A Graphene-Based Lipid Modulation Nanoplatform for Synergetic Lipid Starvation/Chemo/Photothermal Therapy of Oral Squamous Cell Carcinoma DOI Creative Commons
Ran Li, Yanwei Li,

Zijian Song

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 11235 - 11255

Published: Nov. 1, 2024

Purpose: Chemotherapy is one of the most commonly used treatments for oral squamous cell carcinoma (OSCC), but its use limited by drug resistance and severe systemic toxicity. To eliminate these side effects improve anti-tumor efficacy, several therapeutic approaches have been developed with chemotherapy. In this study, we a graphene-based lipid modulation nanoplatform (NSD) that carries SB-204990, small molecule inhibitor specific ATP citrate lyase (ACLY), doxorubicin (DOX), chemotherapeutic agent, trio enables synergistic treatment OSCC starvation, chemotherapy, photothermal therapy. Methods: We first determined whether ACLY expression was upregulated in OSCC, then assessed growth inhibitory SB-204990 on SCC-15 cells changes (acetyl coenzyme A, free fatty acids, cholesterol) levels. characterized NSD evaluated stability, properties, loading, release ability NSD. Finally, were investigated vitro vivo experiments, levels tissues after inhibition further evaluated. Results: The results showed highly expressed produced reproductive suppression decreased cells. possessed good high loading capacity controlled release. addition, triple therapy achieved satisfactory anticancer both assays, rate tumors as 99.4% NSD+Laser group. Conclusion: tumor proliferation arrest induced suggest may be promising target starvation to chemoresistance, inhibitors are expected become new drugs. nanocarrier system therapy, which represents an innovative approach combating tumors. Keywords: ACLY, nanotechnology, chemotherapy resistance,

Language: Английский

Innovations in Functional Materials and Advanced Imaging Techniques for Targeting Extramural Venous Invasion (EMVI) in Colorectal Cancer: A Comprehensive Review DOI

Noura A. A. Ebrahim,

Soliman M. A. Soliman

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

1
Graphene-Metal Nanocrystal Hybrid Materials for Bioapplications DOI
Xiaoxu Cao, Shengkai Li, Shen Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(39), P. 51816 - 51825

Published: Sept. 24, 2024

The development of functional nanomaterials is crucial for advancing personalized and precision medicine. Graphene-metal nanocrystal hybrid materials not only possess the intrinsic advantages graphene-based but also exhibit additional optical, magnetic, catalytic properties various metal nanocrystals, showing great synergies in bioapplications, including biosensing, bioimaging, disease treatments. In this Perspective, we discuss design principles graphene-metal provide an overview their applications biological fields. Finally, highlight challenges future directions practical implementation.

Language: Английский

Citations

2
A Graphene-Based Lipid Modulation Nanoplatform for Synergetic Lipid Starvation/Chemo/Photothermal Therapy of Oral Squamous Cell Carcinoma DOI Creative Commons
Ran Li, Yanwei Li,

Zijian Song

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 11235 - 11255

Published: Nov. 1, 2024

Purpose: Chemotherapy is one of the most commonly used treatments for oral squamous cell carcinoma (OSCC), but its use limited by drug resistance and severe systemic toxicity. To eliminate these side effects improve anti-tumor efficacy, several therapeutic approaches have been developed with chemotherapy. In this study, we a graphene-based lipid modulation nanoplatform (NSD) that carries SB-204990, small molecule inhibitor specific ATP citrate lyase (ACLY), doxorubicin (DOX), chemotherapeutic agent, trio enables synergistic treatment OSCC starvation, chemotherapy, photothermal therapy. Methods: We first determined whether ACLY expression was upregulated in OSCC, then assessed growth inhibitory SB-204990 on SCC-15 cells changes (acetyl coenzyme A, free fatty acids, cholesterol) levels. characterized NSD evaluated stability, properties, loading, release ability NSD. Finally, were investigated vitro vivo experiments, levels tissues after inhibition further evaluated. Results: The results showed highly expressed produced reproductive suppression decreased cells. possessed good high loading capacity controlled release. addition, triple therapy achieved satisfactory anticancer both assays, rate tumors as 99.4% NSD+Laser group. Conclusion: tumor proliferation arrest induced suggest may be promising target starvation to chemoresistance, inhibitors are expected become new drugs. nanocarrier system therapy, which represents an innovative approach combating tumors. Keywords: ACLY, nanotechnology, chemotherapy resistance,

Language: Английский

Citations

0