Emerging Applications of Nanoparticles in the Diagnosis and Treatment of Breast Cancer

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(7), P. 723 - 723

Published: July 4, 2024

Breast cancer remains the most prevalent among women worldwide, driving urgent need for innovative approaches to diagnosis and treatment. This review highlights pivotal role of nanoparticles in revolutionizing breast management through advancements interconnected including targeted therapy, imaging, personalized medicine. Nanoparticles, with their unique physicochemical properties, have shown significant promise addressing current treatment limitations such as drug resistance nonspecific systemic distribution. Applications range from enhancing delivery systems sustained release developing diagnostic tools early precise detection metastases. Moreover, integration into photothermal therapy synergistic use existing treatments, immunotherapy, illustrate transformative potential care. However, journey towards clinical adoption is fraught challenges, chemical feasibility, biodistribution, efficacy, safety concerns, scalability, regulatory hurdles. delves state nanoparticle research, applications diagnosis, obstacles that must be overcome integration.

Language: Английский

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Molecularly Manipulating Pyrazinoquinoxaline Derivatives to Construct NIR-II AIEgens for Multimodal Phototheranostics of Breast Cancer Bone Metastases

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123105 - 123105

Published: Jan. 11, 2025

Language: Английский

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Plant protein-derived anti-breast cancer peptides: sources, therapeutic approaches, mechanisms, and nanoparticle design

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 17, 2025

Breast cancer causes the deaths of approximately 685,000 women annually, posing a severe threat to women's health. Consequently, there is an urgent need for low-cost, low-toxicity and effective therapeutic methods prevent or mitigate breast progression. PDBP are natural, non-toxic, affordable substances have demonstrated excellent anti-breast activities in inhibiting proliferation, migration, invasion, promoting apoptosis both vitro vivo, thus effectively preventing cancer. However, no comprehensive reviews summarizing effects mechanisms on treatment Therefore, this review described inhibitory active peptides from different plant protein sources Additionally, we summarized advantages preparation protein-derived anticancer peptide-encapsulated nanoparticles their This provides scientific basis understanding offers guidance development adjuvants enriched with these peptides.

Language: Английский

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Automatic detecting multiple bone metastases in breast cancer using deep learning based on low-resolution bone scan images

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 6, 2025

Whole-body bone scan (WBS) is usually used as the effective diagnostic method for early-stage and comprehensive metastases of breast cancer. WBS images with cancer metastasis have characteristics low resolution, small foreground, multiple lesions, hindering widespread application deep learning-based models. Automatically detecting a large number densely lesions on low-resolution remains challenge. We aim to develop unified framework based images. propose novel detection detect Considering difficulties feature extraction caused by resolution we innovatively plug-and-play position auxiliary module fusion enhance ability global information extraction. In order accurately in WBS, designed self-attention transformer-based target head. This retrospective study included 512 patients from Peking Union Medical College Hospital. The data type whole-body image. For our study, ratio training set, validation set test about 6:2:2. benchmarks are four representative baselines, SSD, YOLOR, Faster_RCNN_R Scaled-YOLOv4. performance metrics Average Precision (AP), Recall. results obtained through proposed were assessed using Bonferroni-adjusted Wilcoxon rank test. significant level adjusted according different comparisons. conducted extensive experiments ablation studies private dataset public scans West China Hospital validate effectiveness generalization. Experiments evaluate method. First, compared network architectures, AP 55.0 ± 6.4% (95% confidence intervals (CI) 49.9–60.1%, $$p<0.05$$ ), which improved 45.2% SSD baseline 9.8 2% CI 8.1–11.4%). metric recall, achieved average 54.3 4.2% 50.9–57.6%, has recall values 49.01% model 5.2 12.7% 10–21.3%). Second, studies. On dataset, adding head will increase 14.03% (from 33.3 47.6 4.4%) 19.3% 52.6 6.1%), respectively. addition, generalization was also verified BS-80K Extensive experimental demonstrated superiority To best knowledge, work first attempt developing automatic detector considering unique foreground Our tailored can be clinical decision support tool early decision-making metastases.

Language: Английский

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Coconut Oil and Shea Butter as Lipids for the Formulation of Ciprofloxacin-Loaded Nanoparticles

Journal of Pharmaceutical Innovation, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 10, 2025

Language: Английский

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On-site delivery of bioactive nanospheres utilizing lanthanides as crosslinkers and metastasis-inhibiting agents for breast cancer therapy

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113671 - 113671

Published: March 1, 2025

Language: Английский

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Modern Treatment of Skeletal Metastases: Multidisciplinarity and the Concept of Oligometastasis in the Recent Literature

Current Oncology, Journal Year: 2025, Volume and Issue: 32(4), P. 226 - 226

Published: April 11, 2025

Bone metastases are a major concern in cancer management since they significantly contribute to morbidity and mortality. Metastatic lesions, commonly arising from breast, prostate, lung, kidney cancers, affect approximately 25% of patients, leading severe complications such as pain, fractures, neurological deficits. This narrative review explores contemporary approaches bone metastases, emphasizing multidisciplinary strategy the evolving concept oligometastatic disease. Oligometastases, defined by limited metastatic spread (1–5 lesions), offer potential window for curative treatment through aggressive interventions, including stereotactic ablative radiotherapy resection surgery. Tumor boards, integrating systemic therapies with local crucial optimize treatment. Despite promising results, gaps remain defining optimal sequences refining patient selection criteria. Future research should focus on personalized approaches, leveraging biomarkers advanced imaging enhance outcomes quality life patients metastases.

Language: Английский

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Nano-Drug Delivery Systems for Bone Metastases: Targeting the Tumor–Bone Microenvironment

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 603 - 603

Published: May 2, 2025

Bone metastases are a prevalent and debilitating consequence of various cancers, including breast prostate carcinomas, which significantly compromise patient quality life due to pain, fractures, other skeletal-related events (SREs). This review examines the pathophysiology bone metastases, emphasizing role microenvironment in tumor progression through mechanisms such as osteotropism dysregulated remodeling cycle. The primary focus is on emerging nano-drug delivery systems (DDS) designed target improve therapeutic index anticancer agents. Current treatments, mainly comprising bisphosphonates radiotherapy, provide palliative benefits but often have limited efficacy significant side effects. Innovative strategies, bisphosphonate-conjugated nanoparticles targeted therapies that utilize unique marrow niche, explored for their potential enhance drug accumulation at metastatic sites while minimizing systemic toxicity. These approaches include use liposomes, polymeric nanoparticles, inorganic can be functionalized exploit biological barriers within microenvironment. also discusses challenges future directions nano-DDS clinical settings, need multidisciplinary research effectively integrate these technologies into standard care protocols.

Language: Английский

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Transforming bone cancer treatment: a comprehensive review of green-synthesized metal nanoparticles

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 25, 2025

Osteosarcoma (OS), chondrosarcoma (CHS), and Ewing sarcoma (EWS) are the main types of bone cancer (BC). OS is most common BC in this group. It children older people, especially their long bones. Treatments for sarcomas tumors have slowly improved, so researchers began looking into additional alternative approaches to standard therapies. Therefore, ability precisely manipulate metallic nanoparticles (MNPs)' form, size, charge, surface modification makes them very useful treating cancer. However, due biocompatibility possible toxicity MNPs, MNP has limits clinical use BC. green synthesis MNPs achieved by bio-reducing ions, which results creation NPs, using living entities or extracts. Green derived from natural sources provide a secure environmentally responsible solution. Benefits include tailored medicine delivery biocompatibility. reduce damage healthy cells while improving targeting cells. In study, we reviewed how different synthesized methods can help treat various This work usual way making BC, problems with benefits future uses synthetic

Language: Английский

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A Water-Soluble Aggregation-Induced Emission Luminogen for NIR-I/NIR-II Fluorescence Imaging of Breast Cancer Bone Metastases

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 268, P. 116903 - 116903

Published: Nov. 1, 2024

Language: Английский

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