Ultrasound -Induced Thermal Effect Enhances the Efficacy of Chemotherapy and Immunotherapy in Tumor Treatment DOI Creative Commons

Yuting Xiang,

Li Tang,

Hua Pang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 6677 - 6692

Published: July 1, 2024

The inadequate perfusion, frequently resulting from abnormal vascular configuration, gives rise to tumor hypoxia. presence of this condition hinders the effective delivery therapeutic drugs and infiltration immune cells into tumor, thereby compromising efficacy treatments against tumors. objective study is exploit thermal effect ultrasound (US) in order induce localized temperature elevation within facilitating vasodilation, augmenting drug delivery, enhancing cell infiltration.

Language: Английский

Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications DOI Creative Commons
Priyanka Singh, Santosh Pandit, Sri Renukadevi Balusamy

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)

Published: Nov. 6, 2024

Cancer remains one of the most challenging health issues globally, demanding innovative therapeutic approaches for effective treatment. Nanoparticles, particularly those composed gold, silver, and iron oxide, have emerged as promising candidates changing cancer therapy. This comprehensive review demonstrates landscape nanoparticle-based oncological interventions, focusing on remarkable advancements potentials oxide nanoparticles. Gold nanoparticles garnered significant attention their exceptional biocompatibility, tunable surface chemistry, distinctive optical properties, rendering them ideal various diagnostic strategies. Silver nanoparticles, renowned antimicrobial exhibit potential in therapy through multiple mechanisms, including apoptosis induction, angiogenesis inhibition, drug delivery enhancement. With magnetic properties offer unique diagnosis targeted opportunities. critically examines recent synthesis, functionalization, biomedical applications these Moreover, challenges are discussed, toxicity concerns, immunogenicity, translational barriers, ongoing efforts to overcome hurdles highlighted. Finally, insights into future directions regulatory considerations, provided aiming accelerate translation technologies from bench bedside.

Language: Английский

Citations

7
Circulating microRNAs: A remarkable opportunity as non-invasive biomarkers from adult to pediatric brain tumor patients DOI
Federica D’Antonio, Zaira Spinello,

Lavinia Bargiacchi

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104650 - 104650

Published: Feb. 1, 2025

Language: Английский

Citations

0
Ultrasound-responsive nanoparticles for imaging and therapy of brain tumors DOI Creative Commons
Zhiguang Chen, Liang Sang,

Zhai Qixi

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101661 - 101661

Published: March 1, 2025

Language: Английский

Citations

0
Lipid nanoparticles for treatment of glioblastoma multiforme: current status of research and clinical translation DOI Creative Commons
Mugdha Kulkarni, Karthik Nadendla, Ananth Pai

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106891 - 106891

Published: April 1, 2025

Language: Английский

Citations

0
Nanomaterials for promoting axon regeneration after spinal cord injury: Mechanisms and prospects DOI Creative Commons
Jia Liu, Zhen-Dong Huang,

Xiner Tan

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 20, 2025

Abstract The establishment of new functional connections through axon regeneration is essential for recovery following spinal cord injury (SCI). With the rapid advancement nanotechnology, nanomaterial (NM)‐based therapies have emerged as promising approaches to promote after SCI. Specifically, NMs can limit spread damage, maintain homeostasis in extracellular environment surrounding injured axons, and ultimately facilitate growth In particular, with enzyme‐like properties, such cerium oxide manganese dioxide, clear reactive oxygen species damaged area, thereby promoting regeneration. Additionally, electromagnetic properties guide under influence magnetic or electric fields. Importantly, biological mechanisms by which are summarized discussed explore NM‐based strategies achieving Together, elucidating physicochemical basis their promotion SCI help fill gaps our understanding how be used treat further clinical translation future.

Language: Английский

Citations

0
Advances in magnetic field approaches for non-invasive targeting neuromodulation DOI Creative Commons
Mozhgan Alipour,

Maryam Abdolmaleki,

Yaser Shabanpour

et al.

Frontiers in Human Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 28, 2025

Neuromodulation, the targeted regulation of nerve activity, has emerged as a promising approach for treating various neurological and psychiatric disorders. While deep brain stimulation shown efficacy, its invasive nature poses substantial risks, including surgical complications high costs. In contrast, non-invasive neuromodulation techniques, particularly those utilizing magnetic fields (MFs), have gained increasing attention safer, more accessible alternatives. Magnetothermal an innovative method that enables precise modulation neuronal ion channels through localized heating induced by interaction MF with biological tissues. This review discusses principles MF-based highlights critical role in synaptic transmission, therapeutic potential these advanced techniques. Additionally, it key challenges such spatial targeting precision, safety considerations, long-term effects exposure on function. The findings presente promise non-invasive, highly strategy conditions epilepsy, movement disorders, neurodegenerative diseases, applications chronic pain management future clinical interventions.

Language: Английский

Citations

0
Nanomedicine for cancer patient‐centered care DOI Creative Commons
Carlo Sorrentino, Stefania L. Ciummo, Cristiano Fieni

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(11)

Published: Oct. 20, 2024

Abstract Cancer is a leading cause of morbidity and mortality worldwide, an increase in incidence estimated the next future, due to population aging, which requires development highly tolerable low‐toxicity cancer treatment strategies. The use nanotechnology tailor treatments according genetic immunophenotypic characteristics patient's tumor, allow its targeted release, can meet this need, improving efficacy minimizing side effects. Nanomedicine‐based approach for diagnosis rapidly evolving field. Several nanoformulations are currently clinical trials, some have been approved marketed. However, their large‐scale production still hindered by in‐depth debate involving ethics, intellectual property, safety health concerns, technical issues, costs. Here, we survey key approaches, with specific reference organ‐on chip technology, cutting‐edge tools, such as CRISPR/Cas9 genome editing, through nanosystems needs personalized diagnostics therapy patients. An update provided on nanopharmaceuticals marketed those undergoing trials. Finally, discuss emerging avenues field challenges be overcome transfer nano‐based precision oncology into daily life.

Language: Английский

Citations

2
The anti-glypican 1 AT101 antibody as targeting agent to effectively deliver chitosan nanobubbles to glioblastoma cells DOI
Federica Di Cintio, Monica Argenziano, Anna Scomparin

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Dec. 2, 2024

Background Recently, we developed AT101, an IgM-class mouse monoclonal antibody directed against glypican-1 (GPC1), a proteoglycan that can be considered as useful target for glioblastoma multiforme (GBM) treatment being specifically and highly expressed on GBM cell surface. Here, proposed the use of AT101 targeting agent in drug delivery nanoplatfom to effectively deliver chitosan nanobubbles (NBs) treatment.

Language: Английский

Citations

2
Ultrasound -Induced Thermal Effect Enhances the Efficacy of Chemotherapy and Immunotherapy in Tumor Treatment DOI Creative Commons

Yuting Xiang,

Li Tang,

Hua Pang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 6677 - 6692

Published: July 1, 2024

The inadequate perfusion, frequently resulting from abnormal vascular configuration, gives rise to tumor hypoxia. presence of this condition hinders the effective delivery therapeutic drugs and infiltration immune cells into tumor, thereby compromising efficacy treatments against tumors. objective study is exploit thermal effect ultrasound (US) in order induce localized temperature elevation within facilitating vasodilation, augmenting drug delivery, enhancing cell infiltration.

Language: Английский

Citations

1