How Will Nanomedicine Revolutionize Future Dentistry and Periodontal Therapy?

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 592 - 592

Published: Jan. 12, 2025

Periodontitis is a prevalent inflammatory disease affecting the supporting structures of teeth, leading to gum recession, tooth loss, and systemic health complications. Traditional diagnostic methods treatments, such as clinical evaluation scaling, often fall short in early detection targeted therapy, particularly complex or advanced cases. Recent advancements nanomedicine offer promising solutions for improving both diagnosis treatment periodontitis. Nanoparticles, liposomes, quantum dots, nanorods, have demonstrated potential enhancing accuracy by enabling more precise periodontal pathogens biomarkers at molecular level. Furthermore, nanotechnology-based therapies, including drug delivery systems antimicrobial agents, localized controlled release therapeutic efficacy reducing side effects compared conventional treatments. This study reviews current applications periodontitis, highlighting its revolutionize care detection, times, outcomes.

Language: Английский

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Fe₃O₄-Based Nanospheres with High Photothermal Conversion Efficiency for Dual-Effect and Mild Biofilm Eradication against Periodontitis

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Periodontitis, a chronic inflammatory oral disease resulting from plaque biofilms, affects about 743 million individuals worldwide. However, the efficacy of current treatments is hampered by challenges in delivering antibiotics to recalcitrant biofilms and bacterial resistance, thereby impeding successful treatment infectious diseases. To address issues, an antibacterial photothermal material was designed, comprising spherical structure zinc oxide (ZnO) wrapped with triiron tetraoxide (Fe3O4). The outer layer adsorbed epsilon-polylysine (EPL) electrostatic action, ultimately leading fabrication Fe3O4/ZnO/EPL nanoparticles (FZE NPs). Fe3O4 core endowed efficient properties, facilitating dispersion dense which dramatically promoted adsorption penetration ZnO EPL into effectively kill bacteria vitro enhanced sterilization ability. Additionally, upon dissolution aqueous media, acts as positively charged antimicrobial peptide that adsorbs onto surface negatively membranes, modulating responses. In order ascertain FZE NPs, investigation conducted their effects against periodontitis-associated pathogen Porphyromonas gingivalis (P. gingivalis) vitro. Furthermore, antiperiodontitis potential NPs evaluated Sprague-Dawley (SD) rats ligamentous periodontitis. addition, toxicity evaluations indicated had acceptable biosafety profile vivo. summary, nanospheres NPs) represent promising therapeutic strategy for

Language: Английский

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Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes Attenuates Experimental Periodontitis in Mice Partly by Delivering miRNAs

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2879 - 2899

Published: March 1, 2025

Introduction: Periodontitis is the most common non-communicable disease in humans. The main challenge treatment of periodontitis to effectively control periodontal inflammation and promote tissue repair. Human umbilical cord mesenchymal stem cells-derived exosomes (hucMSCs-exo) have been reported modulate inflammatory responses repairment mainly through miRNAs several diseases. However, effect hucMSCs-exo on remains unknown. In this study, we hypothesized that could inhibit bone destruction mice. Methods: constructed characterized exo@H drug delivery platform. Lipopolysaccharide was used construct an microenvironment vitro detect MC3T3-E1 cells proliferation regeneration capacity. Ligation induced experimental mouse model. distance cement-enamel junction (CEJ) alveolar crest (ABC) measured for resorption evaluation. Hematoxylin-eosin (H&E) staining Tartrate resistant acid phosphatase (TRAP) were observe changes. MicroRNA (miRNA) sequencing differential genes bioinformatics analysis. Real-time quantitative polymerase chain reaction (qRT-PCR). WB assay dual luciferase further validate screened differentially expressed targeted binding relationship with corresponding target genes. Results: We found lyophilized promoted osteogenic differentiation cells, showed more significant proliferative abilities combination hydrogel ( P < 0.05). Using mice, evaluation revealed a reduction group compared 0.01), able reduce response tissues number osteoclasts surface group. Moreover, 59 upregulated, such as let-7f-5p miR-203-3p, which positively IL-13 Nit2, respectively. Discussion: These results suggest provides protection against partly by delivering tissue. Our confirm feasibility platform effectiveness its use treatment, study promising approach via miRNA. Keywords: periodontitis, exosomes, MC3T3-E1, microRNA, gene

Language: Английский

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Design and application of antimicrobial nanomaterials in the treatment of periodontitis

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: March 5, 2025

Periodontitis is a chronic inflammatory disease induced by the microbiome, leading to destruction of periodontal structures and potentially resulting in tooth loss. Using local drug delivery systems as an adjunctive therapy scaling root planning periodontitis promising strategy. However, this administration method's effectiveness constrained complexity environment. Nanomaterials have demonstrated significant potential antibacterial treatment periodontitis, attributed their controllable size, shape, surface charge, high design flexibility, reactivity, specific area. In review, we summarize complex microenvironment difficulties explicitly reviewing application strategies nanomaterials with unique properties distinct periodontitis. Furthermore, review discusses limitations current research, proposes feasible solutions, explores prospects for using context.

Language: Английский

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A Narrative Review of Periodontal Vaccines: Hope or Hype?

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Globally, periodontal diseases, mainly driven by polymicrobial biofilms, are a widespread concern of social medicine due to their considerable incidence and tie-up systemic disorders like diabetes, cardiovascular complications during pregnancy. Traditional treatments focus on mechanical debridement antimicrobial therapies, but these approaches have limitations, including recurrence antibiotic resistance. Periodontal vaccines offer promising alternative targeting the immunological mechanisms underlying disease. This review explores current state vaccine development, highlighting key antigens, delivery systems, preclinical clinical advancements. Special emphasis is placed antigen selection, host variability, immune tolerance, future directions overcome barriers. article highlights advancements challenges in research, offering insights into capability immunoprophylaxis as groundbreaking way manage diseases.

Language: Английский

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Nanoparticles as Strategies for Modulating the Host’s Response in Periodontitis Treatment

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(7), P. 476 - 476

Published: March 21, 2025

Periodontitis is a widespread disease, associated with challenges both in its diagnosis and selecting from various therapeutic approaches, which do not always yield the expected success. This literature review was conducted to explore diverse especially those focused on nanotechnologies, their potential contribution successful modulation of host’s response. The effects existing microbial diversity imbalance key species contributing progression worsening response periodontitis are well known. It essential understand role well-structured treatment plan for periodontitis, providing opportunities new research innovative strategies aimed at reducing impact oral overall systemic health. will be beneficial dental professionals, enabling them effectively prevent treat ultimately improving health well-being patients.

Language: Английский

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Comparative Evaluation of Cytotoxicity, Anti-inflammatory, and Drug Release Profiles of Allicin-incorporated GO-AgNP Hydrogel: An In Vitro Study

The Journal of Contemporary Dental Practice, Journal Year: 2025, Volume and Issue: 26(1), P. 71 - 76

Published: March 28, 2025

This study evaluates the cytotoxicity, anti-inflammatory effects, and drug release profiles of an allicin-incorporated graphene oxide-silver nanoparticle (GO-AgNP) hydrogel as intracanal medicament. The GO-AgNP was synthesized characterized using transmission electron microscopy. Human periodontal ligament (PDL) fibroblasts were used for 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cytotoxicity assays, assessing cell viability at 10, 25, 50, 100 µg/mL concentrations over 24, 48, 72 hours. Anti-inflammatory effects evaluated by analyzing interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α expression in lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells via quantitative polymerase chain reaction 24 hours 7 days. Drug assessed ultraviolet-visible spectrophotometry 168 root canal-treated teeth. exhibited concentration-dependent with exceeding 90% 10-20 but decreasing significantly 50-100 (p < 0.05). half-maximal inhibitory concentration approximately 45 µg/mL. assays showed a reduction IL-6 (45%), IL-8 (38%), TNF-α (42%) compared LPS-treated control analysis revealed sustained pattern, 20 demonstrating higher cumulative than 10 hydrogel. demonstrates potential biocompatible medicament properties controlled release. Further optimization is required clinical application. shows promise due to its biocompatibility, properties, By modulating inflammatory response, it may contribute reduced postoperative discomfort improved periapical healing. Additionally, bioactive support tissue repair regeneration, making candidate regenerative endodontic procedures. How cite this article: Piriyanga R, Ranjan M, Bathla S, et al. Comparative Evaluation Cytotoxicity, Anti-inflammatory, Release Profiles Allicin-incorporated Hydrogel: An In Vitro Study. J Contemp Dent Pract 2025;26(1):71-76.

Language: Английский

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Nanotechnology-Driven Drug Delivery in Rheumatoid Arthritis: Current Trends, Key Challenges, and Future Perspectives

Biosciences Biotechnology Research Asia, Journal Year: 2025, Volume and Issue: 22(1), P. 1 - 21

Published: March 25, 2025

ABSTRACT: Rheumatoid arthritis is a chronic autoimmune disorder that causes progressive joint damage and disability, significantly impacting patients' quality of life. In this Traditional treatment, including disease-modifying ant rheumatic drugs biologics often fall short in targeting the disease with precision, leading to side effects limited efficacy. We selected Nanotechnology which offers promising solution for improving drug delivery enhancing therapeutic outcomes RA management. This review explores current trends future prospects nanotechnology-based systems treatment. discuss various types nanocarriers, such as nanoparticles, liposomes, micelles, their ability enhance targeted biologic agents small molecules. Additionally, we examine potential "smart" nanomaterials respond disease-specific stimuli controlled release, thereby reducing systemic toxicity. The integration nanotechnology biologics, gene therapies, combination treatments highlighted strategy efficacy minimizing adverse effects. Finally, addresses ongoing challenges directions, need more extensive clinical trials ensure safety effectiveness these innovative therapies patients.

Language: Английский

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Engineered Macrophage Membrane-Camouflaged Nanodecoys Reshape the Infectious Microenvironment for Efficient Periodontitis Treatment

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

A vicious cycle between microbiota dysbiosis and hyperactivated inflammation, hardly disrupted by conventional therapies, remains a significant clinical challenge for periodontitis treatment. Herein, cloaking cascade catalysis system in an engineered macrophage membrane, nanodecoy-based strategy, with targeted bacteria-killing immunomodulatory abilities, is proposed reshaping the hostile microenvironment. Specifically, recombinant human antimicrobial peptide, LL-37, anchored to Toll-like receptor-enriched membrane via genetic engineering, which facilitates specific bacteria elimination efficient tissue retention of nanodecoys. Moreover, integrates L-amino acid oxidase (LAAO) hollowed manganese dioxide (hMnO2) reciprocal elevation catalytic efficiency hMnO2 LAAO, leading accelerated O2 generation under hypoxic microenvironment metabolism periodontopathogenic bacteria. Notably, nanodecoys trigger nuclear translocation NF-E2-related factor-2 (NRF2) reduce oxidative stress response rewire polarization macrophages, thereby boosting osteogenic differentiation osteoblasts. Furthermore, alveolar bone regeneration therapeutically benefits from vivo. Altogether, these results highlight attractive functions membrane-cloaked effective

Language: Английский

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Nanorough Surface of Fibronectin Grafted Bioactive Zirconia Dental Implants by Using Glow Discharge Plasma Promotes Osseointegration in a Rabbit Model

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12615 - 12631

Published: Nov. 1, 2024

Nano-engineering techniques have significantly enhanced the various aspects of dentistry, with notable advancements, especially in dental implant surface modification. Dental implants are among most significant and highly successful developments contemporary dentistry. The use nanotechnology for modification zirconia ceramic increases interaction surrounding bone cells, ultimately leading to increase osseointegration.

Language: Английский

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