tumors poses challenges opportunities targeted therapies. Understanding patterns can guide strategies improve prognostication. Epigenetic modifications are crucial development progression. Deoxyribonucleic acid (DNA) methylation patterns, particularly O6-methylguanine-DNA methyltransferase (MGMT) gene promoter, serve essential biomarkers response prognosis GBM. Targeting epigenetic mechanisms could lead novel therapeutic approaches. Non-invasive liquid biopsy techniques diagnosis, monitoring, prognostication tumors. Analysis circulating DNA microRNAs may provide valuable information about characteristics response. Advanced imaging techniques, including radiomics radiogenomics, combined artificial intelligence (AI) algorithms, enhancing detection, characterization, planning. These technologies contribute more personalized addition, emerging nanotherapeutic platforms, which involve use nanoparticles deliver drugs directly theranostic approaches, combine therapy diagnostics single platform, offer new possibilities drug delivery real-time monitoring also addresses socioeconomic demographic factors influencing incidence outcomes. It highlights stark disparities care access survival rates different racial ethnic groups, emphasizing urgent need address these inequities. Challenges implementing include blood-brain barrier, limits delivery, extensive clinical trials validate authors stress importance interdisciplinary collaboration data sharing advance field, making audience feel united part larger team. While holds great promise, emphasizes that it should complement, not replace, population-level interventions standard-of-care treatments. advocate balanced approach leverages cutting-edge while ensuring broad effective conclusion, represents powerful tool fight against offering targeted, effective, less toxic However, realizing its full will require ongoing research, validation, policy interactions access.

Language: Английский

Citations

1
Material informatics-driven insights into brain cancer nanocarriers: A bibliometric comparison of PLGA vs. liposomes DOI Creative Commons

Brilly Andro Makalew,

Syauqi Abdurrahman Abrori

OpenNano, Journal Year: 2024, Volume and Issue: 21, P. 100225 - 100225

Published: Dec. 11, 2024

Language: Английский

Citations

1
Recent advances in spatio-temporally controllable systems for management of glioma DOI Creative Commons
Huiwen Zhang,

Wanqi Zhu,

Wei Pan

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(5), P. 100954 - 100954

Published: Aug. 23, 2024

Malignant glioma remains one of the most aggressive intracranial tumors with devastating clinical outcomes despite great advances in conventional treatment approaches, including surgery and chemotherapy. Spatio-temporally controllable approaches to are now being actively investigated due preponderance, spatio-temporal adjustability, minimally invasive, repetitive properties, etc. External stimuli can be readily controlled by adjusting site density exert cytotoxic on tissue avoid undesired injury normal tissues. It is worth noting that removability external allows for on-demand treatment, which effectively reduces occurrence side effects. In this review, we highlight recent advancements drug delivery systems spatio-temporally treatments glioma, focusing mechanisms design principles sensitizers utilized these therapies. Moreover, potential challenges regarding therapy also described, aiming provide insights into future field their applications.

Language: Английский

Citations

0