Application of liposomal nanoparticles of berberine in photodynamic therapy of A549 lung cancer spheroids DOI Creative Commons
Kave Moloudi, Heidi Abrahamse, Blassan P. George

et al.

Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 40, P. 101877 - 101877

Published: Nov. 17, 2024

Language: Английский

From natural herbal wisdom to nano innovation: Revolutionizing tumor treatment through metabolic reprogramming DOI
Zhengguang Zhang, Haitao Wu, Min Li

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189263 - 189263

Published: Jan. 1, 2025

Language: Английский

Citations

0
Berberine disrupts the high-affinity iron transport system to reverse the fluconazole-resistance in Candida albicans DOI

Daifan Yue,

Dongming Zheng,

Linlan Yang

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107370 - 107370

Published: Feb. 1, 2025

Language: Английский

Citations

0
From Nature to Nanotech: Unlocking Berberine’s Therapeutic Approaches DOI

Shubham Chaudhari,

Manoj Dalabehera,

Rudra Narayan Subudhi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106924 - 106924

Published: April 1, 2025

Language: Английский

Citations

0
In Vitro Evaluation of the Safety and Antineoplastic Effects in Gastrointestinal Tumors of Nanostructured Lipid Carriers Loaded with Berberine DOI Creative Commons
Denitsa Stefanova, Yordan Yordanov,

Radostina Bogdanova

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 331 - 331

Published: March 4, 2025

Background/Objectives: Natural substances have been a widely studied source of both pharmaceutical excipients and drugs. Berberine (BRB) is benzylisoquinoline alkaloid isolated from different plant sources. It possesses various pharmacological properties including antibacterial, antitumor, antidiabetic, neuroprotective, hepatoprotective, anti-inflammatory, antioxidant, etc. However, the limited aqueous solubility hinders its application. Nanosized drug delivery systems are an innovative approach for addressing challenges regarding via routes administration. Their utilization could improve active constituents. Methods: A melt-emulsification ultrasonication technique was applied preparation nanostructured lipid carriers (NLCs). They were thoroughly physicochemically characterized by means Dynamic Light Scattering, TEM, FTIR, DSC, TGA, In Vitro release. The efficacy safety evaluated on cholangiocarcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, lymphoma, fibroblast, cardioblast cells, as well rat liver microsomes cytotoxicity assays comet assay. Results: obtained nanoparticles had spherical shape size around 158.2 ± 1.8 nm with negative zeta potential. revealed successful loading improved dissolution berberine in physiological conditions. studies showed that BRB NLCs resulted or retained to tumor cell lines reduced normal microsomes. NLC itself increased microsomal malondialdehyde (MDA) formation. Conclusions: presented. nanocarriers show favorable physicochemical biopharmaceutical properties. cellular experiments anticancer safety. These findings highlight potential applicability gastrointestinal neoplasms build foundation future practical translation.

Language: Английский

Citations

0
Application of liposomal nanoparticles of berberine in photodynamic therapy of A549 lung cancer spheroids DOI Creative Commons
Kave Moloudi, Heidi Abrahamse, Blassan P. George

et al.

Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 40, P. 101877 - 101877

Published: Nov. 17, 2024

Language: Английский

Citations

2