OPTIMIZATION OF PROCESS PARAMETERS FOR ENHANCING THE SKIN PERMEATION EFFICIENCY OF NISOLDIPINE LOADED ULTRA DEFORMABLE VESICLES IN TRANSDERMAL PATCHES DOI Open Access

D. Maheswara Reddy,

M. Mothilal

International Journal of Applied Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 133 - 146

Published: Nov. 7, 2024

Objective: The study aimed to address the limitations of oral delivery and enhance bioavailability nisoldipine (NSD) through development transferosomal transdermal patches containing ultra-deformable transferosomes. Methods: NSD, known for its low adverse effects, was encapsulated in transferosomes using a thin film hydration method. 17 formulations were made Box Behnken Design, varying Dipalmitoylphosphatidylcholine (DPPC), span-80, stirring speed, evaluated vesicle size, Polydispersity Index (PDI), Entrapment Efficiency (EE%). optimal formulation, selected based on these parameters, combined into Transdermal Patches (TPs). underwent extensive testing physicochemical properties, vitro ex-vivo permeation, skin irritancy. Results: results showed with Vesicle Sizes (VS) ranging from 124±2.25 400±1.55 nm EE% 52.88±0.23 90.01±1.58%, Zeta Potentials (ZP) between-48 to-20 mV. patch thickness (0.66±0.02 mm) weight per square inch (382.1±1.69 mg) consistent manufacturing, while Water Vapor Transmission Rate (WVT) (1.54±0.01g/m²/24h), moisture content (1.07±0.01%), regulated absorption (3.78±0.01%) maintained formulation stability. In permeation indicated superior drug (NP) compared plain (NP-N), directly proportional PEG-400 concentration. Additionally, found be free irritation. Conclusion: optimized Niosoldipine (NP-3) composition displays good folding endurance (FE) 97.67±0.47, required systems, successfully allows (DP) at 86.39±2.64% short timescale. Hence, concludes that NSD offer promising approach effective delivery, potentially improving hypertension management by providing controlled prolonged release.

Language: Английский

Polymeric Microneedle Drug Delivery Systems: Mechanisms of Treatment, Material Properties, and Clinical Applications—A Comprehensive Review DOI Open Access
Yun Liu,

Ruiyue Mao,

Shijia Han

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2568 - 2568

Published: Sept. 11, 2024

Our comprehensive review plunges into the cutting-edge advancements of polymeric microneedle drug delivery systems, underscoring their transformative potential in realm transdermal administration. scrutiny centers on substrate materials pivotal for construction and core properties that dictate efficacy. We delve distinctive interplay between microneedles dermal layers, mechanisms by which this synergy enhances absorption precision targeting. Moreover, we examine acupoint-target organ-ganglion nexus, an innovative strategy steers concentration to specific targets, offering a paradigm medicine. A thorough analysis clinical applications systems is presented, highlighting adaptability impact across spectrum therapeutic domains. This also accentuates systems' promise bolster patient compliance, attributed minimally invasive painless mode delivery. present forward-looking strategies aimed at optimizing stimulation sites amplify benefits. The anticipation set introduction superior biocompatible with advanced mechanical properties, customizing cater specialized demands. In parallel, deliberate safety boosting loading capacities solidifying efficacy microneedle-based therapeutics. summation, role technology contemporary healthcare, charting course future investigative endeavors developmental strides within burgeoning field.

Language: Английский

Citations

4
CBD-Loaded Nanostructured Lipid Carriers: Optimization, Characterization, and Stability DOI Creative Commons
Yang Xie, Peng Li, Dong Fu

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(39), P. 40632 - 40643

Published: Sept. 19, 2024

Cannabidiol (CBD) has demonstrated its potential to enhance depression treatment through various biological pathways. However, the application of CBD is significantly impeded by polymorphic nature, limited water solubility, and hepatic first-pass metabolism. To improve chemical stability nanostructured lipid carriers loaded with (CBD-NLCs) were developed using a hot-melt emulsification method optimized response surface methodology (RSM). The process parameters four-factor three-level Box-Behnken experimental design consisting 29 experiments. CBD-NLCs formulated characterized, demonstrating desirable properties, including mean particle size 54.33 nm, PDI value 0.118, zeta -29.7 mV, an impressive encapsulation efficiency rate 87.58%. nanoparticles found possess approximately spherical shape, as revealed scanning transmission electron microscopy. studies have that effectively mitigated photodegradation exhibited stable behavior for 42 days when stored. displayed biphasic release profile characterized initial burst (over 50% released within 20 min) followed subsequent gradual sustained release, aligned first-order kinetics Fickian diffusion. These findings demonstrate suitability this formulation carrier in food fortification pharmaceutical applications.

Language: Английский

Citations

3
Mesoporous polydopamine (MPDA)-based drug delivery system for oral chemo-photothermal combinational therapy of orthotopic colon cancer DOI

Donghao Gu,

Yun Liu,

Liu L

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136618 - 136618

Published: Oct. 16, 2024

Language: Английский

Citations

2
Exploring the Potential of Nonpsychoactive Cannabinoids in the Development of Materials for Biomedical and Sports Applications DOI

Dulexy Solano-Orrala,

Dennis A. Silva-Cullishpuma,

Eliana Díaz-Cruces

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

This Perspective explores the potential of nonpsychoactive cannabinoids (NPCs) such as CBD, CBG, CBC, and CBN in developing innovative biomaterials for biomedical sports applications. It examines their physicochemical properties, anti-inflammatory, analgesic, neuroprotective effects, integration into various hydrogels, sponges, films, scaffolds. also discusses current challenges standardizing formulations, understanding long-term intrinsical regulatory landscapes. Further, it promising applications NPC-loaded materials bone regeneration, wound management, drug delivery systems, emphasizing improved biocompatibility, mechanical therapeutic efficacy demonstrated

Language: Английский

Citations

1
OPTIMIZATION OF PROCESS PARAMETERS FOR ENHANCING THE SKIN PERMEATION EFFICIENCY OF NISOLDIPINE LOADED ULTRA DEFORMABLE VESICLES IN TRANSDERMAL PATCHES DOI Open Access

D. Maheswara Reddy,

M. Mothilal

International Journal of Applied Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 133 - 146

Published: Nov. 7, 2024

Objective: The study aimed to address the limitations of oral delivery and enhance bioavailability nisoldipine (NSD) through development transferosomal transdermal patches containing ultra-deformable transferosomes. Methods: NSD, known for its low adverse effects, was encapsulated in transferosomes using a thin film hydration method. 17 formulations were made Box Behnken Design, varying Dipalmitoylphosphatidylcholine (DPPC), span-80, stirring speed, evaluated vesicle size, Polydispersity Index (PDI), Entrapment Efficiency (EE%). optimal formulation, selected based on these parameters, combined into Transdermal Patches (TPs). underwent extensive testing physicochemical properties, vitro ex-vivo permeation, skin irritancy. Results: results showed with Vesicle Sizes (VS) ranging from 124±2.25 400±1.55 nm EE% 52.88±0.23 90.01±1.58%, Zeta Potentials (ZP) between-48 to-20 mV. patch thickness (0.66±0.02 mm) weight per square inch (382.1±1.69 mg) consistent manufacturing, while Water Vapor Transmission Rate (WVT) (1.54±0.01g/m²/24h), moisture content (1.07±0.01%), regulated absorption (3.78±0.01%) maintained formulation stability. In permeation indicated superior drug (NP) compared plain (NP-N), directly proportional PEG-400 concentration. Additionally, found be free irritation. Conclusion: optimized Niosoldipine (NP-3) composition displays good folding endurance (FE) 97.67±0.47, required systems, successfully allows (DP) at 86.39±2.64% short timescale. Hence, concludes that NSD offer promising approach effective delivery, potentially improving hypertension management by providing controlled prolonged release.

Language: Английский

Citations

0