Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(47), P. 11319 - 11334
Published: Jan. 1, 2023
A CuS–curcumin hybrid hydrogel with good biocompatibility, NIR-enhanced antibacterial, antioxidant, anti-inflammatory, and angiogenesis properties has been developed for infected wound healing.
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129300 - 129300
Published: Jan. 11, 2024
Language: Английский
Citations
28
Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 62 - 82
Published: Feb. 28, 2024
Tendon-bone interface injuries pose a significant challenge in tissue regeneration, necessitating innovative approaches. Hydrogels with integrated supportive features and controlled release of therapeutic agents have emerged as promising candidates for the treatment such injuries. In this study, we aimed to develop temperature-sensitive composite hydrogel capable providing sustained magnesium ions (Mg2+). We synthesized magnesium-Procyanidin coordinated metal polyphenol nanoparticles (Mg-PC) through self-assembly process them into two-component hydrogel. The was composed dopamine-modified hyaluronic acid (Dop-HA) F127. To ensure mitigate "burst release" effect Mg2+, covalently crosslinked Mg-PC coordination bonds catechol moiety within This crosslinking strategy extended window Mg2+ concentrations up 56 days. resulting (Mg-PC@Dop-HA/F127) exhibited favorable properties, including injectability, thermosensitivity shape adaptability, making it suitable injection adaptation irregularly shaped supraspinatus implantation sites. Furthermore, Procyanidins, which attracted mesenchymal stem progenitor cells, alleviated inflammation, promoted macrophage polarization towards M2 phenotype. Additionally, enhanced collagen synthesis mineralization, facilitating repair tendon-bone interface. By incorporating multilevel phenolic networks (MPN) control ion release, these hybridized hydrogels can be customized various biomedical applications.
Language: Английский
Citations
25
Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 1 - 30
Published: April 23, 2024
Characterized by their pivotal roles in cell-to-cell communication, cell proliferation, and immune regulation during tissue repair, exosomes have emerged as a promising avenue for "cell-free therapy" clinical applications. Hydrogels, possessing commendable biocompatibility, degradability, adjustability, physical properties akin to biological tissues, also found extensive utility engineering regenerative repair. The synergistic combination of hydrogels holds the potential not only enhance efficiency but collaboratively advance repair process. This review has summarized advancements made over past decade research hydrogel-exosome systems regenerating various tissues including skin, bone, cartilage, nerves tendons, with focus on methods encapsulating releasing within hydrogels. It critically examined gaps limitations current research, whilst proposed future directions applications this innovative approach.
Language: Английский
Citations
22
Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 43, P. 102503 - 102503
Published: Jan. 1, 2025
Language: Английский
Citations
2
Theranostics, Journal Year: 2024, Volume and Issue: 14(11), P. 4198 - 4217
Published: Jan. 1, 2024
The utilization of extracellular vesicles (EVs) in wound healing has been well-documented.However, the direct administration free EVs via subcutaneous injection at sites may result rapid dissipation bioactive components and diminished therapeutic efficacy.Functionalized hydrogels provide effective protection, as well ensure sustained release bioactivity during process, making them an ideal candidate material for delivering EVs.In this review, we introduce mechanisms by which accelerate healing, then elaborate on construction strategies engineered EVs.Subsequently, discuss synthesis application delivery systems to enhance complicated healing.Furthermore, face wounds, functionalized with specific microenvironment regulation capabilities, such antimicrobial, anti-inflammatory, immune regulation, used loading EVs, potential approaches addressing these challenges.Ultimately, deliberate future trajectories outlooks, offering a fresh viewpoint advancement artificial intelligence (AI)-energized materials 3D bio-printed multifunctional hydrogel-based dressings biomedical applications.
Language: Английский
Citations
15
Small Methods, Journal Year: 2024, Volume and Issue: 8(9)
Published: Feb. 25, 2024
Chitin and chitosan-based bioink for 3D-printed flexible electronics have tremendous potential innovation in healthcare, agriculture, the environment, industry. This biomaterial is suitable 3D printing because it highly stretchable, super-flexible, affordable, ultrathin, lightweight. Owing to its ease of use, on-demand manufacturing, accurate regulated deposition, versatility with soft functional materials, has revolutionized free-form construction end-user customization. study examined employing chitin bioinks build electronic devices optimize formulation, parameters, postprocessing processes improve mechanical electrical properties. The exploration bioelectronics will open new avenues materials numerous industrial applications.
Language: Английский
Citations
10
View, Journal Year: 2024, Volume and Issue: 5(4)
Published: July 18, 2024
Abstract With the aging and obesity era, increasing incidence of diabetes diabetic complications, especially non‐healing wounds, imposes a serious economic burden on both patients society. The complex microenvironments, including hyperglycemia, bacterial infection, ischemia, nerve damage, lead to prolonged inflammation proliferation phase wounds. Mesenchymal stem cell‐derived small extracellular vesicles (MSC‐sEVs), which contain rich variety therapeutic molecules, have been chased for decades because their potential roles in cellular communication, tissue regeneration, drug delivery. As powerful tools controlled‐sustained release sEVs, biocompatible hydrogels applied wide range biomedical applications. Herein, we first summarize pathological features such as angiopathy, neuropathy, immune cell dysfunction. Then, discuss biological properties, performance, stability pure MSC‐sEVs. After that, components, application patterns, responsiveness hydrogels. Next, loading avenues MSC‐sEVs into hydrogel, behaviors sEVs from hydrogels, influence crosslinking method hydrogel‐sEV composites. Finally, provide an overview current applications loaded with novel cell‐free engineering system managing wounds propose critical unsolved issues. This review is expected meaningful guidance developing wound management.
Language: Английский
Citations
10
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 111 - 125
Published: May 24, 2024
Language: Английский
Citations
6
Tissue Engineering Part A, Journal Year: 2024, Volume and Issue: 30(13-14), P. 387 - 408
Published: Jan. 11, 2024
Bioprinting describes the printing of biomaterials and cell-laden or cell-free hydrogels with various combinations embedded bioactive molecules. It encompasses precise patterning cells to create scaffolds for different biomedical needs. There are many requirements that bioprinting face, it is ultimately interplay between scaffold's structure, properties, processing, performance will lead its successful translation. Among essential properties must possess—adequate appropriate application-specific chemical, mechanical, biological performance—the mechanical behavior hydrogel-based bioprinted key their stable in vivo at site implantation. Hydrogels typically constitute main scaffold material medium biomolecules very soft, often lack sufficient stability, which reduces printability and, therefore, potential. The aim this review article highlight reinforcement strategies used approaches achieve enhanced stability bioinks printed scaffolds. Enabling robust materials processes creation truly complex remarkable structures could accelerate application smart, functional settings. a powerful tool fabrication 3D applications. has gained tremendous attention recent years, bioink library expanding include more combinations. From practical perspective, need be considered, such as structure's performances. these, constructs critical translation into clinic. explore stabilization structures.
Language: Английский
Citations
4
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 252 - 252
Published: Feb. 8, 2024
Infectious and Parasitic Diseases (IPD) remain a challenge for medicine due to several interconnected reasons, such as antimicrobial resistance (AMR). American tegumentary leishmaniasis (ATL) is an overlooked IPD causing persistent skin ulcers that are challenging heal, resulting in disfiguring scars. Moreover, it has the potential extend from mucous membranes of nose, mouth, throat both humans various animals. Given limited effectiveness AMR current drugs, exploration new substances emerged promising alternative ATL treatment. Arrabidaea brachypoda (DC). Bureau native Brazilian plant rich dimeric flavonoids, including Brachydin (BRA), which displays activity, but still little been explored regarding development therapeutic formulations. In this work, we present design low-cost liquid formulation based on use Pluronic F127 encapsulation high BRA concentration (LF-B500). The characterization techniques revealed BRA-loaded micelles well-stabilized unusual worm-like form. vitro cytotoxicity assay demonstrated LF-B500 was non-toxic macrophages efficient inactivation forms Leishmania amazonensis promastigotes with IC50 16.06 µg/mL. results opened perspective formulation-based natural products
Language: Английский
Citations
4