Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 23, 2025
Interest
in
prostate
cancer
as
a
research
topic
has
gradually
increased.
As
result,
series
of
innovative
treatment
strategies
have
emerged
with
an
in-depth
understanding
the
disease.
Owing
to
their
unique
biological
characteristics,
mesenchymal
stromal
cell
exosomes
(MSC-Exos)
garnered
significant
attention
for
potential
deliver
targeted
drugs
and
enable
precise
treatment.
Herein,
MSC-Exos
drug-delivery
systems
is
reviewed.
This
review
provides
comprehensive
introduction
advantages
these
systems,
current
trends
progress,
well
analysis
challenges
future
directions.
Moreover,
this
lays
solid
foundation
continued
development
application
MSC-Exos.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 5, 2024
Abstract
Diabetic
wounds
are
characterized
by
incomplete
healing
and
delayed
healing,
resulting
in
a
considerable
global
health
care
burden.
Exosomes
lipid
bilayer
structures
secreted
nearly
all
cells
express
characteristic
conserved
proteins
parent
cell-associated
proteins.
harbor
diverse
range
of
biologically
active
macromolecules
small
molecules
that
can
act
as
messengers
between
different
cells,
triggering
functional
changes
recipient
thus
endowing
the
ability
to
cure
various
diseases,
including
diabetic
wounds.
accelerate
wound
regulating
cellular
function,
inhibiting
oxidative
stress
damage,
suppressing
inflammatory
response,
promoting
vascular
regeneration,
accelerating
epithelial
facilitating
collagen
remodeling,
reducing
scarring.
from
tissues
or
potentially
possess
functions
varying
levels
promote
healing.
For
example,
mesenchymal
stem
cell-derived
exosomes
(MSC-exos)
have
favorable
potential
field
due
their
superior
stability,
permeability,
biocompatibility,
immunomodulatory
properties.
Exosomes,
which
derived
skin
components,
modulate
inflammation
regeneration
key
turn
promotes
Therefore,
this
review
mainly
emphasizes
roles
mechanisms
sources,
represented
MSCs
improving
A
deeper
understanding
therapeutic
will
yield
promising
candidates
perspectives
for
management.
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(2), P. 965 - 989
Published: Jan. 23, 2024
Nerve
growth
factor
(NGF)
plays
a
dual
role
both
in
inflammatory
states
and
cancer,
acting
as
pro-inflammatory
oncogenic
an
anti-inflammatory
pro-apoptotic
mediator
context-dependent
way
based
on
the
signaling
networks
its
interaction
with
diverse
cellular
components
within
microenvironment.
This
report
aims
to
provide
summary
subsequent
review
of
literature
NGF
regulating
microenvironment
tumor
cell
growth,
survival,
death.
The
inflammation
tumorigenesis
component
system,
various
respective
microenvironments,
ability
cause
epigenetic
changes,
treatment
cancer
have
been
highlighted
this
paper.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 13, 2025
This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
Clinical and Translational Medicine,
Journal Year:
2024,
Volume and Issue:
14(4)
Published: April 1, 2024
Breast
cancer
remains
a
global
health
challenge,
necessitating
innovative
therapeutic
approaches.
Immunomodulation
and
immunotherapy
have
emerged
as
promising
strategies
for
breast
treatment.
Engineered
exosomes
are
the
sort
of
modified
with
surface
decoration
internal
molecules.
Through
suitable
modifications,
engineered
exhibit
capability
to
overcome
limitations
associated
traditional
This
ability
opens
up
novel
avenues
development
more
effective,
personalized,
minimally
invasive
interventions.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
179, P. 117296 - 117296
Published: Aug. 20, 2024
Over
the
past
decades,
cancer
immunotherapy
has
encountered
challenges
such
as
immunogenicity,
inefficiency,
and
cytotoxicity.
Consequently,
exosome-based
gained
rapid
traction
a
promising
alternative.
Exosomes,
type
of
extracellular
vesicles
(EVs)
ranging
from
50
to
150
nm,
are
self-originating
exhibit
fewer
side
effects
compared
traditional
therapies.
Exosome-based
encompasses
three
significant
areas:
vaccination,
co-inhibitory
checkpoints,
adoptive
T-cell
therapy.
Each
these
fields
leverages
inherent
advantages
exosomes,
demonstrating
substantial
potential
for
individualized
tumor
therapy
precision
medicine.
This
review
aims
elucidate
reasons
behind
promise
nanoparticles
therapies
by
examining
their
characteristics
summarizing
latest
research
advancements
in
immunotherapy.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101469 - 101469
Published: Jan. 9, 2025
Premature
ovarian
insufficiency
(POI)
refers
to
the
severe
decline
or
failure
of
function
in
women
younger
than
40
years
age.
It
is
a
serious
hazard
women's
physical
and
mental
health,
but
current
treatment
options
are
limited.
Mesenchymal
stem
cell-derived
exosomes
(MSC-Exo)
exhibit
promising
potential
as
therapeutic
approach
for
POI.
However,
their
clinical
application
hindered
by
instability
low
long-term
retention
rate
vivo.
In
this
study,
miR-21
was
identified
predominant
miRNA
with
low-expression
follicular
fluid
POI
patients
shown
possess
antiapoptotic
activity.
Next,
we
loaded
agomir
MSC-Exo
form
Agomir21-Exo,
which
significantly
reversed
apoptosis
granulosa
cells
vitro.
Moreover,
successfully
developed
GelMA
hydrogel
microspheres
encapsulating
Agomir21-Exo
through
microfluidic
technology,
named
GelMA-Ag21Exo,
had
good
injectability
enhanced
stability
mice
sustained
release.
The
release
from
GelMA-Ag21Exo
notably
alleviated
improved
reserve
fertility
mice.
Our
findings
illustrate
that
activating
could
improve
cells.
exosome-based
efficacy
These
provide
novel
strategy
patients.
World Journal of Gastrointestinal Oncology,
Journal Year:
2025,
Volume and Issue:
17(3)
Published: Feb. 13, 2025
In
this
article,
we
revisit
an
which
specifically
focuses
on
the
utilization
of
exosomes
derived
from
human
bone
marrow
mesenchymal
stem
cells
(MSCs)
for
targeted
delivery
gemcitabine
in
pancreatic
cancer
treatment.
The
experimental
results
demonstrated
that
exosome-based
drug
system
MSCs
significantly
augmented
apoptosis
cells.
biocompatibility,
targeting
specificity,
and
low
immunogenicity
render
them
as
optimal
carriers
delivery,
enabling
precise
administration
therapeutics
to
diseased
tissues
while
mitigating
adverse
effects,
thereby
achieving
treatment
enhancing
anti-tumor
efficacy.
However,
clinical
application
exosome
platforms
oncology
still
presents
challenges,
necessitating
further
optimization
ensure
their
stability
This
study
elucidating
advantages
a
platform,
exploring
MSC-derived
therapy,
discussing
potential
future
directions
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 3175 - 3199
Published: March 1, 2025
Extracellular
vesicles
(EVs)
participate
in
intercellular
communication
and
play
an
essential
role
physiological
pathological
processes.
In
recent
years,
EVs
have
garnered
significant
attention
as
cell-free
therapeutic
alternatives,
vectors
for
drug
gene
delivery,
biomarkers
disease
diagnosis
prognosis,
vaccine
development,
nutraceuticals.
The
biodistribution
of
critically
influences
their
efficacy
toxicity.
Therefore,
this
review
aims
to
discuss
the
main
factors
influencing
unmodified
EVs,
highlighting
distribution
patterns,
advantages,
limitations,
applications
under
different
routes
administration.
addition,
we
provide
a
comprehensive
discussion
currently
available
sources
summarize
current
status
potentials
EVs.
By
optimizing
administration
selecting
appropriate
EV
sources,
aim
offer
valuable
insights
enhance
delivery
efficiency
target
tissues.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5955 - 5955
Published: May 29, 2024
Bladder
cancer
(BC)
is
a
common
genitourinary
malignancy
that
exhibits
silent
morbidity
and
high
mortality
rates
because
of
lack
diagnostic
markers
limited
effective
treatments.
Here,
we
evaluated
the
role
lncRNA
brain
cytoplasmic
RNA
1
(BCYRN1)
in
BC.
We
performed
loss-of-function
assays
to
examine
effects
BCYRN1
downregulation
T24
BOY
BC
cells.
found
significantly
inhibited
proliferation,
migration,
invasion,
three-dimensional
spheroid
formation
ability
induced
apoptosis
Additionally,
gene
set
enrichment
analysis
(GSEA)
using
sequences
from
tumor
fractions
showed
decreased
expression
mRNAs
associated
with
cell
cycle.
These
findings
were
supported
by
observations
G2/M
arrest
flow
cytometry
assays.
Finally,
examined
serum
exosomal
as
biomarker.
Clinically,
exosomes
patients
(n
=
31)
was
higher
than
healthy
donors
19;
mean
difference:
4.1-fold
higher,
p
<
0.01).
Moreover,
who
had
undergone
complete
resection
BC,
levels
8).
Thus,
may
be
promising
marker
therapeutic
target
