International Journal of Biological Sciences,
Journal Year:
2024,
Volume and Issue:
20(14), P. 5747 - 5763
Published: Oct. 21, 2024
Bone
metastasis
is
a
common
cause
of
death
in
patients
with
non-small
cell
lung
cancer
(NSCLC),
approximately
30-40%
NSCLC
eventually
developing
bone
metastases.
metastasis,
especially
the
occurrence
skeletal-related
events
(SREs),
significantly
reduces
overall
survival
(OS)
and
quality
life
(QoL)
patients.
Although
bone-targeting
agents
(BTAs)
have
been
shown
to
reduce
SREs
improve
QoL
metastases,
prognosis
for
these
remains
poor.
Understanding
underlying
molecular
pathways
crucial
development
novel
therapeutic
approaches.
complex,
multistep
process
that
involves
interactions
between
tumor
cells
microenvironment.
The
microenvironment
provides
fertile
soil
cells,
crosstalk
among
various
signaling
secreted
factors
also
plays
role
regulating
progression
NSCLC.
In
this
article,
we
provide
comprehensive
review
process,
regulatory
mechanisms,
clinical
treatment
hope
assisting
treatment.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6723 - 6723
Published: June 18, 2024
Arsenic
compounds
have
been
used
as
therapeutic
alternatives
for
several
diseases
including
cancer.
In
the
following
work,
we
obtained
arsenic
nanoparticles
(AsNPs)
produced
by
an
anaerobic
bacterium
from
Salar
de
Ascotán,
in
northern
Chile,
and
evaluated
their
effects
on
human
oral
squamous
carcinoma
cell
line
OECM-1.
Resazurin
reduction
assays
were
carried
out
these
cells
using
1–100
µM
of
AsNPs,
finding
a
concentration-dependent
viability
that
was
not
observed
non-tumoral
gastric
mucosa-derived
GES-1.
To
establish
if
associated
with
apoptosis
induction,
markers
like
Bcl2,
Bax,
cleaved
caspase
3
analyzed
via
Western
blot,
executor
caspases
3/7
luminometry,
DNA
fragmentation
TUNEL
assay,
100
cisplatin
positive
control.
OECM-1
treated
AsNPs
showed
induction
both
extrinsic
intrinsic
apoptotic
pathways,
which
can
be
explained
significant
decrease
P-Akt/Akt
P-ERK/ERK
relative
protein
ratios,
increase
PTEN
p53
mRNA
levels
Bit-1
levels.
These
results
suggest
prospective
mechanism
action
involves
potential
interaction
extracellular
matrix
(ECM)
components
reduces
attachment
subsequently
triggers
anoikis,
anchorage-dependent
type
apoptosis.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
19(5), P. 100949 - 100949
Published: Aug. 23, 2024
Tumor
metastasis
is
responsible
for
90%
of
cancer-associated
deaths,
and
its
early
detection
may
decrease
the
likelihood
mortality.
Studies
have
demonstrated
that
results
from
interaction
between
"seeds"
(tumor
cells)
"soil"
(pre-metastatic
niche,
PMN).
As
first
most
abundant
immune
cells
to
be
recruited
PMN,
neutrophils
play
a
key
role
in
ultimate
formation
metastatic
foci
through
mechanisms
such
as
supporting
tumor
cell
growth,
promoting
angiogenesis,
shaping
an
immune-suppressive
microenvironment.
In
this
study,
two
distinct
types
sialic
acid
(SA)-modified
liposomes
were
prepared
target
regulate
pro-metastatic
l-selectin
receptor.
One
these
liposomes,
named
ICG@SAL,
was
used
encapsulate
indocyanine
green
(ICG)
specifically
designed
cancer
metastasis.
The
other
liposome,
referred
ABE/Cur@SAL,
co-loaded
abemaciclib
(ABE)
curcumin
(Cur),
with
intention
suppressing
progression
tumor.
Fluorescence
imaging
mouse
spontaneous
model
indicated
ICG@SAL
faster
targeting
stronger
accumulation
organs
than
unmodified
ICG
(ICG@CL).
This
suggested
could
detect
at
stage.
therapy
experimental
lung
ABE/Cur@SAL
inhibit
regulatory
T
(Treg)
proliferation,
enhance
effector
activity
reduce
tumorigenic
factor
release,
implying
Overall,
our
work
provided
sensitive
convenient
approach
diagnosis
treatment
employed
metastasis,
while
development
when
identified.
International Journal of Biological Sciences,
Journal Year:
2024,
Volume and Issue:
20(14), P. 5747 - 5763
Published: Oct. 21, 2024
Bone
metastasis
is
a
common
cause
of
death
in
patients
with
non-small
cell
lung
cancer
(NSCLC),
approximately
30-40%
NSCLC
eventually
developing
bone
metastases.
metastasis,
especially
the
occurrence
skeletal-related
events
(SREs),
significantly
reduces
overall
survival
(OS)
and
quality
life
(QoL)
patients.
Although
bone-targeting
agents
(BTAs)
have
been
shown
to
reduce
SREs
improve
QoL
metastases,
prognosis
for
these
remains
poor.
Understanding
underlying
molecular
pathways
crucial
development
novel
therapeutic
approaches.
complex,
multistep
process
that
involves
interactions
between
tumor
cells
microenvironment.
The
microenvironment
provides
fertile
soil
cells,
crosstalk
among
various
signaling
secreted
factors
also
plays
role
regulating
progression
NSCLC.
In
this
article,
we
provide
comprehensive
review
process,
regulatory
mechanisms,
clinical
treatment
hope
assisting
treatment.
